Celery seed extract and its application in anti-hyperuricemia and anti-gout products

A technology of celery seed extract and Sophora japonica extract, which is applied in the field of medicine, can solve the problems that need to be further improved, and achieve significant synergistic effects, improved anti-hyperuricemia and anti-gout effects, and no toxic side effects

Active Publication Date: 2022-06-24
北京劲得健康科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But, the pharmaceutical composition of this patent application, the effect of treating gout remains to be improved further

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0048] A composition, calculated in parts by weight, comprises the following components: 5 parts of celery seed extract, 1 part of Sophora japonica extract and 1 part of acerola cherry extract.

[0049] The extraction method of described celery seed extract, comprises the steps:

[0050] (1) Add 3 times the amount of water to celery seeds and adjust the pH to 5.8, add 1% of the enzyme (the enzyme is a mixed enzyme of neutral protease and glucosidase, and the mass ratio of the two is 1:1). Enzymatic hydrolysis at 50°C for 1 h, centrifugation to remove volatile oil components, and filtration to obtain filter residue 1 and filtrate 1;

[0051] (2) Add 3 times the amount of ethyl acetate to filter residue 1 to perform reflux extraction for 2 times, each reflux time is 1h, and filter to obtain filter residue 2;

[0052] (3) Add 3 times the amount of 60% ethanol, 75% ethanol and 90% ethanol to the filter residue 2 in turn for extraction, the extraction temperature is 40°C, and the ...

Embodiment 2

[0055] A composition, calculated in parts by weight, comprises the following components: 10 parts of celery seed extract, 5 parts of Sophora japonica extract and 3 parts of Acerola cherry extract.

[0056] The extraction method of described celery seed extract, comprises the steps:

[0057] (1) Add 6 times the amount of water to celery seeds and adjust the pH to 7.4, add 2% of the enzyme (the enzyme is a mixed enzyme of neutral protease and glucosidase, and the mass ratio of the two is 3:1). Enzymatic hydrolysis at 60°C for 2h, centrifugation to remove volatile oil components, and filtration to obtain filter residue 1 and filtrate 1;

[0058] (2) Add 6 times the amount of ethyl acetate to filter residue 1 to perform reflux extraction for 3 times, each reflux time is 2h, and filter to obtain filter residue 2;

[0059] (3) Add 6 times the amount of 70% ethanol, 85% ethanol and 95% ethanol to the filter residue 2 in turn for extraction, the extraction temperature is 50°C, and th...

Embodiment 3

[0062] A composition, calculated in parts by weight, comprises the following components: 8 parts of celery seed extract, 3 parts of Sophora japonica extract and 2 parts of Acerola cherry extract.

[0063] The extraction method of described celery seed extract, comprises the steps:

[0064] (1) Add 5 times the amount of water to celery seeds, adjust the pH to 6, and add 2% of the enzyme (the enzyme is a mixed enzyme of neutral protease and glucosidase, and the mass ratio of the two is 2:1). Enzymatic hydrolysis at 55°C for 1.5h, centrifugation to remove volatile oil components, and filtration to obtain filter residue 1 and filtrate 1;

[0065] (2) Add 4 times the amount of ethyl acetate to filter residue 1 to perform reflux extraction for 2 times, each reflux time is 1.5h, and filter to obtain filter residue 2;

[0066] (3) Add 4 times the amount of 65% ethanol, 80% ethanol and 95% ethanol to the filter residue 2 in turn for extraction, the extraction temperature is 45°C, and ...

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PUM

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Abstract

The invention relates to the technical field of medicines, in particular to a celery seed extract and its application in anti-hyperuricemia and anti-gout products. The extraction method of the celery seed extract comprises the following steps: (1) adding water and enzymes to the celery seed for enzymolysis, centrifuging to remove volatile oil components, and filtering to obtain filter residue 1 and filtrate 1; (2) filter residue 1 Add ethyl acetate for reflux extraction, filter to obtain filter residue 2; (3) add solvent A to filter residue 2 for extraction, filter to obtain filtrate 3; (4) mix filtrate 1 and 3, concentrate, and pass through macroporous resin Adsorbed, eluted with solvent B, collected the eluent, concentrated and dried to obtain the product. The invention has the advantages of remarkable effect in treating hyperuricemia and gout and no toxic and side effects.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a celery seed extract and its application in anti-hyperuricemia and anti-gout products. Background technique [0002] Gout is a common and complex type of arthritis. Patients often experience sudden joint pain at night. The onset is acute, with severe pain, edema, redness, and inflammation in the joints. The pain gradually decreases until it disappears, lasting several days. days or weeks. [0003] Gout is directly related to hyperuricemia caused by disturbance of purine metabolism and / or decreased uric acid excretion, and belongs to the category of metabolic rheumatism. Gout can be complicated by kidney disease. In severe cases, joint destruction and renal function damage may occur, and it is often accompanied by hyperlipidemia, hypertension, diabetes, arteriosclerosis and coronary heart disease. Hyperuricemia is the basis of gout. [0004] In the records of traditional Chin...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/23A61P19/06A23L33/105A61K131/00
CPCA61K36/23A61P19/06A23L33/105A61K2236/19A61K2236/35A61K2236/333A61K2236/51A23V2002/00A23V2200/30
Inventor 卢承前冯正朋陶黎
Owner 北京劲得健康科技有限公司
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