Preparation method of novel injectable drug-loaded hydrogel for treating osteosarcoma

A technology of osteosarcoma and gel, which is applied in the direction of antineoplastic drugs, pharmaceutical formulations, medical preparations of non-active ingredients, etc., can solve complex bone anatomy, disappointing pharmacokinetics and systemic toxicity, and difficult to remove bone tumors and other problems, to achieve good drug carrying capacity, long-lasting tumor treatment ability, and simple and convenient preparation and operation process

Pending Publication Date: 2022-04-29
JILIN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the complex anatomical structure of bone and the importance of neurovasculature, it is difficult to completely remove bone tumors during surgery
Additionally, the disappointing pharmacokinetics and systemic toxicity of chemotherapeutic agents is an issue that needs to be addressed

Method used

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  • Preparation method of novel injectable drug-loaded hydrogel for treating osteosarcoma
  • Preparation method of novel injectable drug-loaded hydrogel for treating osteosarcoma
  • Preparation method of novel injectable drug-loaded hydrogel for treating osteosarcoma

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Embodiment 1: The process of the embodiment is all in accordance with the above modified preparation process, only the specific data values ​​in each example are retained.

[0018] 1) Weigh 1.0g of sodium hyaluronate and add it to a container containing 100mL of deionized water, stir continuously and rapidly for half an hour until it is completely dissolved, then slowly add 4.0g of sodium periodate, and stir at room temperature for 5 hours in the dark. Then 3ml of ethylene glycol was added to stop the reaction, and a colorless transparent solution polymer solution was obtained. A dialysis bag with a molecular weight of 14,000 was used for dialysis in deionized water for 2 days, and the water was changed 4 times. After dialysis, the polymer solution was freeze-dried with a lyophilizer for 2 days to obtain a fluffy and porous solid material. It was formulated into 1.0 wt% aqueous solution A with deionized water for subsequent use.

[0019] 2) Add 1.0 g of chitosan to a t...

Embodiment 2

[0022] 1) Weigh 2.0g of sodium hyaluronate, add it to a container containing 150mL of deionized water, stir continuously and rapidly for half an hour until it is completely dissolved, then slowly add 6.0g of sodium periodate, and stir at room temperature for 5 hours in the dark. Then add 5ml of ethylene glycol to stop the reaction to obtain a colorless transparent polymer solution. A dialysis bag with a molecular weight of 14,000 was used for dialysis in deionized water for 3 days, and the water was changed 5 times. After dialysis, the polymer solution was freeze-dried by a lyophilizer for 2 days to obtain a fluffy and porous solid material. It was prepared into 1.0wt% aqueous solution C with deionized water for subsequent use.

[0023] 2) Add 1.5g of polylysine to a tank containing 200mL of deionized water, then add 1.5mL of acrylic acid, stir continuously at 55°C for 72 hours, adjust the pH of the system to 10 with sodium hydroxide at a concentration of 0.1mol / L , and then ...

Embodiment 3

[0026] 1) Add 1.0g of sodium hyaluronate to a container containing 100mL of deionized water, stir continuously and rapidly for half an hour until completely dissolved, then slowly add 4.0g of sodium periodate, and stir at room temperature for 5 hours in the dark. Then 3ml of ethylene glycol was added to stop the reaction, and a colorless transparent solution polymer solution was obtained. The dialysis bag with a molecular weight of 14000 was used for dialysis in deionized water for 2 days, and the water was changed 4 times. After dialysis, the polymer solution was lyophilized with a lyophilizer for 2 days to obtain a fluffy and porous solid material. It was prepared into 1.5wt% aqueous solution E with deionized water for subsequent use.

[0027] 2) Add 1.0 g of gelatin to a tank containing 200 mL of deionized water, then add 1.5 mL of acrylic acid, stir continuously at 60° C. for 72 hours, and adjust the pH of the system to 10 with 0.1 mol / L sodium hydroxide. Then add 0.12 mg...

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Abstract

The invention provides a preparation method of novel injectable drug-loaded hydrogel for treating osteosarcoma. Modified natural polymer sodium hyaluronate reacts with a high-molecular polymer containing amino and doxorubicin hydrochloride to prepare the injectable hydrogel, and the injectable hydrogel has good biocompatibility and degradability, can entrap a large amount of chemotherapeutic drug doxorubicin, can be slowly and slowly released in local responsiveness at the tumor site of osteosarcoma, and can be used for treating osteosarcoma. Therefore, the toxicity of the whole body is avoided. The injectable drug-loaded hydrogel material is a novel injectable drug-loaded hydrogel material for osteosarcoma treatment.

Description

technical field [0001] The invention belongs to the technical field of polymer materials, and in particular relates to a preparation method of a novel injectable drug-loaded hydrogel and its application in treating osteosarcoma. Background technique [0002] Osteosarcoma is the most common malignant tumor originating in bone tissue. It can occur inside the bone as well as on the surface of the bone. Its characteristic is that malignant tumor cells can directly generate tumor bone-like tissue, so it was also called osteogenic sarcoma clinically in the past. Osteosarcoma is the most common primary bone malignancy in children and young adults, with more men than women. About half of them occur in the distal femur and proximal tibia, followed by the upper end of the humerus, and others such as the spine and ribs can also occur. Despite major advances in the 1970s and 1980s, neither treatments nor outcomes have changed in decades. Osteosarcoma is a typical high-grade spindle-...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/06A61K47/61A61K47/64A61K31/704A61P35/00
CPCA61K9/06A61K9/0024A61K47/61A61K47/64A61K31/704A61P35/00
Inventor 林权李星辰杨喆王泽林杨柳杨柏
Owner JILIN UNIV
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