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Traditional Chinese medicine gel for promoting tissue regeneration and healing ulcer and preparation method thereof

A kind of ulcer gel and gel technology, which is applied in the field of medicine and achieves the effects of suitable fluidity, good spreadability and good compatibility

Pending Publication Date: 2022-03-08
JIANGXI UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But there is no report on the traditional Chinese medicine gel with the effect of promoting muscle regeneration and healing ulcer

Method used

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  • Traditional Chinese medicine gel for promoting tissue regeneration and healing ulcer and preparation method thereof
  • Traditional Chinese medicine gel for promoting tissue regeneration and healing ulcer and preparation method thereof
  • Traditional Chinese medicine gel for promoting tissue regeneration and healing ulcer and preparation method thereof

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Experimental program
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Effect test

preparation example Construction

[0035] A preparation method of Shengji Yuyang traditional Chinese medicine gel, comprising the following steps:

[0036] 1. Mix Angelica dahurica, Chinese angelica, licorice, Burnet and Cortex Phellodendri into appropriate amount of ethanol, extract by decocting, concentrate and dry into a dry extract;

[0037] 2. Add comfrey to an appropriate amount of ethanol, extract in a water bath at 40°C, combine the extracts, concentrate under reduced pressure to form an extract;

[0038] 3. Dissolve the dry extract and comfrey extract in purified water and set aside;

[0039] 4. Grind dried blood, glycerin, and borneol evenly, then add propylene glycol to grind evenly, and set aside;

[0040] 5. Add carbomer to purified water, fully stir and swell, then add triethanolamine to adjust pH;

[0041] 6. Add the spare materials in steps 3 and 4 to the gel matrix in turn, and stir evenly to obtain the Shengjiyuyou gel;

[0042] Wherein, the parts by weight of the components of Shengjiyuhan...

Embodiment 1

[0047] Choice of gel matrix material:

[0048] (1) Gel formula:

[0049]

[0050]Among them, the gel matrix is ​​selected from the matrix carbomer 980NF, carbomer 940NF, sodium carboxymethylcellulose, hydroxypropylmethylcellulose, chitosan, and poloxamer for screening, and the gel is made according to the formula quantity Substrate: The formability and fineness of the substrate are investigated, so as to optimize the substrate that can be made in a short period of time with good spreadability and hydrophilicity. The results are shown in Table 1.

[0051] Table 1 The performance comparison of gel matrix made of different matrix

[0052]

[0053] It can be seen that the gel prepared by Carbomer 980NF is uniform, fine, glossy, moderately viscous, and can be evenly coated.

Embodiment 2

[0055] Preparation of Shengjiyuyang Traditional Chinese Medicine Gel. The decoction pieces of traditional Chinese medicine used in this example: comfrey, angelica dahurica, licorice, dried blood, burnet, borneol, Phellodendron Phellodendri. The traditional Chinese medicine gel comprises 120 parts by weight of the active ingredient and 1250 parts by weight of the gel base, and the active ingredient is made of the following raw materials in parts by weight:

[0056] Among them, the active ingredients of the drug are as follows:

[0057]

[0058] Gel formulation:

[0059]

[0060] Preparation:

[0061] 1. Add 8 times the amount of 75% ethanol to the decoction pieces of Angelica dahurica, angelica, licorice, burnet, and Phellodendron five flavors according to the formula, decoct twice for 1 hour, combine the decoction liquid, filter, concentrate and dry into a dry extract;

[0062] 2. Add comfrey to 8 times the amount of 95% ethanol according to the formula, extract in a ...

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Abstract

The invention provides a tissue regeneration promoting and ulcer healing traditional Chinese medicine gel and a preparation method thereof, the tissue regeneration promoting and ulcer healing traditional Chinese medicine gel comprises 100-400 parts by weight of an active component and 200-400 parts by weight of a gel matrix, and the active component is prepared from the following raw materials in parts by weight: 10-50 parts of lithospermum, 10-50 parts of angelica dahurica, 30-100 parts of angelica sinensis, 30-100 parts of liquorice, 10-40 parts of dragon's blood, 10-50 parts of sanguisorba officinalis, 10-20 parts of borneol and 1-10 parts of golden cypress. According to the traditional Chinese medicine preparation, lithospermum, angelica dahurica, angelica sinensis, liquorice, dragon's blood, sanguisorba officinalis, borneol and golden cypress are adopted for compatibility, the effects of detoxifying, healing sore, nourishing and activating blood, removing slough and promoting granulation are achieved, the gel matrix is appropriate in fluidity, easy to spread, good in skin affinity and good in compatibility with a traditional Chinese medicine compound extracting solution, medicine can be slowly and stably released, and the curative effect is good. The bioavailability of the medicine is favorably improved. Through clinical verification, the tissue regeneration and ulcer healing traditional Chinese medicine gel has the effects of detoxifying, healing sore, nourishing blood, activating blood, removing slough and promoting tissue regeneration.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a traditional Chinese medicine gel for promoting regeneration and healing ulcers and a preparation method thereof. Background technique [0002] With the acceleration of population aging in my country, the number of patients with skin ulcers is increasing step by step. In addition to skin ulcers directly caused by burns, scalds, and mechanical trauma, they often appear as complications of diseases such as diabetes, arteriosclerosis, and cardiovascular and cerebrovascular diseases. Due to its high incidence rate, it is difficult to recover in a short period of time, which makes the process of disease treatment more difficult for patients. Chronic skin ulcer (CSU), also known as refractory ulcer, is a common and frequently-occurring disease in surgical clinics. It includes vascular ulcers, pressure ulcers, radiation ulcers and infectious ulcers. Studies in recent years have sho...

Claims

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Application Information

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IPC IPC(8): A61K9/06A61K36/889A61K36/896A61K47/32A61P17/02A61K31/045
CPCA61K9/06A61K9/0014A61K47/32A61K36/30A61K36/232A61K36/484A61K36/889A61K36/896A61K36/739A61K31/045A61K36/756A61P17/02A61K2236/333A61K2236/51A61K2236/39A61K2300/00Y02A50/30
Inventor 徐玲霞孙朋颜冬梅李斌王飞
Owner JIANGXI UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
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