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Preparation method of physalis alkekengi extract, physalis alkekengi extract and application of physalis alkekengi extract

An extraction method and extract technology, which are applied in the field of medicine, can solve the problems of low content of active ingredients and incomplete extraction of species, and achieve the effects of high extraction rate, saving of raw materials and reagents, and increase of diffusion coefficient.

Active Publication Date: 2021-12-07
CHINA PHARM UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Purpose of the invention: Aiming at the problems existing in the prior art, such as low content of extracted active ingredients and incomplete extraction of species, the present invention provides a method for preparing brocade lantern extract. The preparation method of the present invention can efficiently extract from fresh brocade lanterns Extract the total steroids such as Physalis A and other total steroids and the total flavonoids such as luteolin to obtain the brocade lantern extract

Method used

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  • Preparation method of physalis alkekengi extract, physalis alkekengi extract and application of physalis alkekengi extract
  • Preparation method of physalis alkekengi extract, physalis alkekengi extract and application of physalis alkekengi extract
  • Preparation method of physalis alkekengi extract, physalis alkekengi extract and application of physalis alkekengi extract

Examples

Experimental program
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Effect test

Embodiment 1

[0043] Using Jindeng as raw material, prepare the total steroid extract of Jindeng according to the following process

[0044] (1) Take brocade lanterns as the raw material, wash and fully dry, then use a powder machine to powder, pass through an 80-mesh sieve, mix well, and use it as the powder to be extracted;

[0045] (2) Put the brocade lantern powder to be extracted into an ethanol solution with a mass fraction of 70% according to a material-to-liquid ratio of 1:20 mg / mL. The ethanol solution contains 5% Tween-80 by volume and a compound enzyme with a mass fraction of 2%. The mass ratio of cellulase and papain in the compound enzyme is 1:1; the pH of the mixed solution is adjusted to 5 with a hydrochloric acid solution with a pH of 1, and the ultrasonic extraction is performed at a power of 150W for 30 minutes;

[0046] (3) the extract of step (2) gained is suction filtered, and the filtrate is lyophilized after concentrating under reduced pressure to obtain total steroid...

Embodiment 2

[0048] Using Jindeng as raw material, prepare the total steroid extract of Jindeng according to the following process

[0049] (1) Take brocade lanterns as the raw material, wash and fully dry, then use a powder machine to powder, pass through an 80-mesh sieve, mix well, and use it as the powder to be extracted;

[0050] (2) Put the brocade lantern powder to be extracted into an ethanol solution with a mass fraction of 90% according to a material-to-liquid ratio of 1:12 mg / mL. The ethanol solution contains 4% Span-80 by volume and a compound enzyme with a mass fraction of 1%. The mass ratio of cellulase and papain in the compound enzyme is 1:2; the pH of the mixed solution is adjusted to 3 with hydrochloric acid solution, and the ultrasonic extraction is performed at a power of 100W for 20 minutes;

[0051] (3) The extract obtained in step (2) was suction-filtered, and the filtrate was concentrated under reduced pressure and freeze-dried to obtain total steroid extracts such a...

Embodiment 3

[0053] Using Jindeng as raw material, prepare the total steroid extract of Jindeng according to the following process

[0054] (1) Take brocade lanterns as the raw material, wash and fully dry, then use a powder machine to powder, pass through an 80-mesh sieve, mix well, and use it as the powder to be extracted;

[0055] (2) Put the brocade lantern powder to be extracted into the ethanol solution with a mass fraction of 50% according to the ratio of material to liquid: 1:40mg / mL, the ethanol solution contains 6% Triton X-100 by volume fraction, and a compound enzyme with a mass fraction of 3%, The mass ratio of cellulase and papain in the complex enzyme is 2:1; the pH of the mixed solution is adjusted to 4 with hydrochloric acid solution, and the ultrasonic extraction is performed at a power of 200W for 40 minutes;

[0056] (3) The extract obtained in step (2) was suction-filtered, and the filtrate was concentrated under reduced pressure and then freeze-dried to obtain total s...

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Abstract

The invention discloses a preparation method of a physalis alkekengi extract, the physalis alkekengi extract and an application of the physalis alkekengi extract. The preparation method comprises the following steps: taking physalis alkekengi as a raw material, and performing crushing and performing mixing to obtain to-be-extracted powder; putting the to-be-extracted powder into an extraction solvent containing a compound enzyme and a surfactant, adjusting the pH value, and performing ultrasonic extraction; filtering an extracting solution, performing concentrating under reduced pressure, and performing freeze-drying to obtain an extract A; drying filter residues, adding the dried filter residues into water containing an antioxidant, adjusting the pH, and performing reflux extraction; filtering the extracting solution, performing concentrating under reduced pressure, and performing freeze-drying to obtain an extract B; and uniformly mixing the extract A with the extract B to obtain the physalis alkekengi extract. The prepared physalis alkekengi extract contains 72.5%-91.6% of physalis alkekengi total steroids, 61.0%-86.7% of physalis alkekengi total flavonoids and rich physalin A and luteolin, and has an obvious anti-inflammatory effect.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a preparation method of a brocade lantern extract and the brocade lantern extract and application thereof. Background technique [0002] Acute pharyngitis (AP) is an acute inflammation involving the pharyngeal mucosa, submucosal tissue, and surrounding lymphoid tissue. It is a self-limiting disease with a mild condition. However, if relevant interventions are not performed continuously, some serious complications may be induced Such as ear and sinus infections, myocarditis, etc. According to the latest survey data, 616 million people worldwide suffer from acute pharyngitis every year. At present, the drugs mainly used for the treatment of inflammation include glucocorticoids and non-steroidal anti-inflammatory drugs. These western medicines have side effects such as water and sodium retention / gastrointestinal tract. As a characteristic traditional Chinese medicine ...

Claims

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Application Information

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IPC IPC(8): A61K36/81A61P11/04A61P1/00A61P31/04
CPCA61K36/81A61P11/04A61P1/00A61P31/04A61K2236/19A61K2236/333
Inventor 李斯文顾月清李珏泉
Owner CHINA PHARM UNIV
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