Implant with bioactive coating and manufacturing method thereof

A manufacturing method and bioactive technology, applied in coatings, drug delivery, pharmaceutical formulations, etc., can solve problems such as poor bonding strength between coatings and substrates, increased tendency and degree, and reduced biological activity, so as to avoid peeling and cracking, Improve the compactness and maintain the effect of stable degradation

CN114558177AActive Publication Date: 2022-05-31DABO MEDICAL TECH CO LTD
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Publication Date
2022-05-31

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Abstract

According to the implant with the bioactive coating and the manufacturing method of the implant, firstly, a multi-level micro-nano-level hole structure is formed in the surface of the implant, so that the surface of a base body obtains unique morphological characteristics, effective nucleation and attachment sites are provided for later spraying of the bioactive glass coating, and the surface of the implant is coated with the bioactive glass coating; then preparing the discontinuous bioactive glass coating in a texturing manner, improving the compactness of the coating and the proportion of an amorphous phase through chemical conversion treatment, and finally covering the textured discontinuous bioactive glass coating with a carbonated hydroxyapatite layer. The implant with the bioactive coating provided by the invention not only can avoid cracking and stripping of the coating, but also can avoid ion poisoning and alkali poisoning in the initial stage of implantation, can maintain the biological activity and stable degradation of the bioactive glass coating after implantation, and is convenient to take out after fracture healing.
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Description

technical field

[0001] The invention relates to the technical field of medical equipment, in particular to an implant with a bioactive coating and a manufacturing method thereof. Background technique

[0002] Metal (such as stainless steel, titanium alloy, etc.) internal fixation systems have achieved great success in the treatment of fractures, and they are still the most widely used internal fixation materials due to their high strength, mature technology, low cost, and convenience. It changes shape to fit the contours of the bone and is easy to store. However, the rigid metal internal fixation has a significant defect, that is, the histocompatibility of the metal internal fixation is not good. The poor histocompatibility originates from the corrosion of metal implants, that is, the release of metal ions. The released metal ions will bring a series of adverse reactions, such as local inflammation and tissue necrosis.

[0003] Bioactive glass is a kind of material that ca...

Examples

Embodiment 1

[0065] The present invention provides an implant with a bioactive coating, comprising a metal implant and a bioactive coating formed on the surface of the metal implant, the bioactive coating comprising textured discontinuous bioactive Glass coating and carbonated hydroxyapatite layer overlying the textured discontinuous bioactive glass coating.

[0066] refer to figure 1 , take the metal implant as the locking plate as an example, the locking plate 1 has a bioactive coating 2 on the surface of one side that fits the bone tissue, and the bioactive coating 2 includes textured discontinuous bioactive glass Coating 21 and carbonated hydroxyapatite layer 22 overlying the textured discontinuous bioactive glass coating.

[0067] The textured discontinuous bioactive glass coating here refers to that the textured bioactive glass coating is arranged on the surface of the metal implant in a discontinuous manner, that is, the bioactive glass coating has multiple bioactive glass coatings...

Embodiment 2

[0080] The present invention also provides a method for preparing the implant with the bioactive coating provided in Example 1, comprising the following steps:

[0081] S1. Sandblasting and acid etching treatment: the metal implant is subjected to acid washing treatment, and then the clean metal implant is subjected to multi-level micro-nano treatment to form a multi-level micro-nano level on the surface of the clean metal implant. hole structure.

[0082] The metal implants were cleaned before sandblasting and acid etching. The metal implants were first cleaned with acetone and deionized water, and then cleaned in H 3 PO 4 , HNO 3 , HF mixed acid solution soaked for 10min, then washed with deionized water and absolute ethanol respectively, dried in a 50 ℃ oven for use.

[0083] The multi-level micro-nano-scale hole structure on the surface of the metal implant is realized by sandblasting and acid etching in sequence. Among them, the sandblasting treatment can use ceramic ...