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Hydrophilic lubricating anticoagulant hydrogel film as well as preparation method and application thereof

A technology of anticoagulant water and gel, which is applied in anticoagulant treatment, transportation and packaging, and packaged food, etc. It can solve the problems of poor hydrophilicity and lubricity, achieve mild applicability, improve physiological functions, and simple preparation methods

Active Publication Date: 2022-07-15
SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In order to solve the above-mentioned technical problems, the purpose of the present invention is to provide a kind of hydrophilic lubricating anticoagulation hydrogel film and its preparation method, to solve the existing catheter material hydrophilic The problem of poor water lubricity

Method used

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  • Hydrophilic lubricating anticoagulant hydrogel film as well as preparation method and application thereof
  • Hydrophilic lubricating anticoagulant hydrogel film as well as preparation method and application thereof
  • Hydrophilic lubricating anticoagulant hydrogel film as well as preparation method and application thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0038] A kind of hydrophilic lubricating anticoagulation hydrogel film, its preparation method comprises the following steps in sequence:

[0039] (1) Put the PVC catheter material in the plasma chamber, add 100 μL of epoxy silane coupling agent, react for 70 s, then wash with ethanol and water in turn, and dry with nitrogen to obtain the epoxy group-modified catheter material ; Then immersed in 2g / L polyethyleneimine solution, reacted at 30℃ for 30min, and then washed the catheter material with deionized water;

[0040](2) Immerse the catheter material obtained in the step (1) into a solution of epigallocatechin gallate (EGCG) with a concentration of 2 g / L, react with a Schiff base at 30° C. for 15 min, and then use deionized water cleaning catheter material;

[0041] (3) adding sulfonic acid to the hyaluronic acid solution with a concentration of 0.6 g / L to obtain a mixed solution, activated for 30 min to obtain a sulfonated hyaluronic acid solution, the concentration of su...

Embodiment 2

[0044] A kind of hydrophilic lubricating anticoagulation hydrogel film, its preparation method comprises the following steps in sequence:

[0045] (1) Put the PVC catheter material in the plasma chamber, add 50 μL of epoxy silane coupling agent, react for 30 s, then wash with ethanol and water in turn, and dry with nitrogen to obtain the epoxy group-modified catheter material ; Then immersed in 0.5g / L polyethyleneimine solution, reacted at 20℃ for 60min, and then washed the catheter material with deionized water;

[0046] (2) immersing the catheter material obtained in step (1) into the epicatechin solution and the solution with a concentration of 0.1 g / L, at 20 ° C, the Schiff base is reacted for 20min, and then the catheter material is washed with deionized water;

[0047] (3) Add sulfonic acid to the hyaluronic acid solution with a concentration of 0.2 g / L to obtain a mixed solution, activate for 30 min to obtain a sulfonated hyaluronic acid solution, the concentration of s...

Embodiment 3

[0051] A kind of hydrophilic lubricating anticoagulation hydrogel film, its preparation method comprises the following steps in sequence:

[0052] (1) Put the PVC catheter material in the plasma chamber, add 200 μL of epoxy silane coupling agent, react for 120 s, then wash with ethanol and water in turn, and blow dry with nitrogen to obtain the epoxy group-modified catheter material ; Then immersed in 10g / L polyethyleneimine solution, reacted at 40°C for 10min, and then washed the catheter material with deionized water;

[0053] (2) Immerse the catheter material obtained in step (1) into an epicatechin gallate solution with a concentration of 10 g / L, react with a Schiff base at 40° C. for 5 min, and then wash the catheter material with deionized water ;

[0054] (3) Add sulfonic acid to the hyaluronic acid solution with a concentration of 1 g / L to obtain a mixed solution, activate for 30 min to obtain a sulfonated hyaluronic acid solution, the concentration of sulfonic acid i...

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Abstract

The invention discloses a hydrophilic lubricating anticoagulant hydrogel film and a preparation method and application thereof, and the preparation method comprises the following steps: modifying a catheter material with an epoxy group, then immersing in a polyethyleneimine solution, reacting at 20-40 DEG C for 10-60 minutes, and cleaning; then immersing into a tea polyphenol solution, reacting for 5-20 minutes under the condition of 20-40 DEG C, and cleaning; and finally, immersing into a sulfonated hyaluronic acid solution, reacting at 25-40 DEG C for 2-48 minutes, and cleaning to obtain the hydrophilic lubricating anticoagulant hydrogel film. According to the method, the biocompatibility of the catheter material can be remarkably improved, meanwhile, the catheter material has good hydrophilic, anti-pollution, anti-coagulation and anti-inflammatory functions, and the occurrence rate of adverse reactions after the catheter material enters a human body can be reduced.

Description

technical field [0001] The invention relates to the technical field of biomedical material preparation, in particular to a hydrophilic lubricating anticoagulation hydrogel film and a preparation method and application thereof. Background technique [0002] With the continuous development of modern medicine, medical catheters are widely used in the nursing of uterine planing, endocrine surgery, tumor cutting and other operations, and the clinical requirements for the type, quantity and performance of medical catheters are also increasing. Currently commonly used medical catheters (including urinary catheters, guide wires, balloon catheters, drainage catheters, central venous catheters, angiography catheters) are mostly made of hydrophobic materials, such as polyvinyl chloride, polyurethane, nylon, polyetheretherketone, silicon Polymer materials such as rubber bring convenience to the clinical diagnosis and treatment process, but also have some problems. Because they are hydro...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L29/08A61L29/14A61L29/16A61L33/00A61L33/08
CPCA61L29/085A61L29/08A61L29/16A61L29/14A61L33/0076A61L33/08A61L2300/216A61L2300/232A61L2300/42A61L2300/404C08L5/08C08L79/02
Inventor 张博王云兵
Owner SICHUAN UNIV
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