Aminomethylbenzoic acid injection and preparation method thereof
A technology of aminotoluic acid and injection, which is applied in the field of medicinal chemistry, can solve the problems of long time-consuming filtration of aminotoluic acid raw materials, low porosity of polyethersulfone filter membrane, and poor pore interconnection, etc., to improve permeability and porosity The effect of enhancing and reducing the cost of filtration
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Embodiment 1
[0026] The modified polyether sulfiltration membrane includes the following steps:
[0027] A. Soak the polyether sulfone filter in the mixture of 30 times the compound of the self-mass, 3 h, ethanol and sodium hydroxide solution in the mixture of 3 h, ethanol and sodium hydroxide solution, and remove the polyethersulfone filter, after filtering, Wash and drying to obtain a surface hydroxylated polyether sulfone filter;
[0028] B, 3.22 g of tetraalkyl trimethylcylammonium chloride and 2.02 ml of sodium chloride were added to 420 g of deionized water and 420 g of methanol, stirred until hexadalkyltrimethylammonium chloride dissolved, and added drop with stirring 1.03 g of tetraethoxysilane continued to stir for 6 h, then allowed to stand overnight, was collected by centrifugation and washed with acetanol and acetone, then calcined at 500 ° C for 4 h to obtain a mesh silica;
[0029] C, 44 mg of the mesoporous silica was dispersed in 8 ml of toluene containing 0.8 ml of an amino si...
Embodiment 2
[0032] The modified polyether sulfiltration membrane includes the following steps:
[0033] A. Soak the polyether sulfone filter in ethanol and a sodium hydroxide solution in the mixture of 40 times the hydroxide solution in the mixture of 40 times the mixture of 50 times the sodium hydroxide solution. Wash and drying to obtain a surface hydroxylated polyether sulfone filter;
[0034] B, 3.82 g of tetraalkyl trimethylcylammonium chloride and 3.12 ml of sodium chloride were added to 384 g of methanol, stirred until hepotena-based trimethyl chloride dissolved, add drop with stirring 1.44 g of tetraethoxysilane continued to stir for 6 h, then allowed to stand overnight, the solid was collected by centrifugation and washed with acetanol and then calcined at 500 ° C for 4 h, resulting in the mesoporous silica;
[0035] C, 63 mg of the mesoon dioxide was dispersed in 12 ml of toluene containing 1.2 ml of an amino silane reagent to obtain a suspension, and then the suspension was refluxe...
Embodiment 3
[0038] A amtroductomoate injection, with a mass share, including the following raw materials: 4.1 parts of methylene 1, 6.3 sodium chloride, 0.05 parts of sodium sodium, 72 parts of injection.
[0039] Method for preparing ammoke injection injection, including the steps of:
[0040] S1, weigh the material of the formulation;
[0041] S2, 50% injection is heated to 80 ° C, add ammonium carbellic acid, sodium chloride, sodium sodium chloride, stirred, and then dissolved, then the dilute hydrochloric acid is adjusted to 3.7, coarse filtrate, reflow to obtain a crude filter;
[0042] S3, adding the remaining amount of water in the obtained crude filtration and stirring, mixing uniform, crystallite, refluxed to obtain a refined filtrate, refined filtration using the modified polyether sulfid filter prepared by Example 1;
[0043] S4, fine filtration fluid through potting, sterilization, leak detection, lamp inspection, printing, packaging and storage,
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