Construction method of 3D printing titanium alloy stent with photo-thermal and temperature control warning functions
A 3D printing and construction method technology, which is applied in the fields of pharmaceutical formulation, medical science, tissue regeneration, etc., can solve problems such as poor treatment efficacy, inability to monitor lesion temperature in real time, and difficulty in synchronously realizing anti-tumor/bone repair, etc., to achieve osteogenesis Performance repair, control of tumor recurrence and metastasis
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Embodiment 1
[0054] The steps of this embodiment are as follows:
[0055] (1) Construction of titanium alloy stent surface structure / component double biomimetic coating:
[0056] Hydrofluoric acid, nitric acid, and water were prepared according to a volume ratio of 1:3:5 to prepare an acid etching treatment solution.
[0057] The 3D printed porous titanium alloy Ti64 scaffold was acid-etched in the acid-etching treatment solution for 1 min. After the acid-etching treatment, it was ultrasonically cleaned with acetone, absolute ethanol and ultrapure water respectively. The ultrasonic cleaning time was 10 min, and dried. After that, put it in 50mL H 2 o 2 and H 3 PO 4 in the mixed aqueous solution (wherein H 2 o 2 The mass concentration is 27%, H 3 PO 4 mass concentration of 3%), after hydrothermal reaction at 200°C and 100kPa for 20h, wash and dry, and then place it in 50mL of CaCl with a concentration of 0.2g / mL 2 In the solution, the secondary hydrothermal reaction was carried out...
Embodiment 2
[0065] The steps of this embodiment are as follows:
[0066] (1) Construction of titanium alloy stent surface structure / component double biomimetic coating:
[0067] Hydrofluoric acid, nitric acid and water are prepared according to the volume ratio of 2:4:5 to prepare an acid etching treatment solution.
[0068] The 3D printed porous titanium alloy Ti64 stent was acid-etched in the acid-etching treatment solution for 2 minutes. After the acid-etching treatment, it was ultrasonically cleaned with acetone, absolute ethanol and ultrapure water respectively. The ultrasonic cleaning time was 20 minutes, and dried. After that, put it in 50mL H 2 o 2 and H 3 PO 4 in the mixed aqueous solution (wherein H 2 o 2 The mass concentration is 20%, H 3 PO 4 mass concentration of 10%), after hydrothermal reaction at 210°C and 110kPa for 22h, wash and dry, and then place it in 50mL of CaCl with a concentration of 0.4g / mL 2 In the solution, the secondary hydrothermal reaction was carri...
Embodiment 3
[0074] The steps of this embodiment are as follows:
[0075] (1) Construction of titanium alloy stent surface structure / component double biomimetic coating:
[0076] Hydrofluoric acid, nitric acid and water are prepared according to the volume ratio of 2:3:5 to prepare an acid etching treatment solution.
[0077] The 3D printed porous titanium alloy Ti64 stent was acid-etched for 3 minutes. After acid-etching, it was ultrasonically cleaned with acetone, absolute ethanol and ultrapure water respectively. The cleaning time was 30 minutes. After drying, it was placed in 50 mL h 2 o 2 and H 3 PO 4 in the mixed aqueous solution (wherein H 2 o 2 The mass concentration is 3%, H 3 PO 4 mass concentration of 9%), after hydrothermal reaction at 220°C and 120kPa for 24h, washed and dried, and then placed in 50mL of CaCl with a concentration of 0.6g / mL 2 In the solution, the secondary hydrothermal reaction was carried out under the conditions of 120° C. and 90 kPa for 8 hours, an...
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Abstract
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