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High-selectivity boric acid-doped metal organic framework magnetic adsorbent with core-shell structure as well as preparation method and application of high-selectivity boric acid-doped metal organic framework magnetic adsorbent

A metal-organic framework and magnetic adsorbent technology, applied in the field of analysis, can solve the problems of cumbersome enrichment operation, complicated preparation process, reduce non-specific adsorption, etc., achieve high enrichment capacity, simple operation steps, and reduce non-specific adsorption. Effect

Pending Publication Date: 2022-03-11
WUHAN INSTITUTE OF TECHNOLOGY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The preparation process of these boron-affinity materials is complicated, the enrichment operation is cumbersome, and usually accompanied by non-specific adsorption. Therefore, the design and preparation of hydrophilic boron-affinity magnetic materials can reduce non-specific adsorption and allow efficient and selective enrichment, separation and analysis of cis-II. Alcohol molecules are very necessary

Method used

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  • High-selectivity boric acid-doped metal organic framework magnetic adsorbent with core-shell structure as well as preparation method and application of high-selectivity boric acid-doped metal organic framework magnetic adsorbent
  • High-selectivity boric acid-doped metal organic framework magnetic adsorbent with core-shell structure as well as preparation method and application of high-selectivity boric acid-doped metal organic framework magnetic adsorbent
  • High-selectivity boric acid-doped metal organic framework magnetic adsorbent with core-shell structure as well as preparation method and application of high-selectivity boric acid-doped metal organic framework magnetic adsorbent

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Embodiment 1

[0053] This embodiment provides a method for preparing a metal-organic framework magnetic adsorbent doped with core-shell structure boric acid, comprising the following steps:

[0054] The first step: first use the hydrothermal method to synthesize Fe 3 o 4 Magnetic nanospheres: weigh 0.5g poly(4-styrenesulfonic acid-co-maleic acid) sodium salt (PSSMA, molar ratio 3:1) and dissolve it in 20mL ethylene glycol under magnetic stirring, then add 0.54g FeCl 3 Dissolve 6H2O to obtain an orange-yellow clear solution, then add 1.5g of anhydrous sodium acetate, stir evenly, transfer the above solution to the reaction kettle, put it in an oven at 200°C for 10 hours, after the reaction is completed, cool to room temperature, and use a magnet The magnetic nanospheres were collected, washed several times with water and ethanol, and dried under vacuum to obtain brown Fe 3 o 4 magnetic nanospheres.

[0055] The second step: use polydopamine to modify magnetic nanospheres: prepare 120mL d...

Embodiment 2

[0061] This embodiment provides a method for preparing a metal-organic framework magnetic adsorbent doped with core-shell structure boric acid, comprising the following steps:

[0062] The first step: first use the hydrothermal method to synthesize Fe 3 o 4 Magnetic nanospheres: Weigh 0.1g poly(4-styrenesulfonic acid-co-maleic acid) sodium salt (PSSMA, molar ratio 3:1) and dissolve it in 20mL diethylene glycol under magnetic stirring, then add 0.27g FeCl 3Dissolve 6H2O to obtain an orange-yellow clear solution, then add 1.5g of anhydrous sodium acetate, stir evenly, transfer the above solution to the reaction kettle, put it in an oven at 180°C for 20 hours, after the reaction is completed, cool to room temperature, and use a magnet The magnetic nanospheres were collected, washed several times with water and ethanol, and dried under vacuum to obtain brown Fe 3 o 4 magnetic nanospheres.

[0063] The second step: use polydopamine to modify magnetic nanospheres: prepare 120mL...

Embodiment 3

[0066] This embodiment provides a method for preparing a metal-organic framework magnetic adsorbent doped with core-shell structure boric acid, comprising the following steps:

[0067] The first step: first use the hydrothermal method to synthesize Fe 3 o 4 Magnetic nanospheres: Weigh 0.3g of poly(4-styrenesulfonic acid-co-maleic acid) sodium salt (PSSMA, molar ratio 3:1) and dissolve it in 20mL of ethylene glycol and diethylene glycol under magnetic stirring In the mixed solvent, add 1.08g FeCl 3 Dissolve 6H2O to obtain an orange-yellow clear solution, then add 1.5g of anhydrous sodium acetate, stir evenly, transfer the above solution to the reaction kettle, put it in an oven at 190°C for 5 hours, after the reaction is completed, cool to room temperature, and use a magnet The magnetic nanospheres were collected, washed several times with water and ethanol, and dried under vacuum to obtain brown Fe 3 o 4 magnetic nanospheres.

[0068] The second step: use polydopamine to ...

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Abstract

The invention relates to a high-selectivity core-shell structure boric acid doped metal organic framework magnetic adsorbent as well as a preparation method and application thereof, and the preparation method comprises the following steps: adding Fe3O4 magnetic nanospheres into a Tris-aqueous solution of alkalescent dopamine, and carrying out self-polymerization reaction to obtain polydopamine functionalized magnetic nanospheres Fe3O4 (at) PD; according to the preparation method, m-tetra (4-carboxyphenyl) porphyrin and 1, 4-p-phenylenediboronic acid are taken as double ligands, Fe3O4 (at) PD is taken as a core, a metal source and a solvent are added, and the boric acid doped metal organic framework magnetic adsorbent Fe3O4 (at) PD (at) BA-Zr-MOF with the core-shell structure is prepared. The prepared Fe3O4 (at) PD (at) BA-Zr-MOF has an obvious core-shell structure, is uniform in size and large in specific surface area, has better selectivity on nucleoside enrichment and is high in enrichment capacity.

Description

technical field [0001] The invention belongs to the technical field of analysis, and in particular relates to a highly selective core-shell structure boric acid-doped metal-organic framework magnetic adsorbent and a preparation method and application thereof. Background technique [0002] Biomolecules containing cis-diol structures such as glycoproteins, carbohydrates, neurotransmitters and nucleosides have important physiological functions and pharmacological activities. These biomolecules are often used as biomarkers for cancer, diabetes, neuroendocrine disorders, and cardiovascular diseases. For example, nucleosides in urine have been identified as potential biomarkers for cancers, including breast, lung, and cervical cancers, among others. Due to the complex sample matrix and low content of these biomolecules, proper sample pretreatment is a key step to remove interferences and selectively enrich cis-diol-containing biomolecules before direct instrumental analysis. [...

Claims

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Application Information

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IPC IPC(8): B01J20/26B01J20/28B01J20/30B01J20/22B01D15/08G01N30/02
CPCB01J20/262B01J20/06B01J20/226B01J20/28009B01D15/08G01N30/02B01J2220/4806B01J2220/4812
Inventor 张娟冯诗韬
Owner WUHAN INSTITUTE OF TECHNOLOGY
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