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Celery seed extract and application thereof in anti-hyperuricemia and anti-gout products

A technology of celery seed extract and celery seed, applied in the field of celery seed extract and its application in anti-hyperuricemia and anti-gout products, can solve the problems that need to be further improved

Active Publication Date: 2021-09-14
北京劲得健康科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But, the pharmaceutical composition of this patent application, the effect of treating gout remains to be improved further

Method used

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  • Celery seed extract and application thereof in anti-hyperuricemia and anti-gout products
  • Celery seed extract and application thereof in anti-hyperuricemia and anti-gout products
  • Celery seed extract and application thereof in anti-hyperuricemia and anti-gout products

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0048] A composition, in parts by weight, comprises the following components: 5 parts of celery seed extract, 1 part of Sophora pagoda japonica extract and 1 part of Acerola cherry extract.

[0049] The extraction method of described celery seed extract, comprises the steps:

[0050] (1) adding 3 times of water to celery seed and adjusting the pH to be 5.8, adding 1% enzyme (the enzyme is a mixed enzyme of neutral protease and glucosidase, the mass ratio of the two is 1:1) in Enzymolysis at 50°C for 1 hour, centrifugation to remove volatile oil components, and filtration to obtain filter residue 1 and filtrate 1;

[0051] (2) Add 3 times the amount of ethyl acetate to the filter residue 1 to carry out reflux extraction twice, each reflux time is 1h, and filter to obtain the filter residue 2;

[0052] (3) Add 3 times the amount of 60% ethanol, 75% ethanol and 90% ethanol to the filter residue 2 in order to extract, the extraction temperature is 40°C, and the extraction time of...

Embodiment 2

[0055] A composition comprises the following components in parts by weight: 10 parts of celery seed extract, 5 parts of Sophora pagoda japonica extract and 3 parts of Acerola cherry extract.

[0056] The extraction method of described celery seed extract, comprises the steps:

[0057] (1) adding celery seed to 6 times of water and adjusting the pH to be 7.4, adding 2% enzyme (the enzyme is a mixed enzyme of neutral protease and glucosidase, the mass ratio of the two is 3:1) in Enzymolysis at 60°C for 2 hours, centrifugation to remove volatile oil components, and filtration to obtain filter residue 1 and filtrate 1;

[0058] (2) Add 6 times the amount of ethyl acetate to the filter residue 1 to carry out reflux extraction for 3 times, each reflux time is 2h, and filter to obtain the filter residue 2;

[0059] (3) Add 6 times of 70% ethanol, 85% ethanol and 95% ethanol to the filter residue 2 in sequence for extraction, the extraction temperature is 50°C, the extraction time of...

Embodiment 3

[0062] A composition comprises the following components in parts by weight: 8 parts of celery seed extract, 3 parts of Sophora pagoda japonica extract and 2 parts of Acerola cherry extract.

[0063] The extraction method of described celery seed extract, comprises the steps:

[0064] (1) adding 5 times of water to celery seed and adjusting the pH to be 6, adding 2% enzyme (the enzyme is a mixed enzyme of neutral protease and glucosidase, the mass ratio of the two is 2:1) in Enzymolysis at 55°C for 1.5h, centrifugation to remove volatile oil components, filtration to obtain filter residue 1 and filtrate 1;

[0065] (2) Add 4 times the amount of ethyl acetate to the filter residue 1 to carry out reflux extraction twice, each reflux time is 1.5h, and filter to obtain the filter residue 2;

[0066] (3) Add 4 times the amount of 65% ethanol, 80% ethanol and 95% ethanol to the filter residue 2 in order to extract, the extraction temperature is 45°C, and the extraction time of each ...

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Abstract

The invention relates to the technical field of medicines or foods, in particular to a celery seed extract and application thereof in anti-hyperuricemia and anti-gout products. The extraction method of the celery seed extract comprises the following steps of (1) adding water and enzyme into celery seeds for enzymolysis, centrifuging, removing volatile oil components, and filtering to obtain filter residues 1 and filtrate 1; (2) adding ethyl acetate into the filter residues 1 for reflux extraction, and filtering to obtain filter residues 2; (3) adding the filter residues 2 into a solvent A for extraction, and filtering to obtain filtrate 3; and (4) mixing the filtrate 1 and the filtrate 3, concentrating, adsorbing through macroporous resin, eluting by adopting a solvent B, collecting an eluent, concentrating and drying to obtain the celery seed extract. The celery seed extract has the advantages of being remarkable in hyperuricemia and gout treatment effect and free of toxic and side effects.

Description

technical field [0001] The invention relates to the technical field of medicine or food, in particular to a celery seed extract and its application in anti-hyperuricemia and anti-gout products. Background technique [0002] Gout is a common and complex type of arthritis. Patients often experience sudden joint pain at night. The onset is acute, and severe pain, edema, redness, and inflammation appear in the joints. The pain gradually decreases until it disappears, lasting for several days. days or weeks. [0003] Gout is directly related to hyperuricemia caused by purine metabolism disorder and (or) decreased uric acid excretion, and belongs to the category of metabolic rheumatism. Gout can be complicated by kidney disease. In severe cases, joint damage and renal function damage can occur. It is often accompanied by hyperlipidemia, hypertension, diabetes, arteriosclerosis and coronary heart disease. Hyperuricemia is the basis of gout. [0004] In the records of traditional...

Claims

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Application Information

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IPC IPC(8): A61K36/23A61P19/06A23L33/105A61K131/00
CPCA61K36/23A61P19/06A23L33/105A61K2236/19A61K2236/35A61K2236/333A61K2236/51A23V2002/00A23V2200/30
Inventor 卢承前冯正朋陶黎
Owner 北京劲得健康科技有限公司
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