Bacterial cellulose-polyurethane composite material as well as preparation method and application thereof

A technology of bacterial cellulose and composite materials, applied in the field of skin repair, can solve the problems such as the lack of waterproof and antibacterial properties of the three-dimensional nano network structure, the restriction of the application of bacterial cellulose hydrogel dressings, the high water vapor transmission rate, etc. Hydrophilic properties and water absorption capacity, good biocompatibility, and the effect of improving mechanical properties

Active Publication Date: 2021-11-05
钟春燕 +3
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the three-dimensional nano-network structure of bacterial cellulose hydrogel itself lacks good waterproof and anti-bacterial properties, and external microorganisms and water can penetrate into the wound through its nano-network.
At the same time, the bacterial cellulose hydrogel dressing has a large water vapor transmission rate, and the moisture inside it is easy to lose during use.
These problems have restricted the application of bacterial cellulose hydrogel dressings

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0059] This implementation provides a kind of preparation method of bacterial cellulose-polyurethane composite material, it may further comprise the steps:

[0060] Step 1: Soak the bacterial cellulose obtained by fermentation of Acetobacter xylinum in 4% NaOH aqueous solution, heat at 100°C for 6 hours, and then rinse repeatedly with distilled water until neutral; then use high-speed dispersion machine, at a speed of 25,000 rpm, homogenize the purified bacterial cellulose sample for 10 minutes to obtain bacterial cellulose microfibrils with a length of 0.1 μm and a diameter of 50 nm.

[0061] Step 2, soak the homogenized bacterial cellulose microfibers in absolute ethanol for 8 hours to ensure that the bacterial cellulose microfibers are completely dehydrated, and then soak the dehydrated bacterial cellulose microfibers in an organic solvent ethyl ethyl alcohol In glycol acetate for 48h, the preparation obtains composite A, and described composite A is 100wt% by weight, compr...

Embodiment 2

[0069] This implementation provides a kind of preparation method of bacterial cellulose-polyurethane composite material, it may further comprise the steps:

[0070] Step 1: Soak bacterial cellulose obtained by fermenting and culturing Rhizobium and Sarcina in 5% NaOH aqueous solution, heat at 90°C for 5 hours, and then rinse repeatedly with distilled water until neutral and then using a high-speed disperser at a speed of 20,000 rpm to homogenize the purified bacterial cellulose sample for 5 minutes to obtain bacterial cellulose microfibrils with a length of 2 μm and a diameter of 60 nm.

[0071] Step 2, soak the homogenized bacterial cellulose microfibers in absolute ethanol for 10 h to ensure that the bacterial cellulose microfibers are completely dehydrated, and then soak the dehydrated bacterial cellulose microfibers in an organic solvent ethyl acetate 36 h in the ester, the preparation obtains composite A, and described composite A is 100wt% by weight, comprises the bacter...

Embodiment 3

[0079] This implementation provides a kind of preparation method of bacterial cellulose-polyurethane composite material, it may further comprise the steps:

[0080] Step 1: Soak bacterial cellulose obtained by fermenting and culturing Pseudomonas and Achromobacter in 6% NaOH aqueous solution, heat at 80°C for 4 hours, and then rinse repeatedly with distilled water until Neutral; then use a high-speed disperser at a speed of 25,000 rpm to homogenize the purified bacterial cellulose sample for 6 minutes to obtain bacterial cellulose microfibrils with a length of 4 μm and a diameter of 70 nm.

[0081] Step 2, soak the homogenized bacterial cellulose microfibers in absolute ethanol for 9 hours to ensure that the bacterial cellulose microfibers are completely dehydrated, and then soak the dehydrated bacterial cellulose microfibers in the organic solvent butyrolactone In 72h, the compound A was prepared, and the compound A was 100wt% in parts by weight, including 50wt% bacterial cel...

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Abstract

The invention provides a bacterial cellulose-polyurethane composite material as well as a preparation method and application thereof. The preparation method comprises the following steps: carrying out organic solvent exchange treatment on bacterial cellulose microfibers to obtain a compound A and a compound B of the bacterial cellulose microfibers with different concentrations; adding a polymer polyol and a diisocyanate compound under an oil bath condition to carry out an addition polymerization reaction, and carrying out a reaction to obtain a bacterial cellulose composite polyurethane foam prepolymer; and then conducting curing to obtain the bacterial cellulose-polyurethane composite material. The bacterial cellulose microfibers are compounded with the polyurethane foam material, so that the mechanical property of the composite material is remarkably improved; a large number of hydroxyl groups on the surface of the bacterial cellulose nanofiber effectively enhance the hydrophilic performance and the water absorption capacity of the composite material; and meanwhile, the good tissue affinity of the bacterial cellulose can improve the biocompatibility of the polyurethane material.

Description

technical field [0001] The invention belongs to the technical field of skin restoration, and relates to a bacterial cellulose-polyurethane composite material with a gradient structure and a preparation method and application thereof. Background technique [0002] The wound healing process is a continuous dynamic process, which is a process of interaction between cells and cells, cells and cell matrix, and soluble media. Clinically, the healing of wounds is mainly based on the use of wound dressings. With the popularization of the theory and practice of "wet therapy", high-performance wet dressings with moisture absorption function have been paid more and more attention in the world's medical and health fields. [0003] At present, the commonly used dressings in clinic can be divided into bacterial cellulose dressings and polyurethane dressings according to different materials. [0004] Bacterial cellulose is a polymer compound composed of glucose linked by β-1,4-glycosidic ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08G18/76C08G18/75C08G18/64C08G18/66C08G18/48C08G18/32A61L27/40A61L27/56A61L27/20A61L27/18A61K9/70A61K47/34A61K47/36C08G101/00
CPCC08G18/7614C08G18/7671C08G18/755C08G18/724C08G18/6484C08G18/6674C08G18/4833C08G18/4081C08G18/3206A61L27/56A61L27/20A61L27/18A61K9/70A61K47/34A61K47/36C08L1/02C08L75/04
Inventor 钟宇光钟春燕
Owner 钟春燕
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