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Titanium implant with nano bionic three-dimensional porous titanium trabecular structure as well as preparation method and application of titanium implant

A three-dimensional porous and trabecular structure technology, applied in nanotechnology, drug delivery, tissue regeneration, etc., can solve the problems of rare literature reports, complicated process and difficult operation of nano-scale bone-like trabeculae, and achieve high clinical application value, Strong operability and the effect of promoting osseointegration

Active Publication Date: 2022-03-11
THE SECOND AFFILIATED HOSPITAL OF ANHUI MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The trabecular bone structure is a loose porous grid structure well known to those skilled in the art. At present, a large number of studies have constructed a bone-like trabecular structure through 3D printing or laser sintering technology, which has been proved to be conducive to the adhesion, proliferation and differentiation of bone cells. However, these structures are almost all micron-scale structures, and there are few reports on the structure of nano-scale bone-like trabeculae
These methods require complex processes and expensive machine operations, and are difficult to operate on smaller or thinner metal materials

Method used

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  • Titanium implant with nano bionic three-dimensional porous titanium trabecular structure as well as preparation method and application of titanium implant
  • Titanium implant with nano bionic three-dimensional porous titanium trabecular structure as well as preparation method and application of titanium implant
  • Titanium implant with nano bionic three-dimensional porous titanium trabecular structure as well as preparation method and application of titanium implant

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preparation example Construction

[0030] As mentioned above, the present invention provides a method for preparing a titanium implant with a nano-bionic three-dimensional porous titanium trabecular structure, the method comprising:

[0031] In the presence of electrolyte, the titanium matrix M 0 Anodizing is carried out to obtain a titanium substrate M on which a titanium dioxide nanotube array layer is deposited 1 ;

[0032] Remove the titanium matrix M 1 Titanium dioxide nanotubes loaded on the top, to get the titanium matrix M loaded with nanobowl structure 2 ;

[0033] The titanium substrate M 2 Putting it in an alkaline solution for etching treatment can obtain the titanium implant with a nano biomimetic three-dimensional porous titanium trabecular structure.

[0034] In the technical solution provided by the invention, the anodic oxidation and alkali etching treatment technologies are creatively combined to build a uniform loose porous nano-scale bone-like trabecular structure on the titanium surfac...

Embodiment 1

[0048] This embodiment provides a method for preparing a titanium implant, comprising the following steps:

[0049] S1: Titanium substrate M 0 Preprocessing:

[0050] A high-purity titanium sheet with a thickness of 0.2mm (titanium substrate M 0 ) was cut into titanium discs with a diameter of 12mm, polished step by step with metallographic sandpaper from 800# to 7000#, then ultrasonically cleaned in propanol, ethanol and deionized water successively and dried;

[0051] S2: Anodizing treatment

[0052] Put the pretreated titanium disc into the ethylene glycol electrolyte of 88mol / L ammonium fluoride, use graphite as the cathode, connect the titanium disc to the anode, adjust the voltage to 60V, and carry out anodic oxidation at 25°C Treated for 2.5h to obtain the titanium matrix M 1 , for the convenience of description, the titanium matrix M 1 called S-NT;

[0053] Titanium substrate M 1 Placed in deionized water and ultrasonically oscillated to remove the titanium diox...

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Abstract

The invention relates to the technical field of biological implant materials, in particular to a titanium implant with a nanometer bionic three-dimensional porous titanium trabecula structure and a preparation method and application thereof.The method comprises the steps that in the presence of electrolyte, a titanium substrate M0 is subjected to anodic oxidation, and a titanium substrate M1 with a deposited titanium dioxide nanotube array layer is obtained; removing the titanium dioxide nanotube loaded on the titanium substrate M1 to obtain a titanium substrate M2 loaded with a nano bowl structure; the titanium matrix M2 is placed in an alkaline solution to be subjected to etching treatment, and the titanium implant with the nanometer bionic three-dimensional porous titanium trabecular structure is obtained. The titanium implant with the nano bionic three-dimensional porous titanium trabecula structure prepared on the basis of the method provided by the invention can promote adhesion, proliferation and differentiation capacities of rat bone marrow stromal stem cells in vitro and promote osseointegration of the titanium implant in vivo.

Description

technical field [0001] The invention relates to the technical field of biological implant materials, in particular to a titanium implant with a nano-bionic three-dimensional porous titanium trabecular structure and a preparation method and application thereof. Background technique [0002] Tooth loss has become a common disease that affects the physical and mental health of patients. Oral implants, as one of the most effective solutions for repairing oral dentition defects and loss of dentition, can restore the shape and function of the patient's oral and jaw system, and can significantly improve the patient's health. Quality of Life. Industrial pure titanium has become the material of choice for artificial implants because of its high metal performance, high corrosion resistance, excellent biocompatibility and osseointegration properties. [0003] However, there is usually no direct contact between the titanium implant and the bone, but a layer of fibrous tissue is formed,...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/06A61L27/56C25D11/26C23F1/38C23F17/00B82Y40/00
CPCA61L27/06A61L27/56C25D11/26C23F1/38C23F17/00B82Y40/00A61L2430/02A61L2400/18Y02P10/25
Inventor 孙磊张善勇
Owner THE SECOND AFFILIATED HOSPITAL OF ANHUI MEDICAL UNIV
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