Structural design and preparation method of double-layer drug sustained-release hydrogel dressing
A technology of structural design and hydrogel, which is applied in the field of structural design and preparation of double-layer slow-release dressings, can solve the problems of reducing the therapeutic effect of hydrogel and destroying the integrity of the low-strength hydrogel network structure, and achieves good results. Anti-inflammatory and analgesic effects, reduction of inflammatory edema and traumatic edema, and sustained-release effects
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Embodiment 1
[0042] A preparation method of a double-layer slow-release hydrogel dressing, comprising the steps of:
[0043] Step (1) Dissolve 2.25g of sodium hydroxide in 15ml of deionized water, then stir until completely dissolved at room temperature, then add 10g of β-cyclodextrin into the solution, and stir overnight to activate the β-cyclodextrin;
[0044] Step (2) Heat the solution in step (1) to 35° C., add 6 ml of epichlorohydrin solution therein, and continue the reaction for 200 min. After the reaction in step (3) is completed, add a sufficient amount of acetone to the solution in step (2) to terminate the reaction, shake it up, put it into a separatory funnel and let it stand for 30 minutes to separate layers, and collect the lower layer liquid;
[0045] Step (4) adjust the pH of the liquid collected in step (3) to 7 with hydrochloric acid solution, then dialyze in deionized water with a 1000 Da dialysis bag for 7 days, and finally freeze-dry to obtain a β-cyclodextrin polymer;...
Embodiment 2
[0053] A preparation method of a double-layer slow-release hydrogel dressing, comprising the steps of:
[0054] Step (1) Dissolve 2.25g of sodium hydroxide in 15ml of deionized water, then stir until completely dissolved at room temperature, then add 10g of β-cyclodextrin into the solution, and stir overnight to activate the β-cyclodextrin;
[0055] Step (2) Heat the solution in step (1) to 35° C., add 6 ml of epichlorohydrin solution therein, and continue the reaction for 200 min. After the reaction in step (3) is completed, add a sufficient amount of acetone to the solution in step (2) to terminate the reaction, shake it up, put it into a separatory funnel and let it stand for 30 minutes to separate layers, and collect the lower layer liquid;
[0056] Step (4) adjust the pH of the liquid collected in step (3) to 7 with hydrochloric acid solution, then dialyze in deionized water with a 1000 Da dialysis bag for 7 days, and finally freeze-dry to obtain a β-cyclodextrin polymer;...
Embodiment 3
[0064] A preparation method of a double-layer slow-release hydrogel dressing, comprising the steps of:
[0065] Step (1) Dissolve 2.25g of sodium hydroxide in 15ml of deionized water, then stir until completely dissolved at room temperature, then add 10g of β-cyclodextrin into the solution, and stir overnight to activate the β-cyclodextrin;
[0066] Step (2) Heat the solution in step (1) to 35° C., add 6 ml of epichlorohydrin solution therein, and continue the reaction for 200 min. After the reaction in step (3) is completed, add a sufficient amount of acetone to the solution in step (2) to terminate the reaction, shake it up, put it into a separatory funnel and let it stand for 30 minutes to separate layers, and collect the lower layer liquid;
[0067] Step (4) adjust the pH of the liquid collected in step (3) to 7 with hydrochloric acid solution, then dialyze in deionized water with a 1000 Da dialysis bag for 7 days, and finally freeze-dry to obtain a β-cyclodextrin polymer;...
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