Porous zinc alloy bone tissue engineering scaffold coated with bioactive coating and preparation method thereof

A technology of bone tissue engineering and bioactivity, applied in coatings, tissue regeneration, prostheses, etc., can solve the problems of poor bioactivity, insufficient mechanical properties of high-porosity porous zinc alloy scaffolds, etc., and achieve excellent biocompatibility , Accelerate healing, good pore connectivity

Active Publication Date: 2021-11-12
TIANJIN UNIVERSITY OF TECHNOLOGY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The purpose of the present invention is to solve the dual problems of insufficient mechanical properties and poor biological activity of high-porosity porous zinc alloy stents, and provide a method of combining percolation casting porous zinc alloy with surface physical adhesion bioactive coating to prepare A bone tissue engineering scaffold with excellent mechanical properties and bioactivity, used for repairing bone tissue defects

Method used

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  • Porous zinc alloy bone tissue engineering scaffold coated with bioactive coating and preparation method thereof
  • Porous zinc alloy bone tissue engineering scaffold coated with bioactive coating and preparation method thereof
  • Porous zinc alloy bone tissue engineering scaffold coated with bioactive coating and preparation method thereof

Examples

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Embodiment 1

[0030] This embodiment relates to a preparation method of a porous zinc alloy bone tissue engineering scaffold coated with a bioactive coating (pectin coating), the pore size is 100 μm-300 μm, the porosity is 50%-70%, and a zinc-lithium alloy is used (Zn-0.8wt.% Li) as the matrix. image 3 The pore distribution and pore size of the porous zinc alloy are shown, and the porosity of the porous zinc alloy is measured by the drainage method. Specific method: put the cut porous sample (φ6×20mm) into a 25ml measuring cylinder filled with 10ml of water, connect the measuring cylinder to a vacuum machine, and vacuumize for about 5 minutes until all the gas in the porous metal is discharged. At this point, record the volume of water displaced by the porous scaffold (V 2 ). The volume of the porous sample is the volume (V 1 =565.2mm 3 ).

[0031] From this formula the porosity of porous samples can be obtained.

[0032] Specific implementation steps:

[0033] Screening of the pa...

Embodiment 2

[0044] This embodiment relates to a preparation method of a porous zinc alloy bone tissue engineering scaffold coated with a bioactive coating (chitosan coating), the pore size is 500 μm-800 μm, the porosity is 70%-90%, and zinc lithium is used Silver alloy (Zn-0.8wt.%Li-0.5wt.%Ag) was used as the matrix. The porosity of the porous zinc alloy was measured by the drainage method, and the steps were the same as in Example 1.

[0045] Specific implementation steps:

[0046] Screening of the particle size of sodium chloride particles: Pass the sodium chloride particles through 20-mesh and 32-mesh sieves respectively to obtain sodium chloride particles with a particle size ranging from 500 μm to 800 μm. After the screening is completed, dry at 500°C for 2 hours.

[0047] Put 300g of sodium chloride pellets into a mold whose size is Carry out preheating, preheat to 400 ℃ and keep warm. And during this process, the sodium chloride particles are continuously compacted to make the...

Embodiment 3

[0057] This example relates to a preparation method of a porous zinc alloy bone tissue engineering scaffold coated with a bioactive coating (sodium alginate coating), the pore size is 500 μm-800 μm, the porosity is 70%-90%, and zinc lithium is used Manganese alloy (Zn-0.8wt.%Li-0.5wt.%Mn) as the matrix. The porosity of the porous zinc alloy was measured by the drainage method, and the steps were the same as in Example 1.

[0058] Specific implementation steps:

[0059] Screening of the particle size of sodium chloride particles: Pass the sodium chloride particles through 20-mesh and 32-mesh sieves respectively to obtain sodium chloride particles with a particle size ranging from 500 μm to 800 μm. After the screening is completed, dry at 400°C for 6 hours.

[0060] Put 300g of sodium chloride pellets into a mold whose size is Carry out preheating, preheat to 400 ℃ and keep warm. And during this process, the sodium chloride particles are continuously compacted to make the s...

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Abstract

The invention discloses a porous zinc alloy bone tissue engineering scaffold coated with a bioactive coating and a preparation method thereof, and solves the problems of low mechanical strength and poor biological activity of an existing high-porosity zinc alloy bone tissue engineering scaffold. The porous zinc alloy bone tissue engineering scaffold is prepared by alloy smelting, air pressure infiltration casting and coating. The preparation method comprises the steps: 1, screening out sodium chloride particles with different particle sizes, pouring the sodium chloride particles into a mold, compacting and preheating; 2, adding one to three types of Li, Ag and Mn into the molten zinc liquid; 3, pouring the zinc alloy liquid into the mold filled with the sodium chloride particles, and carrying out air pressure infiltration; 4, after cooling, washing off the sodium chloride particles to remain the porous zinc alloy; 5, carrying out wire cutting on the porous zinc alloy, and then carrying out acid treatment; and 6, immersing the treated porous zinc alloy in a polymer (sodium alginate, pectin, chitosan and the like) solution, and carrying out centrifugal drying. The porous zinc alloy bone tissue engineering scaffold with a high porosity, an adjustable aperture, high strength and a good biological activity is obtained.

Description

technical field [0001] The invention relates to a preparation method of a degradable porous zinc alloy bone tissue engineering scaffold, which mainly includes the preparation of porous zinc alloy (Zn, Li, Ag, Mn) and the preparation of a bioactive coating on the surface of the porous zinc alloy, belonging to the bone tissue engineering scaffold The technical field of design, preparation and application of biomedical materials. Background technique [0002] Bone tissue engineering scaffolds are mainly used for the repair of bone defects caused by bone tumors, osteoinflammation or trauma. Current research is mainly focused on polymers (PLGA), bioactive glass or ceramics, non-degradable metals (titanium alloys), and biodegradable Degrades metals in several directions. Bone tissue engineering scaffolds prepared from various materials have their own advantages and disadvantages. Polymers have low mechanical strength, and bioactive glass and ceramics have good bioactivity, but a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/56A61L27/50A61L27/04A61L27/34A61L27/54
CPCA61L27/56A61L27/50A61L27/047A61L27/34A61L27/54A61L2430/02A61L2300/606A61L2300/412A61L2300/232C08L5/06C08L5/04C08L5/08
Inventor 陈民芳孙逢栋由臣
Owner TIANJIN UNIVERSITY OF TECHNOLOGY
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