Application of heptamethine indocyanine small molecules with N-alkyl side chains with different chain lengths in preparation of photosensitizer for treating tumors
An indocyanine and small molecule technology, applied in the field of biomedical engineering, can solve the problems of remote metastatic tumor immunotherapy research, unsatisfactory phototherapy effect, and practical application limitations without phototherapy to activate the body's systemic anti-tumor immune response. , to amplify the immunogenic death of tumor cells, inhibit tumor growth, and enhance the effect of phototherapy
Pending Publication Date: 2022-06-28
ARMY MEDICAL UNIV
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Abstract
The invention relates to application of heptamethine indocyanine small molecules with N-alkyl side chains with different chain lengths in preparation of a photosensitizer for treating tumors. According to the application, self anti-tumor immune response is activated through tumor phototherapy. The photosensitizer has a good tumor preferential accumulation characteristic, accurate phototherapy guided by near-infrared imaging and tumor in-situ induced anti-tumor immune response, does not need to additionally take immunotherapy drugs, and has a bright application prospect in tumor targeted immunotherapy.
Application Domain
Photodynamic therapyIn-vivo testing preparations +1
Technology Topic
Tumor targetPhotosens +11
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