Synthesis method of chlorantraniliprole

Abstract

The invention discloses a synthesis method of chlorantraniliprole, and relates to the field of synthesis of pesticide chlorantraniliprole. The synthesis method comprises the following steps: step 1, firstly preparing a four-neck flask, adding 3-bromo-1-(3-chloro-2-pyridyl)-1-hydro-pyrazole-5-formic acid, and uniformly conducting stirring. The method takes 3-bromo-1-(3-chloro-2-pyridyl)-1-hydro-pyrazole-5-formic acid as an initial raw material, adopts an acylating chlorination reagent and takes methylbenzene, acetonitrile or dichloroethane (preferably methylbenzene) as a solvent, acylating chlorination reaction is conducted to synthesize an acyl chloride methylbenzene solution of the acid, and 2-amino-5-chloro-N,3-dimethylbenzamide is added into the acyl chloride methylbenzene solution without separation, and reflux reaction is conducted to obtain a chlorantraniliprole product. According to the present invention, the yield of the chlorantraniliprole produced by using the method is substantially improved, the wastewater generation amount and the treatment difficulty are reduced, the production quality is improved, the economic benefits are increased, and the large-scale production is easily achieved.

Description

technical field [0001] The invention relates to the field of synthesizing the pesticide chlorantraniliprole, in particular to a method for synthesizing chlorantraniliprole. Background technique [0002] The pesticide residues in agricultural products and the toxicity to animals have always been a hot spot of concern. In recent years, DuPont has successfully developed various high-efficiency and low-toxicity pesticides, which are changing the impact of pesticides on the environment. Insecticide research and development successfully led to chlorantraniliprole. Chlorantraniliprole has strong permeability and systemic conductivity. The pesticide that enters the plant is transmitted along the xylem to other parts that have not been applied, which is beneficial to the protection of newborn tissues. ; Stomach toxicity is the main type, followed by contact action; long-lasting effect, resistant to rain erosion. [0003] Find according to retrieval, the Chinese patent that the paten...

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Problems solved by technology

[0003] Find according to retrieval, the Chinese patent that the patent No. is CN_101072767_A discloses the method for preparing N-phenylpyrazole-1-carboxamide, and it uses 3-bromo-1-(3-chloro-2-pyridyl)-1 hydrogen- Chlorantraniliprole (3-bromo-N-[4-chloro-2-methyl-6- (Methylcarbamoyl) benzene]-1-(3-chloropyridin-2-yl)-1H-pyrazole-5-carboxamide), using reagents such as pyridine, methanesulfonyl chloride, acetonitrile, a large amount of pyridine-containing , sodium chloride, sodium methanesulfonate to obtain high-salt wastewater, pyridine recovery and wastewater treatment costs are very high

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