Galanthamine hydrobromide cream and preparation method thereof

A technology of galantamine hydrobromide and ointment, applied in ointment delivery, pharmaceutical formula, aerosol delivery, etc., can solve problems such as poor drug compliance and difficulty swallowing, achieve high encapsulation rate and simple preparation process , Great skin permeability and stability effects

Pending Publication Date: 2022-07-01
LUNAN PHARMA GROUP CORPORATION
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] Galanthamine hydrobromide currently on the market at home and abroad is a non-cream preparation, and it is difficult for the elderly to swallow, so the drug compliance is poor

Method used

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  • Galanthamine hydrobromide cream and preparation method thereof
  • Galanthamine hydrobromide cream and preparation method thereof
  • Galanthamine hydrobromide cream and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] The preparation of embodiment 1 galantamine hydrobromide cream (1) preparation of galantamine hydrobromide liposome

[0039] 1. Experimental materials

[0040] 1.1 Reagents Galantamine hydrobromide (Zhejiang Yixin Pharmaceutical Co., Ltd.), lecithin (Beijing Aoxing Biotechnology Co., Ltd.), cholesterol (BR Shanghai Zhengxiang Institute of Chemical Reagents).

[0041] 1.2 Instruments RE-524 Rotary Evaporator (Shanghai Yarong Biochemical); KT-300Y Ultrasonic Drug Processor (Jining Zhongguan Ultrasonic Co., Ltd.); XSZ-109 Optical Microscope (Guangzhou Instrument Factory); 752C UV-Vis Spectrophotometer Meter (Shanghai Third Instrument Factory).

[0042] 2. Methods and Results

[0043] 2.1 Preparation (1) Preparation of phosphate buffer solution (pH 5.0) Take a certain amount of 0.2mol / L sodium dihydrogen phosphate solution, and adjust the pH value to 5.0 with sodium hydroxide test solution.

[0044] (2) Thin film-ultrasonic method (TFV) Weigh an appropriate amount of lec...

Embodiment 2

[0062] The preparation of embodiment 2 Galantamine hydrobromide cream

[0063] (1) Preparation of Galantamine Hydrobromide Liposomes

[0064] Lecithin 210mg cholesterol 70mg Galantamine hydrobromide 20mg

[0065] Preparation method: Thin film-ultrasonic method (TFV) Weigh the prescription amounts of lecithin, cholesterol and galantamine hydrobromide, add appropriate amount of ethanol to dissolve them, put them in a pear-shaped bottle, and rotate under reduced pressure to evaporate the lipids in the bottle. The inner wall is uniformly formed into a film, drained, and an appropriate amount of phosphate buffer (pH 5.0) is added, shaken to transfer the lipid film from the bottle wall into the water phase, fully swelled with water, sonicated for 10 minutes, and then adjusted to volume with phosphate buffer. 20ml is ready.

[0066] (2) Preparation of cream base

[0067]

[0068]

[0069] The preparation method is the same as in Example 1.

[0...

Embodiment 3

[0072] The preparation of embodiment 3 Galantamine hydrobromide cream

[0073] (1) Preparation of galantamine hydrobromide liposomes

[0074] Lecithin 390mg cholesterol 130mg Galantamine hydrobromide 45mg

[0075] The preparation method is the same as that of Example 2.

[0076] (2) Preparation of cream base

[0077] Glyceryl Monostearate 20g octadecanol 20g Propylene Glycol 10g methylparaben 0.2g Propylparaben 0.1g Sodium dodecyl sulfate 0.5g

[0078] The preparation method is the same as in Example 1.

[0079] (3) Preparation of cream

[0080] The preparation method is the same as in Example 1.

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Abstract

The invention belongs to the technical field of pharmaceutical preparations, and particularly relates to a galanthamine hydrobromide cream and a preparation method thereof. By adopting the liposome as a carrier and encapsulating the galanthamine hydrobromide in the liposome, the drug can have higher skin permeability and stability, and the galanthamine hydrobromide has the same lipid as the cuticle and is easy to fuse with the cuticle, so that the effects of quick transdermal absorption, good curative effect, safety, no toxicity and no irritation are achieved; the preparation method is simple in preparation process, high in encapsulation efficiency, high in product yield, few in used raw materials and suitable for industrial production.

Description

technical field [0001] The invention belongs to the technical field of pharmaceutical preparations, in particular to a galantamine hydrobromide cream and a preparation method thereof. Background technique [0002] Galantamine hydrobromide (Galanthamine or Galantamine) is a phenanthridine alkaloid extracted from the bulbs of daffodils. It is a second-generation reversible and competitive cholinease inhibitor. Weak, but can selectively inhibit acetylcholinesterase, can strengthen the central nervous system cholinergic nerve impulse, can penetrate the blood-brain barrier, and has a long-lasting effect and low toxicity. [0003] Alzheimer's dementia (AD) is a disease with a higher incidence in the elderly, which is characterized by the gradual loss of cognitive functions (thinking, memory and reasoning), seriously affecting the daily life and work of patients, not only causing pain to patients, but also to the patient's family and family. Society brings great economic pressure ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/06A61K9/127A61K31/55A61K47/10A61K47/14A61K47/20A61K47/24A61K47/28A61P25/28
CPCA61K31/55A61K9/127A61K9/06A61K47/24A61K47/28A61K47/10A61K47/14A61K47/20A61P25/28
Inventor 鲁成浩王庆娟
Owner LUNAN PHARMA GROUP CORPORATION
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