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Multifunctional titanium alloy coating and preparation method and application thereof

A titanium alloy, multi-functional technology, applied in the field of medical materials, can solve problems such as changes, implant failure, bone damage around the implant, etc., and achieve the effect of broad application prospects, strong practicability, and excellent antibacterial properties

Pending Publication Date: 2022-05-13
SHANGHAI FIRST PEOPLES HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

After bacterial invasion, the host will produce immune and inflammatory responses at the same time. Bacterial toxins and the host’s own defense response will lead to changes in the environmental conditions around the implant, which will lead to bone destruction around the implant and eventually implant failure. say catastrophic
In orthopedic joint surgery, the infection rate of total knee and hip replacement is 0.6%-16% and 0.5%-5%, respectively, and this problem has not been well solved
But about a kind of multifunctional titanium alloy coating of the present invention and its preparation method and application also do not see report at present

Method used

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  • Multifunctional titanium alloy coating and preparation method and application thereof
  • Multifunctional titanium alloy coating and preparation method and application thereof
  • Multifunctional titanium alloy coating and preparation method and application thereof

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Embodiment 1

[0030] The preparation method of embodiment 1 multifunctional antibacterial coating Ber&GO@Ti

[0031] The technical scheme adopted in the present invention is cathodic electrophoretic deposition technology. Graphene and berberine were deposited onto the surface of a titanium metal material.

[0032] The deposition solution is: add 0.5ml of graphene oxide aqueous dispersion (GO, 6mg / ml), 25mg of magnesium nitrate hexahydrate, 25mg of magnesium acetate tetrahydrate, 50mg of berberine hydrochloride into 250ml of absolute ethanol, and ultrasonicate for half an hour.

[0033] Acid-washed pure titanium (Ti) was used as the cathode, and graphite was used as the anode for cathodic electrophoretic deposition.

[0034] The deposition voltage is 40V, and the deposition time is 20s.

[0035] The positive progress effect of the present invention is: under the premise of no obvious cytotoxicity, the results of in vitro osteogenic activity evaluation show that compared with the Ti group, th...

Embodiment 2

[0045] Example 2 Animal experiment of multifunctional antibacterial coating Ber&GO@Ti

[0046] Animal experiments were carried out at the Shanghai Veterinary Research Institute of the Chinese Academy of Agricultural Sciences, and the laboratory approval number is SV-20210607-01. 6-week-old BALB / c mice were used to test the antibacterial effect of the samples in vivo. The operation is performed under sterile conditions. The mice were divided into four groups, 5 in each group (1) Ti (n=5): implant the sterile sample into the mice and suture the wound, 60ul Staphylococcus aureus suspension (10 7 CFU / mL) was subcutaneously injected around the sample, and the operations of the following groups were the same as above; (2) Ber@Ti (n=5); (3) GO@Ti (n=5); (4) Ber&GO@Ti (n=5 ). After 3 days, the animals were sacrificed, and infected skin tissues and specimens were collected, and the main organs included heart, liver, spleen, lung, and kidney. Organs were photographed. The samples we...

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Abstract

The invention discloses a multifunctional titanium alloy coating and a preparation method and application thereof. The preparation method comprises the following steps: depositing graphene (GO) and berberine on the surface of a pure titanium metal sheet by adopting a cathode electrophoretic deposition technology to prepare a titanium alloy coating Beramp; gO (at) Ti has no obvious cytotoxicity, and an in-vitro osteogenesis activity evaluation result shows that compared with a Ti group, Beramp, GO (at) Ti and GO (at) Ti have no obvious cytotoxicity; and the preosteoblasts on the GO (at) Ti group show higher expression of osteogenesis-related genes. Meanwhile, bacterial proliferation and plate coating results show that Beramp; and the GO (at) Ti group has excellent antibacterial performance through the synergistic effect of GO and berberine. In-vitro experiments also show that the material has good antibacterial effect and biocompatibility, and shows huge potential in surgical implants.

Description

technical field [0001] The invention relates to the technical field of medical materials, in particular to a multifunctional titanium alloy coating and its preparation method and application. Background technique [0002] Artificial joint replacement is one of the important methods for the treatment of advanced osteoarthritis, and has achieved good short-term and long-term effects. However, periprosthetic osteolysis after artificial joint replacement is still a major problem for clinicians. During the long-term use of the artificial joint prosthesis, wear particles (such as titanium, polyethylene, ceramics, etc.) will be produced, and these wear particles will gather on the boundary membrane between the bone and the prosthesis, stimulating various tissues around the prosthesis. Inflammatory reaction leads to enhanced osteoclastosis and weakened bone, leading to an imbalance between bone resorption and osteogenesis, and aseptic loosening of artificial joints is inevitable. T...

Claims

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Application Information

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IPC IPC(8): C25D13/12C25D13/04C25D13/02A61L27/06A61L27/28A61L27/30A61L27/50A61L27/54
CPCC25D13/12C25D13/04C25D13/02A61L27/06A61L27/303A61L27/28A61L27/50A61L27/54A61L2300/404A61L2430/24A61L2300/606A61L2420/02A61L2420/04A61L2300/108A61L2300/204
Inventor 韩夏影宋滇文
Owner SHANGHAI FIRST PEOPLES HOSPITAL
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