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Yeast powder rich in nicotinamide mononucleotide as well as preparation method and application thereof

A single nucleotide and yeast powder technology, applied in the field of yeast powder, can solve the problems of reduced NAD+ content and inability to directly obtain NAD

Pending Publication Date: 2022-03-01
TCI CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] However, NAD cannot be obtained directly from the diet + , and as humans age, NAD naturally produced in the body + content reduction

Method used

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  • Yeast powder rich in nicotinamide mononucleotide as well as preparation method and application thereof
  • Yeast powder rich in nicotinamide mononucleotide as well as preparation method and application thereof
  • Yeast powder rich in nicotinamide mononucleotide as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0098] Example 1: Fermentation process - preparation of yeast powder rich in nicotinamide mononucleotide (NMN)

[0099] Prepare the fermentation medium and divide it into the first medium, the second medium and the third medium according to the order of fermentation. Here, the fermentation medium is composed of basal medium, niacinamide, tryptophan, and niacin, and its composition is 2.0% yeast peptone (English trade name: Yeast peptone GLS; manufacturer: Shangding Biotechnology Co., Ltd.), 2.0% yeast extract 902 (English trade name: Angel yeast extract 902; manufacturer: Deen Biomedical Co., Ltd.), 0.5% potassium dihydrogen phosphate (manufacturer: Sigma-Aldrich Company), 0.5% % dipotassium hydrogen phosphate (manufacturer: Xie Ming Chemical Co., Ltd.), 0.05% magnesium sulfate (manufacturer: Jinglian Industrial Co., Ltd.), 10% glucose (manufacturer: Yue Yuen Industrial Co., Ltd.), 0.17% Citric acid (manufacturer: Shinwa Food Co., Ltd.), 0.5% sodium acetate (manufacturer: Shi...

example 2

[0104] Example 2: Fermentation Process - Yeast Strain Test

[0105] Here, the nicotinamide mononucleotide (NMN) contained in the yeast powder is used as a judgment index.

[0106] The experimental group is the yeast powder prepared in Example 1, and the yeast strain used is Saccharomyces cerevisiae TCI907.

[0107] The yeast powder of control group is according to the preparation process of example 1 but the yeast powder prepared by replacing the bacterial classification used in example 1. That is to say, the difference between the preparation process of the control group and the preparation process of Example 1 is that the yeast strain used is Torula jadinii (Cyberlindnera jadinii) (purchased from the biological resource preservation and Research Center, registration number is BCRC20325).

[0108] Dissolve 1 gram of the yeast powder of the experimental group and the control group in 9 grams of water to form a yeast solution, and crush the yeast cells with a cell crusher (br...

example 3

[0113] Example 3: Fermentation Process - Fermentation Medium Test

[0114] Here, the nicotinamide mononucleotide (NMN) contained in the yeast powder is used as a judgment index.

[0115] The experimental group is the yeast powder prepared in Example 1, and the composition of the fermentation medium used is 99.6631% basal medium, 0.1% nicotine amide (NAM), 0.2% tryptophan ) and 0.0369% niacin. Among them, the composition of the basal medium is 2.0% yeast peptone GLS, 2.0% yeast extract 902, 0.5% potassium dihydrogen phosphate (KH 2 PO 4 ), 0.5% dipotassium hydrogen phosphate (KH 2 PO 4 ), 0.05% magnesium sulfate (MgSO 4 ·7H 2 O), 10% glucose (Glucose), 0.17% citric acid (Citric acid), 0.5% sodium acetate (Sodium acetate), 0.016% manganese gluconate (manganese gluconate), 0.1% cysteine ​​( Cysteine), 0.05% defoamer and deionized distilled water (up to 99.6631%).

[0116] The yeast powder of control group is according to the preparation process of example 1 but the yeast ...

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Abstract

The invention discloses yeast powder rich in nicotinamide mononucleotide as well as a preparation method and application of the yeast powder. The preparation method comprises the following steps: preparing a first culture medium, a second culture medium and a third culture medium, inoculating saccharomycetes into the first culture medium for fermentation to obtain first fermentation liquor, and inoculating the first fermentation liquor into the second culture medium for fermentation to obtain second fermentation liquor, inoculating the second fermentation liquor into a third culture medium for fermentation to obtain third fermentation liquor, centrifuging the third fermentation liquor to obtain a fermented product, and drying the fermented product to obtain yeast powder. Wherein the first culture medium, the second culture medium and the third culture medium comprise nicotinamide, tryptophan and nicotinic acid. The content of nicotinamide mononucleotide in the yeast powder is at least more than 5000 ppm.

Description

technical field [0001] The present invention relates to a kind of yeast powder, in particular to a preparation method of yeast powder and the yeast powder made by the preparation method, which is rich in nicotinamide mononucleotide and has multiple uses. Background technique [0002] The study found that Nicotinamide Adenine Dinucleotide (Nicotinamide Adenine Dinucleotide; NAD + ) is related to the anti-aging of cells, and NAD + Its main physiological functions include generating more than 95% of energy for life activities, repairing damaged DNA, activating longevity proteins, etc., and as a component for maintaining mitochondrial activity in the body. [0003] However, NAD cannot be obtained directly from the diet + , and as humans age, NAD naturally produced in the body + content decreased. Therefore, in order to replenish and maintain NAD in the body + content, studies have found that NAD+ precursors can be ingested to increase NAD in the body + content. [0004] F...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/064A61K31/706A61P17/00A61P17/14A61P29/00A61P9/00A61P39/06A61P39/00A61P3/06C12N1/16A61K8/9728A61K8/60A61Q19/00A61Q19/08A61Q5/12A61Q5/00
CPCA61K36/064A61K31/706A61P17/00A61P17/14A61P29/00A61P9/00A61P39/06A61P39/00A61P3/06C12N1/16A61K8/9728A61K8/606A61Q19/00A61Q19/08A61Q5/12A61Q5/00A61K2236/19A61K2800/85A61K2300/00A61K38/08A61K36/06A61K36/88A61K36/73A61K36/81A61Q7/00A61K8/64A61K8/675A61K8/492A61K31/455A61K31/405
Inventor 林咏翔吴佩宜
Owner TCI CO LTD
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