Low-pressure in-situ antibacterial repair-promoting electrospinning dressing and preparation method thereof

An electrospinning, in-situ technology, used in electrospinning, textiles and papermaking, medical science, etc., can solve safety problems, secondary wound injuries, etc., achieve strong water absorption, promote collagen proliferation, and spin speed. Toxic and pollution-free effect
CN113786512AActive Publication Date: 2021-12-14SOUTH CHINA UNIV OF TECH
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
SOUTH CHINA UNIV OF TECH
Publication Date
2021-12-14

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Abstract

The invention discloses a low-pressure in-situ antibacterial repair-promoting electrospinning dressing and a preparation method thereof. The method comprises the following steps: completely dissolving polymers PVP (Polyvinyl Pyrrolidone) and PVB (Polyvinyl Butyral) by using absolute ethyl alcohol, then adding absolute ethyl alcohol or ultrapure water to dissolve a functional medicine solution, adding a prepared spinning precursor solution into a low-voltage portable electrostatic spinning device, and adjusting spinning parameters to ensure that the bacteriostatic repair-promoting dressing is deposited in situ at a wound. The electrostatic spinning fiber membrane prepared by adopting the method has good air permeability and degradability, and the safety is high by adopting low-voltage equipment. The blue copper peptide and the organic polyquaternium-73 have a synergistic antibacterial effect, are not easy to generate drug resistance, and can promote wound repair, and the addition of the humectant enables the wound to better keep a moist environment, and does not cause secondary damage to the skin.
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Description

technical field

[0001] The invention belongs to the field of biomedical dressings, and in particular relates to a low-pressure in-situ antibacterial and repair-promoting electrospun dressing and a preparation method thereof. Background technique

[0002] Acute wounds refer to wounds that form suddenly and can heal within 4-8 weeks, and the pathological development conforms to the classic wound repair process. Once the wound healing process is hindered by certain factors, such as ischemia, infection, dryness, etc., the wound healing process will be delayed or even stagnated, eventually forming a chronic non-healing wound. The occurrence of acute wounds is often accompanied by severe trauma and bleeding, which is likely to be life-threatening, and its timely treatment and care are urgent.

[0003] Maintaining a good local wound environment is essential for wound healing. Studies have shown that a moist wound environment can prevent cell dehydration, stimulate cell migration ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
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