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Low-pressure in-situ antibacterial repair-promoting electrospinning dressing and preparation method thereof

An electrospinning, in-situ technology, used in electrospinning, textiles and papermaking, medical science, etc., can solve safety problems, secondary wound injuries, etc., achieve strong water absorption, promote collagen proliferation, and spin speed. Toxic and pollution-free effect

Active Publication Date: 2021-12-14
SOUTH CHINA UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But above-mentioned prepared electrospinning dressings all have deficiencies, such as using larger voltage (more than 10KV) to cause safety problem easily; Electrospinning solvent often selects poisonous such as dichloromethane, chloroform, acetone, hexafluoroisopropanol, Solvents with a pungent odor often require dressings to be prepared in designated equipment; the prepared electrospun dressings need to be divided into two steps for wound care. First, a professional electrospun machine is used to prepare a dressing sheet of a specified shape, and then it is used to fix the patient's wound with adhesive tape use, it is easy to cause secondary damage to the wound

Method used

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  • Low-pressure in-situ antibacterial repair-promoting electrospinning dressing and preparation method thereof
  • Low-pressure in-situ antibacterial repair-promoting electrospinning dressing and preparation method thereof
  • Low-pressure in-situ antibacterial repair-promoting electrospinning dressing and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] Step 1: Weigh 5g of PVB and add it to 200ml of hot water at 70°C for washing. After washing, centrifuge and dehydrate to remove the supernatant, repeat washing for 5 times, dry in vacuum at 75°C for 8 hours, grind and sieve to obtain pretreated PVB powder ;

[0038] Step 2: Weigh 0.24g of PVP powder, weigh 0.56g of the PVB powder in step 1 and dissolve them in 5g of absolute ethanol, stir for 2h to obtain a uniformly mixed polymer spinning solution;

[0039] Step 3: Weigh 0.2g of blue copper peptide and dissolve in 0.1g of ultrapure water and stir until completely dissolved, weigh 0.1g of borneol and 50mg of organic polyquaternium-73, dissolve in 3.65g of absolute ethanol and stir until completely dissolved;

[0040] Step 4: Add all the solution in step 3 to the spinning solution prepared in step 2, and keep stirring until the solution is completely mixed to obtain 8 wt% of the polymer solute, 2 wt% of azurite peptide, and 1 wt% of borneol. Quaternary ammonium salt-73...

Embodiment 2

[0046] Step 1: Weigh 5g of PVB and add it to 200ml of hot water at 70°C for washing. After washing, centrifuge to remove the supernatant, repeat washing for 3 times, dry in vacuum at 75°C for 6 hours, grind and sieve to obtain pretreated PVB powder ;

[0047] Step 2: Weigh 0.6g of PVP powder, weigh 0.9g of the PVB powder in step 1 and dissolve them in 5g of absolute ethanol, stir for 2h to obtain a uniformly mixed polymer spinning solution;

[0048] Step 3: Weigh 0.1g of blue copper peptide and dissolve in 0.1g of ultrapure water and stir until completely dissolved, weigh 50mg of borneol and 50mg of organic polyquaternium-73 and dissolve in 3.1g of absolute ethanol and stir until completely dissolve;

[0049] Step 4: Add all the solution in step 3 to the spinning solution prepared in step 2, and continue to stir until the solution is completely mixed to obtain a polymer solute with a mass of 15wt%, a blue copper peptide with 1wt%, and borneol with 0.5wt%. Organic Polyquatern...

Embodiment 3

[0054] Step 1: Weigh 5g of PVB and add it to 200ml of hot water at 75°C for water washing. After washing, centrifuge to remove the supernatant, repeat washing for 5 times, vacuum dry at 75°C for 6 hours, grind and sieve to obtain pretreated PVB powder ;

[0055] Step 2: Weigh 0.3g of PVP powder, weigh 0.7g of the PVB powder in step 1 and dissolve them in 5g of absolute ethanol, stir for 2h to obtain a uniformly mixed polymer spinning solution;

[0056] Step 3: Weigh 60mg of blue copper peptide and dissolve in 0.1g of ultrapure water and stir until completely dissolved, weigh 0.1g of borneol and 50mg of organic polyquaternium-73 and dissolve in 3.49g of absolute ethanol and stir until completely dissolve;

[0057] Step 4: Add all the solution in step 3 to the spinning solution prepared in step 2, and continue to stir until the solution is completely mixed to obtain 10wt% of the polymer solute, 0.6wt% of azurite peptide, and 1wt% of borneol, organic Polyquaternium-73 is 0.5wt%...

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Abstract

The invention discloses a low-pressure in-situ antibacterial repair-promoting electrospinning dressing and a preparation method thereof. The method comprises the following steps: completely dissolving polymers PVP (Polyvinyl Pyrrolidone) and PVB (Polyvinyl Butyral) by using absolute ethyl alcohol, then adding absolute ethyl alcohol or ultrapure water to dissolve a functional medicine solution, adding a prepared spinning precursor solution into a low-voltage portable electrostatic spinning device, and adjusting spinning parameters to ensure that the bacteriostatic repair-promoting dressing is deposited in situ at a wound. The electrostatic spinning fiber membrane prepared by adopting the method has good air permeability and degradability, and the safety is high by adopting low-voltage equipment. The blue copper peptide and the organic polyquaternium-73 have a synergistic antibacterial effect, are not easy to generate drug resistance, and can promote wound repair, and the addition of the humectant enables the wound to better keep a moist environment, and does not cause secondary damage to the skin.

Description

technical field [0001] The invention belongs to the field of biomedical dressings, and in particular relates to a low-pressure in-situ antibacterial and repair-promoting electrospun dressing and a preparation method thereof. Background technique [0002] Acute wounds refer to wounds that form suddenly and can heal within 4-8 weeks, and the pathological development conforms to the classic wound repair process. Once the wound healing process is hindered by certain factors, such as ischemia, infection, dryness, etc., the wound healing process will be delayed or even stagnated, eventually forming a chronic non-healing wound. The occurrence of acute wounds is often accompanied by severe trauma and bleeding, which is likely to be life-threatening, and its timely treatment and care are urgent. [0003] Maintaining a good local wound environment is essential for wound healing. Studies have shown that a moist wound environment can prevent cell dehydration, stimulate cell migration ...

Claims

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Application Information

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IPC IPC(8): A61L15/24A61L15/46A61L15/44D01D5/00A61L15/20A61L15/26A61L15/32
CPCA61L15/225A61L15/46A61L15/44D01D5/003A61L15/20A61L15/26A61L15/32A61L2300/252A61L2300/208A61L2300/216A61L2300/45A61L2300/404A61L2300/412C08L39/06C08L29/14
Inventor 郑华德王妍寇昊迪黄思真
Owner SOUTH CHINA UNIV OF TECH
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