Copper peroxide transdermal microneedle system and preparation method and application thereof

A technology of copper peroxide and microneedle, which is applied in the direction of chemical instruments and methods, active ingredients of peroxide, microneedle, etc., can solve the problems of low safety and poor treatment effect of superficial tumors, and achieve great attraction, Enhancement of tumor suppressive effect and effect of safe cancer treatment

Inactive Publication Date: 2021-12-21
SHANGHAI INST OF CERAMIC CHEM & TECH CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The copper peroxide transdermal microneedle system and its preparation method should solve the technical problems of poor treatment effect and low safety on superficial tumors in the prior art

Method used

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  • Copper peroxide transdermal microneedle system and preparation method and application thereof
  • Copper peroxide transdermal microneedle system and preparation method and application thereof
  • Copper peroxide transdermal microneedle system and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0045] Example 1 Preparation of a copper oxide nanoparticle:

[0046] 2G Polyvinylpyrone (MW1000) and 34.1 mgcuCl 2 · 2h 2 O, add to 20 ml of deionized water to completely dissolve; a 20 ml of molar concentration of 0.02 m aqueous sodium hydroxide solution was formed, and slowly added to the above solution; then added 400 μl of hydrogen peroxide solution (concentration 30 wt%) continued The mixture was stirred for 30 minutes; finally, the product was collected and washed 3 times with deionized water, and then a gas-free iron nanoparticle powder was obtained after the vacuum oven was dried.

[0047] Fig. 1 is a transmission electron micrograph of a peroxide nanoparticle prepared according to the above method, a dynamic light scatter water dynamic size distribution, X-ray diffraction analysis, X-ray photoelectron energy spectrum analysis results, which proves that the dispersibility is prepared. Peroxidation Copper nanoparticles.

Embodiment 2

[0049] 2 is a correlation performance test of a peroxide nanoparticle prepared in Example 1 of the present invention.

[0050] According to 3, 3 ', 5,5'-tetramethyleneliphenylamine (TMB) energy and hydroxyl radical reaction from colorlessness into blue and the reaction product exhibits feature absorption at 654 nm, which is catalyzed as an indicator The fenton-type reaction produces a hydroxyl radical. First, put CU 2+ (1MM), H 2 O 2 (1MM) and CU 2+ (1MM) plus H 2 O 2 (1 mm) A acetate buffer solution (pH 5.2) containing TMB indicator is added, and the ultraviolet absorption spectrum (400 ~ 800 nm) is measured after 5 minutes, respectively. Figure 2A . The results show that only Cu 2+ (1MM) plus H 2 O 2 The (1 mM) group showed a significant feature absorption at 650 nm, which indicates that the copper ion energy catalytic font reaction is transformed into hydroxyl hydrogen peroxide. Next, the peroxide nanoparticles (200 μg / ml) prepared in Example 1 were added to the sodium acetat...

Embodiment 3

[0052] Example 3 Preparation of a copper oxide transparent microneedle system (MN-10%):

[0053] The peroxide nanoparticle powder and polyethylene pyridyl ketone polymer (MW40000) prepared by the preparation of Example 1 were uniformly mixed to form a mixed material having a total mass ratio of 10% of the mixed material at the end of the mixture. Further, the appropriate amount of deionized water is added, and a mixed slurry that is mixed, a mixed slurry is mixed; then the mixed slurry is added to the polymethyl silicide micro-needle mold (purchased from Singapore MicropointTechnologiesPTE Co., Ltd.) To make the mixed slurry cover the entire microneedle mold cavity; place the micro-needle mold equipped with a mixed slurry in a vacuum oven to vacuo to -0.1 MPa and remain in 1 minute, and it can be observed in the slurry. Obvious bubbles, indicating that the mixed slurry was filled into the tip tip; then, the extra mixed slurry of the microneedle mold cavity was removed, and the mix...

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Abstract

The invention relates to a copper peroxide transdermal microneedle system and a preparation method and application thereof. The copper peroxide transdermal microneedle system comprises a microneedle substrate and at least one microneedle body distributed on the microneedle substrate, and each microneedle body comprises a matrix and copper peroxide nanoparticles.

Description

Technical field [0001] The present invention relates to a peroxide-transparent microneedle system and a preparation method thereof, in particular to a micro-needle-resistant polymeric material, a biocompatible polymeric material, and a transdermal of copper-based nanoparticles. Micro-needle system, with good transdermal and water soluble, transparent delivery of copper oxide nanoparticles to superficial tumor area, combined with self-enhanced chemical kinetics and photothermal therapy to achieve enhanced tumor therapy effect, in the anti-shallow surface Tumors have potential application value and belong to the field of biomaterials. Background technique [0002] Cancer is one of the major diseases that threaten human health, and the incidence and mortality have an annual increase. Among them, superficial tumors, such as melanoma, is a tumor with very high malignant. Commonly used treated treated methods for shallow layer tumors is surgical resection, radiotherapy, and pharmaceuti...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K41/00A61K33/40A61K9/00A61K47/10A61K47/32A61K47/34A61K47/36A61M37/00A61P35/00B82Y5/00C01B15/047
CPCA61K41/0052A61K33/40A61K9/0021A61K47/32A61K47/10A61K47/36A61K47/34A61P35/00B82Y5/00A61M37/0015C01B15/047A61M2037/0053A61M2037/0046C01P2004/04C01P2002/70C01P2002/72C01P2004/03
Inventor 朱钰方陈佳杰吴成铁
Owner SHANGHAI INST OF CERAMIC CHEM & TECH CHINESE ACAD OF SCI
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