Monatomic catalyst, preparation method thereof, microelectrode and preparation method and application of microelectrode

A technology of catalyst and microelectrode, which is applied in the fields of single-atom catalyst and its preparation, microelectrode and its preparation, can solve the problem of low selectivity of hydrogen peroxide, achieve the effect of improving catalytic performance, simple operation and easy implementation

Active Publication Date: 2021-12-14
INST OF CHEM CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although there are many electrochemical techniques for the detection of hydrogen peroxide through electrocatalytic hydrogen peroxide reduction (HPRR), there are still many problems in the in vivo analysis of hydrogen peroxide.
For example, traditional electrocatalysts represented by Pt are often interfered by substances such as O2, resulting in low selectivity of the catalyst to hydrogen peroxide.

Method used

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  • Monatomic catalyst, preparation method thereof, microelectrode and preparation method and application of microelectrode
  • Monatomic catalyst, preparation method thereof, microelectrode and preparation method and application of microelectrode
  • Monatomic catalyst, preparation method thereof, microelectrode and preparation method and application of microelectrode

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0051] single atom catalyst Cu 1 / mpg -C 3 N 4 Preparation of:

[0052] Cyanamide (5g) and AS-40 colloidal silica (12.5 g) was mixed together and stirred until the suspension became clear. The mixture was heated at 100°C for several hours until the water evaporated completely and a white solid formed. Then the white solid was ground into powder, transferred to a crucible, raised to 550 °C in air at a rate of 2.3 °C / min, and then treated at 550 °C for 4 h. After cooling down, add 4mol / L NH to the obtained yellow powder 4 HF 2 solution and stirred for 2 days. Then centrifuge and wash the pellet with distilled water and ethanol. The yellow compound after centrifugation was vacuum dried overnight at 120°C to obtain mpg-C 3 N 4 .

[0053] Cu(NO 3 ) 2 Solution (10mg / mL) was added to mpg-C 3 N 4 Dispersion (4mg / mL), stirred for about 24 hours, centrifuged to obtain Cu(NO 3 ) 2 / mpg -C 3 N 4 . The precipitate was then washed several times with water and ethanol, a...

Embodiment 2

[0059] Using the microelectrode obtained in Example 1 to detect hydrogen peroxide concentration in vivo

[0060] 1. In order to verify the selectivity of microelectrodes in vitro to hydrogen peroxide, the inventors compared the responses of common interfering substances in the brain on the electrodes. refer to Figure 4A and Figure 4B , apply a voltage of 0V to the working electrode, and after the current is stable, add the electrolyte solution (artificial cerebrospinal fluid is used here, abbreviated as aCSF, its composition is NaCl (126mmol / L), KCl (2.4mmol / L), KH 2 PO 4 (0.5mmol / L), MgCl 2 (0.85mmol / L), NaHCO 3 (27.5mmol / L), Na 2 SO 4 (0.5mmol / L), CaCl 2 (1.1mmol / L), used to simulate the cerebrospinal fluid environment), add 10μmol / L dopamine (DA) solution, 10μmol / L dihydroxyphenylacetic acid (DOPAC) solution, 10μmol / L serotonin (5-HT) solution, 10μmol / L of norepinephrine (NE) solution, 10 μmol / L of uric acid (UA) solution, 50 μmol / L of oxygen (O 2 ) solution, no...

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Abstract

The invention relates to a monatomic catalyst. The monatomic catalyst comprises graphite-phase carbon nitride serving as a carrier, and copper monatomic serving as an active component loaded on the carrier, wherein the atom percentage content of the active component in the monatomic catalyst is 0.07 to 0.2 percent; and the graphite phase carbon nitride is mpg-C3N4. The invention also relates to a microelectrode. The microelectrode comprises an electrode, a composite layer which coats the surface of the electrode, and a polymer layer for covering the composite layer, wherein the composite layer comprises the monatomic catalyst or a mixture of the monatomic catalyst and a carbon material. The monatomic catalyst is large in specific surface area, low in active component content, high in hydrogen peroxide selectivity and good in stability. The microelectrode provided by the invention adopts the monatomic catalyst with high selectivity as an electrocatalyst, realizes accurate detection of hydrogen peroxide on the electrode, and is not interfered by oxygen and other majority of substances in the brain at the same time.

Description

technical field [0001] The invention relates to the field of materials and electroanalytical chemistry, in particular to a single-atom catalyst and its preparation method, a microelectrode containing it, its preparation method and application. Background technique [0002] In brain neurochemistry, H 2 o 2 As a reactive oxygen species (ROS), it is generally regarded as a potential toxin because it can be converted into highly reactive OH radicals under certain conditions, thereby damaging structures such as proteins, DNA, and lipids. In addition, hydrogen peroxide, as a neuromodulator, also plays an important role in signal transduction, and has received more and more attention in the study of brain cell function. Therefore, in vivo hydrogen peroxide monitoring with high spatiotemporal resolution is of great significance in both physiological and pathological studies. Although there are many electrochemical techniques for the detection of hydrogen peroxide through electroc...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01J27/24B01J23/72B01J35/10G01N27/30
CPCB01J27/24B01J23/72B01J35/1019B01J35/0033G01N27/308
Inventor 毛兰群高小龙马文杰于萍
Owner INST OF CHEM CHINESE ACAD OF SCI
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