Implant with bioactive coating and manufacturing method thereof

Abstract

According to the implant with the bioactive coating and the manufacturing method of the implant, firstly, a multi-level micro-nano-level hole structure is formed in the surface of the implant, so that the surface of a base body obtains unique morphological characteristics, effective nucleation and attachment sites are provided for later spraying of the bioactive glass coating, and the surface of the implant is coated with the bioactive glass coating; then preparing the discontinuous bioactive glass coating in a texturing manner, improving the compactness of the coating and the proportion of an amorphous phase through chemical conversion treatment, and finally covering the textured discontinuous bioactive glass coating with a carbonated hydroxyapatite layer. The implant with the bioactive coating provided by the invention not only can avoid cracking and stripping of the coating, but also can avoid ion poisoning and alkali poisoning in the initial stage of implantation, can maintain the biological activity and stable degradation of the bioactive glass coating after implantation, and is convenient to take out after fracture healing.

Description

technical field [0001] The invention relates to the technical field of medical equipment, in particular to an implant with a bioactive coating and a manufacturing method thereof. Background technique [0002] Metal (such as stainless steel, titanium alloy, etc.) internal fixation systems have achieved great success in the treatment of fractures, and they are still the most widely used internal fixation materials due to their high strength, mature technology, low cost, and convenience. It changes shape to fit the contours of the bone and is easy to store. However, the rigid metal internal fixation has a significant defect, that is, the histocompatibility of the metal internal fixation is not good. The poor histocompatibility originates from the corrosion of metal implants, that is, the release of metal ions. The released metal ions will bring a series of adverse reactions, such as local inflammation and tissue necrosis. [0003] Bioactive glass is a kind of material that ca...

AI Technical Summary

Problems solved by technology

[0004] However, when plasma spraying is used to prepare bioactive glass coatings on the surface of metal implants, due to the large difference between the thermal expansion coefficient of bioactive glass and the thermal expansion coefficient of the metal substrate of the implant, the difference in thermal expansion coefficient during the spraying process Will cause thermal stress, which in turn will lead to poor bond strength between the coating and the substrate, causing cracking and peeling of the coating

By introducing K in the quaternary composition of the bioactive glass 2 O or MgO to replace part of Na 2 O, the matching between the thermal expansion coefficient of the bioactive glass and the metal substrate of the implant can be achieved, thereby forming a bioactive glass coating with optimized interfacial adhesion on the surface of the metal substrate of the implant, but K 2 The introduction of O or MgO not only optimizes the bonding strength between the coating and the substrate, but also increases the tendency and degree of the transition of the bioactive glass to the crystalline phase, thereby reducing its biological activity.

[0005] In addition, since the bioactive glass coating can bond with bone tissue and connect with soft tissue at the same time, the metal internal fixation device coated with continuous bioactive glass coating will grow with the bone growth after implanted in the fracture site. The entire internal fixation will gradually form a stable fixed combination with the bone and soft tissue, which will bring certain challenges to the removal of the internal fixation after the fracture has healed.

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