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Strontium-doped silicon dioxide nanofiber membrane and preparation method thereof

A nanofiber membrane, silica technology, applied in the chemical characteristics of fibers, rayon manufacturing, textiles and papermaking, etc., can solve problems such as affecting the effect of bone repair, improve bone repair effect, maintain biological activity, and have a wide range of raw materials. Effect

Pending Publication Date: 2022-06-07
诺一迈尔(苏州)生命科技有限公司 +1
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The problem solved by the present invention is that in the existing bone repair materials, strontium is prone to sudden release, which affects the bone repair effect

Method used

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  • Strontium-doped silicon dioxide nanofiber membrane and preparation method thereof
  • Strontium-doped silicon dioxide nanofiber membrane and preparation method thereof
  • Strontium-doped silicon dioxide nanofiber membrane and preparation method thereof

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preparation example Construction

[0027] In order to solve the problem that strontium is prone to sudden release and affects the effect of bone repair in the existing bone repair materials, the present invention provides a strontium-doped silica nanofiber membrane and a preparation method thereof. The preparation method includes the following steps:

[0028] S1: Mix ethyl orthosilicate, deionized water, and phosphoric acid to obtain SiO 2 Sol solution;

[0029] S2: towards SiO 2 The sol solution is added with strontium nitrate and stirred at room temperature to obtain a mixed sol solution;

[0030] S3: prepare an aqueous solution of polyvinyl alcohol;

[0031] S4: mixing the polyvinyl alcohol aqueous solution with the mixed sol solution to obtain an electrospinning solution;

[0032] S5: electrospinning the electrospinning solution to obtain a nanofiber membrane;

[0033] S6: calcining the nanofiber film to obtain a strontium-doped silica nanofiber film.

[0034] In the method for preparing a strontium-do...

Embodiment 1

[0041] S1: Mix ethyl orthosilicate, deionized water and phosphoric acid in a molar ratio of 1:11:0.01, and stir for 30h to obtain SiO 2 Sol solution;

[0042] S2: To 10g of SiO 2 Add 10 mg of strontium nitrate to the sol solution, and stir at room temperature to obtain a mixed sol solution;

[0043] S3: Dissolve 2 g of polyvinyl alcohol (PVA) in 18 g of water, and stir for 12 h to obtain a 10% polyvinyl alcohol aqueous solution;

[0044] S4: mixing the polyvinyl alcohol aqueous solution with the mixed sol solution of equal quality to obtain an electrospinning solution;

[0045] S5: Add the electrospinning solution to the syringe, install the syringe on the propelling pump, connect the high voltage, set the electrospinning high voltage to 20kV, the propelling speed to be 2ml / h, the aluminum foil as the receiving device, and the receiving distance to be 20cm. Spinning to prepare nanofiber membrane;

[0046] S6: placing the nanofiber membrane in a muffle furnace, calcining at...

Embodiment 2

[0054] S1: Mix ethyl orthosilicate, deionized water, and phosphoric acid in a molar ratio of 1:11:0.01, and stir for 40 h to obtain SiO 2 Sol solution;

[0055] S2: To 10g of SiO 2 The sol solution was added with 20 mg of strontium nitrate and stirred at room temperature to obtain a mixed sol solution;

[0056] S3: Dissolve 2 g of polyvinyl alcohol (PVA) in 18 g of water, and stir for 12 h to obtain a 10% polyvinyl alcohol aqueous solution;

[0057] S4: mixing the polyvinyl alcohol aqueous solution with the mixed sol solution of equal quality to obtain an electrospinning solution;

[0058] S5: Add the electrospinning solution into the syringe, install the syringe on the propelling pump, connect the high voltage, set the electrospinning high voltage to 20kV, the propelling speed to 2ml / h, the aluminum foil as the receiving device, and the receiving distance to be 20cm. Spinning to prepare nanofiber membrane;

[0059] S6: placing the nanofiber membrane in a muffle furnace, c...

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Abstract

The invention provides a strontium-doped silicon dioxide nanofiber membrane and a preparation method thereof, and the preparation method comprises the following steps: mixing tetraethoxysilane, deionized water and phosphoric acid to obtain a SiO2 sol solution; adding strontium nitrate into the SiO2 sol solution to obtain a mixed sol solution; preparing a polyvinyl alcohol aqueous solution; mixing a polyvinyl alcohol aqueous solution with the mixed sol solution to obtain an electrostatic spinning solution; performing electrostatic spinning on the electrostatic spinning solution to obtain a nanofiber membrane; and calcining the nanofiber membrane to obtain the strontium-doped silicon dioxide nanofiber membrane. According to the preparation method of the strontium-doped silicon dioxide nanofiber membrane, the preparation process is simple, the raw material source is wide, the prepared strontium-doped silicon dioxide nanofiber membrane has good biocompatibility, meanwhile, the ion release speed is slow, sudden release of strontium is avoided, and the preparation method is suitable for industrial production. The strontium-doped silicon dioxide nanofiber membrane can keep biological activity for a long time, bone tissue regeneration is promoted, and the bone repair effect is improved.

Description

technical field [0001] The invention relates to the technical field of inorganic nanofibers, in particular to a strontium-doped silica nanofiber membrane and a preparation method thereof. Background technique [0002] Vascularized autologous bone grafting is currently the gold standard for the treatment of large bone defects caused by trauma, infection, tumor, or avascular osteonecrosis. However, the clinical application of autologous bone grafting is limited due to limited sources, risk of infection, and immune rejection. Therefore, vascularized bone tissue engineering is urgently needed as an important substitute for implant materials in clinical bone defect repair. [0003] Angiogenesis is one of the prerequisites for new bone formation and remodeling during bone repair. The formation of new blood vessels is essential for the exchange of oxygen, nutrients and metabolic waste during bone regeneration. Improved angiogenesis positively affects osteoblast maturation, calci...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): D04H1/4209D04H1/4309D04H1/728D01F6/50D01F1/10
CPCD04H1/4209D04H1/4309D04H1/728D01F6/50D01F1/10Y02E60/10
Inventor 莫秀梅刘明月崔洁
Owner 诺一迈尔(苏州)生命科技有限公司
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