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Compound dexamethasone acetate cream and preparation method thereof

A technology of dexamethasone acetate and cream, applied in ointment delivery, pharmaceutical formula, emulsion delivery, etc., can solve the problems of poor effect and weak antibacterial effect, achieve low allergenicity, high safety, overcome The effect of insufficient antibacterial potency

Pending Publication Date: 2022-01-04
GUANGZHOU PHARMACEUTICAL INDUSTRIAL RESEARCH INSTITUTE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] To improve the antibacterial effect of cream, you can use antibacterial agents with strong antibacterial effect, use different antibacterial agents or antibacterial agents in combination with antibacterial synergists (such as propylene glycol) and antioxidants (such as butyl hydroxytoluene, Butylated hydroxyanisole and EDTA), etc., but the bacteriostatic effect mainly depends on the bacteriostatic agent. If the bacteriostatic effect of the bacteriostatic agent is weak, the bacteriostatic effect can be improved by adding antibacterial synergists and antioxidants , the effect is generally poor

Method used

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  • Compound dexamethasone acetate cream and preparation method thereof
  • Compound dexamethasone acetate cream and preparation method thereof
  • Compound dexamethasone acetate cream and preparation method thereof

Examples

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Effect test

Embodiment 1

[0038] Embodiment 1 A kind of compound dexamethasone acetate cream and preparation method thereof

[0039]In the compound dexamethasone acetate cream of the present embodiment, the antibacterial agent used is ethylparaben, and the ethylparaben accounts for 0.4% of the weight of the compound dexamethasone acetate cream.

[0040] The prescription components of compound dexamethasone acetate cream are as follows:

[0041] Raw materials content(%) Dexamethasone acetate 0.075 Camphor 1 Menthol 1 Carbomer 980NF 0.2 Polyoxyl(40) Stearate 1 Sodium dodecyl sulfate 1 Glyceryl monostearate 5 liquid paraffin 5 cetostearyl alcohol 9 White Vaseline 2 Ethylparaben 0.4 Propylene Glycol 1.5 glycerin 3.5 Triethanolamine Appropriate amount essence 0.15 purified water Top up to 100%

[0042] The preparation method of the compound dexamethasone acetate cream of the present embodiment ma...

Embodiment 2

[0048] Embodiment 2 A kind of compound dexamethasone acetate cream and preparation method thereof

[0049] The compound dexamethasone acetate cream of the present embodiment, the bacteriostatic agent that uses is methylparaben and propylparaben, and described methylparaben accounts for 0.36% of described compound recipe dexamethasone acetate cream weight, and hydroxybenzoate Phenylpropyl ester accounts for 0.04% of the weight of the compound dexamethasone acetate cream.

[0050] The prescription components of compound dexamethasone acetate cream are as follows:

[0051]

[0052]

[0053] The preparation method of the compound dexamethasone acetate cream of the present embodiment may further comprise the steps:

[0054] (1) Preparation of the oil phase: weigh glyceryl monostearate, light liquid paraffin, cetostearyl alcohol and white petrolatum according to the prescription, put them in a beaker, heat to 80°C-85°C, and wait until completely melted , add methylparaben an...

Embodiment 3

[0059] Embodiment 3 A kind of compound dexamethasone acetate cream and preparation method thereof

[0060] The compound dexamethasone acetate cream of the present embodiment, the antibacterial agent that uses is methylparaben and propylparaben, and described methylparaben accounts for 0.315% of described compound dexamethasone acetate cream weight, and hydroxybenzoate Phenylpropyl ester accounts for 0.035% of the weight of the compound dexamethasone acetate cream.

[0061] The prescription components of compound dexamethasone acetate cream are as follows:

[0062] Raw materials content(%) Dexamethasone acetate 0.075 Camphor 1 Menthol 1 Carbomer 980NF 0.2 Polyoxyl(40) Stearate 2 Glyceryl monostearate 5 liquid paraffin 8 cetyl alcohol 8 Methylparaben 0.315 Propylparaben 0.035 Propylene Glycol 1.5 glycerin 3.5 sodium bicarbonate Appropriate amount Edetate disodium 0.1 essence 0.1...

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PUM

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Abstract

The invention discloses compound dexamethasone acetate cream and a preparation method thereof. The cream contains a bacteriostatic agent accounting for 0.35-0.45% of the weight of the cream, and the bacteriostatic agent is a mixture of methylparaben and propyl hydroxybenzoate, or the bacteriostatic agent is ethylparaben. The compound dexamethasone acetate cream disclosed by the invention has strong bacteriostatic efficacy on candida albicans, aspergillus niger, escherichia coli, pseudomonas aeruginosa and staphylococcus aureus, the bacteriostatic efficacy meets the requirements of the 2015 edition Chinese pharmacopoeia, the defect that the existing compound dexamethasone acetate cream is insufficient in bacteriostatic efficacy is overcome, and the compound dexamethasone acetate cream is strong in stability, relatively low in skin allergenicity, and high in safety.

Description

technical field [0001] The invention belongs to the technical field of pharmacy, and more specifically, the invention relates to a compound dexamethasone acetate cream and a preparation method thereof, and a method for improving the antibacterial effect of the compound dexamethasone acetate cream. Background technique [0002] The active ingredients of the compound dexamethasone acetate cream are dexamethasone acetate, camphor and menthol, which are used to treat localized pruritus, neurodermatitis, contact dermatitis, seborrheic dermatitis and chronic eczema. It belongs to the oil-in-water cream and is a multi-dose skin medicine. It needs to be opened repeatedly during use. Therefore, in order to avoid harm to the user due to exogenous pollution, a certain amount of bacteriostatic agent needs to be added to prevent the preparation During normal storage or use, due to microbial contamination and reproduction, the drug will deteriorate and cause harm to the user. [0003] Th...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/573A61K9/06A61K47/14A61K47/32A61P31/04A61K31/045A61K31/125
CPCA61K9/06A61K31/573A61K31/125A61K31/045A61K47/14A61K47/32A61P31/04A61K2300/00Y02A50/30
Inventor 蔡蕙倪庆纯孙晶晶谢志宏李美林孙秀玲陈溪黄芷茵
Owner GUANGZHOU PHARMACEUTICAL INDUSTRIAL RESEARCH INSTITUTE
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