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Compound tacrolimus cream as well as preparation method and application thereof

A technology of tacrolimus and composition, applied in the field of compound tacrolimus cream and its preparation, can solve the problems of skin atrophy, pigmented spots and the like, and achieve the effects of low dosage, high safety and improving therapeutic effect

Pending Publication Date: 2021-12-03
深圳大学附属华南医院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Glucocorticoids have the functions of suppressing immune response, anti-allergy, and anti-inflammation. After external use, they can reduce congestion and edema, and quickly relieve clinical symptoms such as itching and skin lesions. Hormone use dependence, especially after long-term and large-scale use of strong hormone preparations on the face and genitals, it is easy to cause various adverse reactions such as skin atrophy, thinning, telangiectasia, pigmented spots, hirsutism, and skin aging. , has brought certain limitations to these antifungal or antibacterial and anti-inflammatory compound topical preparations

Method used

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  • Compound tacrolimus cream as well as preparation method and application thereof
  • Compound tacrolimus cream as well as preparation method and application thereof
  • Compound tacrolimus cream as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0054] A compound tacrolimus cream prepared from the following components: metronidazole, ketoconazole, tacrolimus, laurocapram, stearyl alcohol, stearic acid, liquid paraffin, triethanolamine, glycerin , Ethyl Paraben, Allantoin, Water, Camphor and Borneol.

[0055] Its preparation method is:

[0056] (1) Take stearyl alcohol, stearic acid, laurocaprazine, and liquid paraffin and heat to dissolve. When the temperature rises to 80°C, add ketoconazole and tacrolimus and stir until completely dissolved to obtain an oil phase mixture.

[0057] (2) Take glycerin, add water and mix evenly, then add triethanolamine, ethylparaben and allantoin, heat to 80°C, then add metronidazole, stir until completely dissolved, and obtain an aqueous phase mixture.

[0058] (3) Slowly add the aqueous phase mixture prepared in step (2) to the oil phase mixture prepared in step (1), stir while adding, and then use a homogeneous emulsifier (the homogeneous condition is 4000rpm , homogenized for 15 m...

Embodiment 2

[0061] A compound tacrolimus cream prepared from the following components: metronidazole, ketoconazole, tacrolimus, laurocapram, stearyl alcohol, stearic acid, liquid paraffin, triethanolamine, glycerin , Ethyl Paraben, Allantoin, Water, Camphor and Borneol.

[0062] Its preparation method is:

[0063] (1) Take stearyl alcohol, stearic acid, laurocaprazine, and liquid paraffin and heat to dissolve. When the temperature rises to 80°C, add ketoconazole and tacrolimus and stir until completely dissolved to obtain an oil phase mixture.

[0064] (2) Take glycerin, add water and mix evenly, then add triethanolamine, ethylparaben and allantoin, heat to 80°C, then add metronidazole, stir until completely dissolved, and obtain an aqueous phase mixture.

[0065] (3) Slowly add the aqueous phase mixture prepared in step (2) to the oil phase mixture prepared in step (1), stir while adding, and then use a homogeneous emulsifier (the homogeneous condition is 4000rpm , homogenized for 15 m...

Embodiment 3

[0068] A compound tacrolimus cream prepared from the following components: metronidazole, ketoconazole, tacrolimus, laurocapram, stearyl alcohol, stearic acid, liquid paraffin, triethanolamine, glycerin , Ethyl Paraben, Water, Allantoin, Camphor and Borneol.

[0069] Its preparation method is:

[0070] (1) Take stearyl alcohol, stearic acid, laurocaprazine, and liquid paraffin and heat to dissolve. When the temperature rises to 80°C, add ketoconazole and tacrolimus and stir until completely dissolved to obtain an oil phase mixture.

[0071] (2) Take glycerin, add water and mix evenly, then add triethanolamine, ethylparaben and allantoin, heat to 80°C, then add metronidazole, stir until completely dissolved, and obtain an aqueous phase mixture.

[0072] (3) Slowly add the aqueous phase mixture prepared in step (2) to the oil phase mixture prepared in step (1), stir while adding, and then use a homogeneous emulsifier (the homogeneous condition is 4000rpm , homogenized for 15 m...

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Abstract

The invention discloses a compound tacrolimus cream and a preparation method and application thereof, the compound tacrolimus cream contains metronidazole, ketoconazole and tacrolimus, and the content of the tacrolimus is 0.03-0.1% (mass percent). The metronidazole, the ketoconazole and the tacrolimus have an excellent synergistic effect, can play a better role in inhibiting dermatophyte, saccharomycetes and some deep fungi, improve the treatment effect on anaerobic bacteria infection, have a targeted and radical treatment effect on inflammation caused by repeated attack of tinea cruris, tinea manuum, tinea pedis and the like, and the dosage is lower due to combination of the three components. The compound tacrolimus cream does not contain hormone components, so that the safety is higher, and the patient acceptability is better.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to a compound tacrolimus cream and its preparation method and application. Background technique [0002] In related technologies, commonly used antifungal or antibacterial and anti-inflammatory compound external preparations, such as Pikang Cream, Pikangwang, Compound Kangnale Cream, Compound Diacryl Cream, Triamcinolone Acetonide Econazole Cream, and Compound Clobetasol Milk Ointment, econazole, triamcinolone acetonide, etc., can be used for dermatitis, eczema, tinea manuum, tinea corporis, jock itch, tinea versicolor and diaper dermatitis and other common skin diseases, but these compound external preparations are more or less Less contain glucocorticoids. Glucocorticoids have the functions of suppressing immune response, anti-allergy, and anti-inflammation. After external use, they can reduce congestion and edema, and quickly relieve clinical symptoms such as itching and skin...

Claims

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Application Information

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IPC IPC(8): A61K31/496A61K31/436A61K31/4164A61K9/06A61P17/00A61P25/00A61P17/04A61P31/02A61P31/10A61P31/04A61P29/00A61P17/02A61P17/08A61K31/4166A61K31/125A61K31/045
CPCA61K31/496A61K31/436A61K31/4164A61K9/06A61K9/0014A61K47/22A61K31/4166A61K31/125A61K31/045A61P17/00A61P25/00A61P17/04A61P31/02A61P31/10A61P31/04A61P29/00A61P17/02A61P17/08A61K2300/00
Inventor 孙仁山刘楠曾悦
Owner 深圳大学附属华南医院
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