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Preparation method of intelligent responsive biomass-based material and application of intelligent responsive biomass-based material in controlled release of drugs

A biomass and responsive technology, which can be used in non-active ingredient medical preparations, medical preparations containing active ingredients, and pharmaceutical formulations, etc., can solve the problems of low drug load, poor release performance, and complex preparation. Achieve the effect of increasing the amount of sustained release, good chemical stability and low price

Active Publication Date: 2021-11-30
GUANGXI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, most of the intelligent responsive drug controlled release materials used, such as chitosan, MOFs, liposomes, etc., are expensive, complicated to prepare, low in drug loading and poor in release performance.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Example 1: Preparation of Smart Responsive Biomass-Based Materials

[0028] (1) First, the TEMPO / NaBr / NaClO oxidation system and cellulose are based on the mass ratio of TEMPO to cellulose of 1:2, the mass ratio of NaBr to cellulose to 1:3, and the mass ratio of NaClO to cellulose to be 1:2: 5 was placed in an aqueous solution, oxidized for 0.5 hours, and the reaction temperature was 30° C. After suction filtration, the carboxylated nanocellulose was obtained.

[0029] (2) The temperature-responsive monomer N-isopropylacrylamide and the pH-responsive polymer hyperbranched polyethyleneimine are placed in an aqueous solution at a molar ratio of 1:2 and reacted under magnetic stirring at 60° C. for 24 hours to obtain Temperature, pH-responsive hyperbranched polyethyleneimine.

[0030] (3) in step (2), the hyperbranched polyethyleneimine and the photoresponsive monomer azobenzene-4-carboxylic acid of the obtained temperature and pH response are placed in an aqueous solutio...

Embodiment 2

[0034] Example 2: Preparation of Smart Responsive Biomass-Based Materials

[0035] (1) mix succinic anhydride, N-bromosuccinimide and dry dry hemicellulose according to mass ratio of 30:1:10, react for 6 hours, and the reaction temperature is 70 ° C, and suction filtration obtains the carboxyl group Hemicellulose substrate.

[0036] (2) The temperature-responsive monomer N-isopropylacrylamide and the pH-responsive polymer hyperbranched polyamine are placed in an aqueous solution at a molar ratio of 1:2 and reacted under magnetic stirring at 60° C. for 24 hours to obtain a temperature, pH-responsive hyperbranched polyamines.

[0037] (3) The temperature- and pH-responsive hyperbranched polyamines obtained in the step (2) and the photoresponsive monomer azobenzene-3,3'-dicarboxylic acid are placed in an aqueous solution in a molar ratio of 1:24 and reacted at room temperature for 24 hours, temperature, pH and light responsive hyperbranched polyamines were prepared.

[0038] (...

Embodiment 3

[0041] Example 3: Preparation of Smart Responsive Biomass-Based Materials

[0042] (1) adding the lignin aqueous solution whose mass fraction is 50wt% to cobalt acetylacetonate and cerium borate (the mass ratio of cobalt acetylacetonate and cerium borate is 1:10), reacted for 30min, and the reaction temperature was 100 ° C, and suction filtration obtained Carboxylated lignin.

[0043] (2) The temperature-responsive monomer dimethylaminoethyl acrylate and the pH-responsive polymer hyperbranched polyethyleneimine were placed in an aqueous solution at a molar ratio of 1:2 and reacted under magnetic stirring at 60° C. for 24 hours to obtain a temperature , pH-responsive hyperbranched polyethyleneimine.

[0044] (3) in step (2), the hyperbranched polyethyleneimine and the photoresponsive monomer azobenzene-4-carboxylic acid of the obtained temperature and pH response are placed in an aqueous solution according to a molar ratio of 1:24 and reacted at room temperature for 24 hours t...

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PUM

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Abstract

The invention discloses preparation of an intelligent biomass-based material responding to temperature, pH and light and application of the intelligent biomass-based material in controlled release. Biomass is used as a matrix, firstly, the biomass matrix is oxidized, hydroxyl on the biomass matrix is oxidized into carboxyl, and a carboxylated biomass matrix is prepared; and then a temperature-sensitive responsive monomer and a light-responsive monomer are grated to a pH-responsive polymer hyperbranched amine through a Michael addition reaction and an amidation reaction respectively, and then the modified hyperbranched amine is grated to a carboxylated biomass matrix through the amidation reaction to prepare the intelligent responsive biomass-based material. The material obtained through the method has the advantages of being good in stability, high in biocompatibility and easy to prepare, can load various hydrophilic and hydrophobic drugs and other substances, is high in loading capacity, can achieve intelligent responsiveness in the controlled release process so as to control the slow release amount and the release time, and has good application prospects.

Description

technical field [0001] The invention relates to the technical field of drug controlled release, in particular to a preparation method of an intelligent biomass-based material with triple response of temperature, pH and light and its application in drug controlled release. Background technique [0002] Whether in the human body or in agriculture and animal husbandry, the controlled release of drugs has always been a problem worthy of research in biology. In view of the importance of drug controlled release, it is very important to develop a simple preparation of drug sustained release substrate. In recent years, researchers in various countries have developed a variety of drug controlled release materials, but there are some problems. At present, most of the intelligent responsive drug controlled release materials used, such as chitosan, MOFs, liposomes, etc., are expensive, complicated to prepare, low drug load and poor release performance. SUMMARY OF THE INVENTION [00...

Claims

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Application Information

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IPC IPC(8): C08G81/02C08B15/04C08B37/14C08H7/00C08F8/30C08F283/00C08F220/54C08F220/34A61K31/12A61K31/407A61K31/4745A61K31/704A61K47/30A61K47/38
CPCC08G81/02C08B15/04C08B37/006C08H6/00C08F8/30A61K47/38A61K47/30A61K31/704A61K31/4745A61K31/407A61K31/12C08F283/00C08F220/54C08F220/34
Inventor 朱红祥陈智平梁渝廷何辉王磊熊建华
Owner GUANGXI UNIV
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