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Medical magnesium alloy barrier membrane for alveolar bone defect repair and preparation method of medical magnesium alloy barrier membrane

A magnesium alloy and barrier film technology, which is applied in medical science, prosthesis, coating, etc., can solve the problems of poor antibacterial effect and fast degradation rate of magnesium alloy barrier film, and achieve the effect of improving the bonding strength

Active Publication Date: 2021-12-03
TIANJIN POLYTECHNIC UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] Aiming at the problems of too fast degradation rate and poor antibacterial effect of the magnesium alloy barrier film, the present invention provides a medical magnesium alloy barrier film for alveolar bone defect repair and a preparation method thereof. The magnesium alloy barrier film is an outer surface Medical magnesium alloy coated with chitosan-calcium phosphorus composite coating, the preparation method includes laser remelting, micro-arc oxidation and vacuum impregnation and pulling

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  • Medical magnesium alloy barrier membrane for alveolar bone defect repair and preparation method of medical magnesium alloy barrier membrane
  • Medical magnesium alloy barrier membrane for alveolar bone defect repair and preparation method of medical magnesium alloy barrier membrane
  • Medical magnesium alloy barrier membrane for alveolar bone defect repair and preparation method of medical magnesium alloy barrier membrane

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preparation example Construction

[0031] A medical magnesium alloy barrier film for alveolar bone defect repair and its preparation method according to the present invention, the specific implementation of this preparation method has the following steps:

[0032] Step 1: Mechanical grinding and chemical polishing to obtain a pre-treated surface

[0033] In order to facilitate the test, use a wire cutting machine to cut medical magnesium alloy plates or rods into 100mm×100mm×1mm square pieces or Φ100mm×1mm discs, pretreat the surface to be coated, and mechanically grind with water sandpaper to remove surface oxidation Skin and impurities, followed by alkali washing with 20g / L concentration of NaOH to remove surface oil, ultrasonic cleaning in acetone and absolute ethanol for 15min, and cold air drying.

[0034] The second step: laser remelting to prepare the pre-treated surface

[0035] Using low power CO 2 The laser prepares a patterned pretreatment surface on the medical magnesium alloy pretreatment surface...

Embodiment 1

[0043] Step 1: Mechanical grinding and chemical polishing to obtain a pre-treated surface

[0044] In order to facilitate the test, the Mg-1Zn-0.1Mn medical magnesium alloy plate was cut into square pieces of 100mm×100mm×1mm by a wire cutting machine, and the surface to be coated was pretreated by using 1000#, 1500#, 2000#, 3000# Water sandpaper is mechanically ground to remove surface scale and impurities, followed by alkaline washing with 20g / L NaOH to remove surface oil, ultrasonic cleaning in acetone and absolute ethanol for 15 minutes, and cold air drying.

[0045] The second step: laser remelting to prepare the pre-treatment surface

[0046] Using low power CO 2 The laser prepares a patterned pretreatment surface on the Mg-1Zn-0.1Mn medical magnesium alloy pretreatment surface obtained in the first step. The laser power is 15W, the scanning rate is 300mm / s, and the single-pass scanning distance is 0.01mm. The scanning path as a series of concentric circles.

[0047] T...

Embodiment 2

[0061] Step 1: Mechanical grinding and chemical polishing to obtain a pre-treated surface

[0062] In order to facilitate the test, the Mg-2Zn-0.4Mn medical magnesium alloy rods were cut into Φ100mm×1mm discs with a wire cutting machine, and the surface to be coated was pretreated with 1000#, 1500#, 2000#, 3000# water Sandpaper is mechanically ground to remove surface scale and impurities, followed by alkali washing with 20g / L NaOH to remove surface oil, ultrasonic cleaning in acetone and absolute ethanol for 15 minutes, and cold air drying.

[0063] The second step: laser remelting to prepare the pre-treatment surface

[0064] Using low power CO 2 The laser prepares a patterned pretreatment surface on the Mg-2Zn-0.4Mn medical magnesium alloy pretreatment surface obtained in the first step. The laser power is 20W, the scanning rate is 320mm / s, and the single-pass scanning distance is 0.02mm. The scanning path as a series of concentric squares.

[0065] The third step: prepa...

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Abstract

The invention provides a medical magnesium alloy barrier membrane for alveolar bone defect repair and a preparation method of the medical magnesium alloy barrier membrane. The medical magnesium alloy barrier membrane is medical magnesium alloy with the outer surface wrapped with a chitosan-calcium phosphorus composite coating, and the medical magnesium alloy is any one of plates or bars with different components of Mg-xZn-yMn (x is 1-6 wt.%, and y is 0.1-1.0 wt.%); and the porosity of the calcium phosphorus coating is 30-60%, the pore size is 0.1-3.5 [mu] m, and the thickness of the chitosan-calcium phosphorus composite coating is 5.4-20.2 [mu] m. According to the preparation method, laser remelting, micro-arc oxidation and vacuum dipping lifting are comprehensively utilized. The corrosion-resistant antibacterial magnesium alloy barrier membrane prepared by the method is suitable for the field of oral implantation.

Description

technical field [0001] The invention belongs to the technical field of biomedical metal materials, in particular to a medical magnesium alloy barrier film for alveolar bone defect repair and a preparation method thereof. Background technique [0002] Guided bone regeneration is a standard procedure for bone defect repair in dental implantology. The key factor determining its long-term efficacy is the material and performance of the barrier membrane. The barrier membranes currently used clinically can be divided into non-degradable types such as polytetrafluoroethylene membranes and titanium membranes, and degradable types such as collagen membranes and polyester membranes. However, the mechanical properties, degradation behavior, and biological activity of the existing barrier membranes have not yet achieved an ideal fit. Simply put, non-degradable membranes have high mechanical strength and good soft tissue isolation, but they are easy to be exposed to infection and require...

Claims

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Application Information

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IPC IPC(8): A61L27/34A61L27/32A61L27/04A61L27/54A61L27/58C25D11/30
CPCA61L27/34A61L27/32A61L27/047A61L27/54A61L27/58C25D11/026C25D11/30A61L2420/02A61L2420/06A61L2420/08A61L2430/02C08L5/08
Inventor 郑洋张璇
Owner TIANJIN POLYTECHNIC UNIV