The invention provides a laboratory high-temperature and high-pressure mud cake cementation quality evaluation device, which mainly includes a high-temperature autoclave (19), a simulated shaft (13), an intermediate container (22), a heating and cooling system, a pressure source and a pressure system, and a data set. Acquisition controller (23), computer (30) and output device (31). Its function is to simulate downhole pressure and temperature conditions, realize continuous experimental operations such as drilling fluid wellbore fluid loss, drilling fluid flushing and displacement, cementing fluid injection, and solidification of cementing fluid, and simulate and evaluate downhole drilling fluid and mud cake. The impact on the cementing quality of the cementing fluid interface, the evaluation of the flushing effect of different flushing fluids on the annulus, the shear cementation strength of the interface between the two is measured by pressure shear, and the hydraulic cementation strength of the interface between the two is measured by the principle of water pressure channeling. Provide experimental data for performance formulation optimization and engineering design of drilling fluid and cementing fluid in oilfield drilling engineering.