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Composition comprising grain-derived lactic acid bacteria for relieving hangover and bowel trouble

A composition and technology of lactic acid bacteria, applied in the directions of bacteria, lactobacillus, application, etc. used in food preparation, can solve the problems of unsolved intestinal problems and insignificant effects, etc.

Pending Publication Date: 2022-01-11
WELL BEING LS CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0010] Therefore, if ingesting lactic acid bacteria with alcohol dehydrogenase and acetaldehyde dehydrogenase secretion ability or the useful substances inside the cells that can increase the activity of alcohol dehydrogenase and acetaldehyde dehydrogenase and lactic acid bacteria with lactic acid bacteria producing substances, then due to the Helps break down alcohol in the small intestine and can reduce the amount of alcohol transported to the liver, thereby helping to eliminate hangovers. Currently, related products are being produced, but they have the disadvantage of not being effective
[0011] On the other hand, although most people complain about intestinal problems such as abdominal pain, nausea, and diarrhea while complaining about a hangover after drinking alcohol, there are currently no products that solve intestinal problems

Method used

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  • Composition comprising grain-derived lactic acid bacteria for relieving hangover and bowel trouble
  • Composition comprising grain-derived lactic acid bacteria for relieving hangover and bowel trouble
  • Composition comprising grain-derived lactic acid bacteria for relieving hangover and bowel trouble

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Embodiment approach

[0030] In the course of trying to find lactic acid bacteria that secrete alcohol dehydrogenase and acetaldehyde dehydrogenase that are enzymes that interfere with alcohol metabolism in the small intestine and liver, or increase their activity, and a composition for eliminating hangovers containing the same, the present invention People found that Lactobacillus fermentum JS with patent preservation number KCCM-10499 can secrete alcohol dehydrogenase and acetaldehyde dehydrogenase or increase their activity, thus completing the present invention.

[0031] That is, the present invention provides a hangover-relief composition comprising a grain-derived lactic acid bacterium Lactobacillus fermentum JS strain having alcohol dehydrogenase and acetaldehyde dehydrogenase Enzyme secretion and / or enzyme activity increasing capacity.

[0032] The composition for eliminating hangover of the present invention comprises Lactobacillus fermentum JS with patent deposit number KCCM-10499, which ...

Embodiment 1

[0058] Example 1. Confirmation of alcohol-resistant bacterial strains

[0059] In order to obtain the hangover-removing effect, the strain needs to be able to proliferate in the small intestine where the alcohol concentration is high, so an alcohol-resistant strain was selected. The medium used to confirm the alcohol resistance of the strain is a medium in which 5.5% of MRS was dissolved in fermented alcohol diluted to an alcohol concentration of 10%, 15%, 20%, 25%, and 30%. Culture medium (deMan, Rogosa & Sharpe) powder and utilize membrane filter (membrane filter) to carry out the culture medium that sterilizes 20ml of its liquid culture medium.

[0060] Inoculate 1% of 1.0×10 9 Candidate strains were freeze-dried at a concentration of cfu / g and cultured statically at 37°C. Subsequently, alcohol tolerance was confirmed by comparing the growth degree in ordinary MRS medium and MRS medium mixed with fermented alcohol. The degree of growth of the strain was confirmed by measu...

Embodiment 2

[0066] Example 2. Determination of the alcohol dehydrogenase and acetaldehyde dehydrogenase activities of the strains whose alcohol resistance is the top 8.

[0067] The activity of alcohol dehydrogenase is expressed by measuring the reduced coenzyme (NADH, Nicotinamide adenine dinucleotide) formed when alcohol is decomposed in the absorbance of 340nm using a UV-visible spectrophotometer.

[0068] Add 100 μl of 99% ethanol, 500 μl of nicotinamide adenine dinucleotide (NAD, Nicotinamide adenine dinucleotide) aqueous solution, 100 μl of 1.0×10 8After the candidate strains at cfu / ml concentration, add 1.1ml of 0.01M glycine (glycine)-NaOH buffer solution (pH8.8) to make the total volume reach 1.8ml, then react in a constant temperature water tank at 25°C for 10 minutes. After completion of the reaction, 250 µl of alcohol dehydrogenase was added and the change in absorbance was measured at 340 nm, while the control group was placed in distilled water instead of the sample. As a p...

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Abstract

The present invention relates to a composition for relieving hangover, the composition comprising the grain-derived lactic acid bacterium strain Lactobacillus fermentum JS with an accession number of KCCM-10499 which exhibits a potential of increasing enzymatic activity of alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH), and to a composite lactic acid bacterium composition for relieving hangover, the composition comprising the seven lactic acid bacterium species, namely Lactobacillus plantarum, Lactobacillus casei, Lactobacillus rhamnosus, Lactobacillus acidophilus, Lactococcus lactis, Bifidobacterium breve, and Bifidobacterium lactis, which, although low in the potential of increasing enzymatic activity of ADH and ALDH, exhibit synergy effects when used in combination with the grain-derived lactic acid bacterium strain Lactobacillus fermentum JS with an accession number of KCCM-10499.

Description

technical field [0001] The present invention relates to a composition for eliminating hangovers, which comprises a grain-derived lactic acid bacterium Lactobacillus fermentum JS (Lactobacillus fermentum JS) strain with a patent preservation number of KCCM-10499, and the grain-derived lactic acid bacterium Lactobacillus fermentum JS strain has Enzyme activity and / or enzyme activity increasing ability of alcohol dehydrogenase (ADH, alcohol dehydrogenase) and acetaldehyde dehydrogenase (ALDH, aldehyde dehydrogenase). And, the present invention relates to a composition for eliminating hangovers, which comprises Lactobacillus plantarum (Lactobacillus plantarum), Lactobacillus casei (Lactobacillus casei), Lactobacillus rhamnosus (Lactobacillus rhamnosus), Lactobacillus acidophilus acidophilus), Lactococcus lactis (Lactococcus lactis), Bifidobacterium breve (Bifidobacterium breve) and lactobacillus (Bifidobacterium lactis) composed of more than one lactic acid bacteria, although the ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A23L33/135
CPCA61K35/744A61K35/747A61P25/32A61K35/745A23L33/135A23V2200/334A23V2200/32A23V2400/11
Inventor 朴宗洵李东陈李得植
Owner WELL BEING LS CO LTD
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