Artificial bone material loaded with monatomic copper catalyst and application

A technology of copper catalyst and artificial bone, applied in additive processing, medical science, prosthesis, etc., can solve the problem of unsatisfactory treatment effect, and achieve the effects of promoting adhesion, high photothermal conversion rate, and good mechanical properties

Pending Publication Date: 2022-07-15
THE THIRD XIANGYA HOSPITAL OF CENT SOUTH UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the therapeutic effect of hypothermic PTT is often suboptimal due to the fact that tumor cells can activate their self-protection pathways, such as heat shock proteins (HSPs), to rapidly repair cellular damage caused by hypothermia.

Method used

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  • Artificial bone material loaded with monatomic copper catalyst and application
  • Artificial bone material loaded with monatomic copper catalyst and application
  • Artificial bone material loaded with monatomic copper catalyst and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0047] Example 1 (blank control group)

[0048] (1) Weigh 5g of L-polylactic acid (PLLA) powder with a molecular mass of 150,000 and disperse it in 50mL of anhydrous ethanol solution. The solution is uniformly mixed by magnetic stirring and ultrasonic dispersion. The magnetic stirring time is 10 minutes, and the magnetic stirring speed is 10 minutes. is 300r / min, the ultrasonic dispersion time is 30min, and the ultrasonic dispersion temperature is 50℃.

[0049] (2) After the mixed solution is filtered, it is dried in an electric blast drying oven. The main process parameters are: the drying temperature is 50°C, and the holding time is 24h.

[0050] (3) Put the mixed powder in the laser rapid prototyping system, and sinter layer by layer according to the three-dimensional model. After the sintering is completed, use compressed air to remove the unsintered powder to form the three-dimensional body of the artificial bone required. The main process parameters are: laser The power...

Embodiment 2

[0053] Compared with Example 1, the main difference lies in the addition of bioactive glass (BG) powder, which accounts for 10% of the mass of the composite powder. The specific operations are as follows:

[0054] (1) Weigh 4.5g of PLLA powder with a molecular mass of 150,000 and disperse it in 50mL of anhydrous ethanol solution. The solution is uniformly dispersed and mixed by magnetic stirring and ultrasonic waves. The magnetic stirring time is 10min, and the magnetic stirring speed is 300r / min. , the ultrasonic dispersion time was 30 min, and the ultrasonic dispersion temperature was 50 °C.

[0055] (2) Weigh 0.5g of BG powder, then add the BG powder into the beaker containing the PLLA solution, and the mixed solution is uniformly mixed by magnetic stirring and ultrasonic dispersion technology;

[0056] (3) After the mixed solution is filtered, it is dried in an electric blast drying oven. The main process parameters are: the drying temperature is 50°C, and the holding time...

Embodiment 3

[0060] Compared with Example 1, the main difference is that BG powder is added, which accounts for 10% of the mass ratio of the composite powder, and single-atom copper catalyst (SA-Cu-MXene) powder is added, which accounts for 0.25% of the mass ratio of the composite powder. The specific operation as follows:

[0061] (1) Weigh 4.4875g of PLLA powder with a molecular mass of 150,000 and disperse it in 50mL of anhydrous ethanol solution. The solution is uniformly mixed by magnetic stirring and ultrasonic dispersion. The magnetic stirring time is 10min, and the magnetic stirring speed is 300r / min. , the ultrasonic dispersion time was 30 min, and the ultrasonic dispersion temperature was 50 °C.

[0062] (2) Weigh 0.5g of BG powder, then add the BG powder into the beaker containing the PLLA solution, and the mixed solution is uniformly mixed by magnetic stirring and ultrasonic dispersion technology;

[0063](3) Weigh 0.0125g of powder, add SA-Cu-MXene powder into another beaker ...

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Abstract

The invention discloses an artificial bone material loaded with a monatomic copper catalyst and application. The artificial bone material loaded with the monatomic copper catalyst is prepared from L-polylactic acid powder, bioactive glass powder and SA-Cu-MXene powder. In the artificial bone material loaded with the monatomic copper catalyst, the mass percent contents of the L-polylactic acid powder, the bioactive glass powder and the SA-Cu-MXene powder are respectively 89.25 to 89.75 percent, 10.0 percent and 0.25 to 0.75 percent. SA-Cu-MXene in all the components of the composite scaffold can convert light energy into heat energy, and the mild photothermal effect is achieved; secondly, tumor cells can be efficiently induced to generate ferroptosis in a tumor microenvironment, the BG and the PLLA cooperate with each other to resist tumor treatment, and the BG and the PLLA have excellent biocompatibility and biological activity, so that the artificial bone material prepared by compounding the PLLA powder, the BG powder and the SA-Cu-MXene powder through additive manufacturing can be used for preparing the artificial bone material. The biological effect can be achieved by inhibiting postoperative local relapse and metastasis of bone tumors and repairing bone defects.

Description

technical field [0001] The invention belongs to the field of biomedical materials, and relates to an artificial bone material loaded with a single-atom copper catalyst (SA-Cu-MXene) and its application. Background technique [0002] Osteosarcoma (OS) is a common primary malignant tumor that occurs in adolescents with high malignancy and high morbidity and mortality. The main clinical treatment for osteosarcoma is to take Surgical resection and comprehensive treatment of neoadjuvant chemotherapy, however, surgical resection of osteosarcoma will not only cause huge tumorous bone defects, but residual osteosarcoma cells will also lead to tumor recurrence. There are many types of bone repair materials currently used in bone defects, which can be roughly divided into traditional bone repair materials and modern bone repair materials. Traditional bone repair materials are easy to obtain, and the manufacturing difficulty and cost are relatively low. Among them, autologous bone is ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/18A61L27/10A61L27/12A61L27/56A61L27/54A61L27/50B22F10/28B33Y10/00B33Y70/10B33Y80/00
CPCA61L27/18A61L27/10A61L27/12A61L27/56A61L27/54A61L27/50B22F10/28B33Y10/00B33Y70/10B33Y80/00A61L2430/02A61L2300/416C08L67/04
Inventor 邓幼文鄢祖赟
Owner THE THIRD XIANGYA HOSPITAL OF CENT SOUTH UNIV
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