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Mg/Zn-MOF-74-coated Fe3O4 magnetic composite material and application thereof in aflatoxin enrichment

A magnetic composite material and aflatoxin technology, which is applied in the field of magnetic nanomaterials and food safety, can solve the problems of low adsorption efficiency, slow extraction speed, and high cost of use, and achieve the effect of less reagents, low cost, and high pretreatment efficiency

Active Publication Date: 2022-08-02
HUAZHONG AGRI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The purpose of the present invention is to solve the problems of low adsorption efficiency, slow extraction speed and high use cost of the existing food sample pretreatment method, and provides a Mg / Zn-MOF-74@Fe 3 o 4 Magnetic composite material and its application in the enrichment of aflatoxin, the material prepared by this method can efficiently and quickly enrich AFB in food 1

Method used

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  • Mg/Zn-MOF-74-coated Fe3O4 magnetic composite material and application thereof in aflatoxin enrichment
  • Mg/Zn-MOF-74-coated Fe3O4 magnetic composite material and application thereof in aflatoxin enrichment
  • Mg/Zn-MOF-74-coated Fe3O4 magnetic composite material and application thereof in aflatoxin enrichment

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0105] Example 1 A kind of preparation of Mg / Zn-MOF-74@Fe 3 O 4 Methods

[0106] (1) Fe 3 O 4 Preparation of Magnetic Nanoparticles

[0107] FeCl 3 ·6H 2 O (10.0 mmol) and NaAc (4.0 mmol) were added to 25 mL of ethylene glycol (50 mL beaker for easy stirring), followed by 3.0 mmol of SDS and magnetic stirring at 400 r / min for 15-30 min. The yellow transparent mixed solution was then transferred to a 50 mL synthesis vessel and heated at 220 °C for 10 h. After cooling to room temperature, Fe was separated by magnetic separation 3 O 4 The black precipitate was separated from the remaining solution, and the resulting Fe was subsequently washed repeatedly with deionized water and absolute ethanol. 3 O 4 Magnetic nanoparticles until the supernatant is neutral. Finally, the prepared magnetic nanoparticles were placed in a vacuum drying oven and vacuum-dried at 80 °C for 2.5 h to obtain Fe with superparamagnetic properties. 3 O 4 Magnetic nanoparticles were stored at 4°C ...

Embodiment 2

[0112] Example 2 Selection and Optimization of Synthetic Raw Materials

[0113] (1) Prepare Fe according to the step (1) of Example 1 3 O 4 magnetic nanoparticles;

[0114] (2) prepare Mg / Zn-MOF-74 by step (2) of embodiment 1;

[0115]Preparation of Mg-MOF-74: The pretreated titanium sheet was immersed in 1 mL of 0.1 mol / L Mg(NO) 3 ) 2 ·6H 2 O1h. After the reaction was completed, titanium flakes, 0.3 mmol DHTA and 5 mL DMF were added to a polytetrafluoroethylene reactor (microwave assisted heating), and heated at 130° C. for 24 h. The titanium sheet pretreatment method and the cleaning and drying method of Mg-MOF-74 are consistent with step (2) of Example 1.

[0116] Preparation of Zn-MOF-74: The pretreated titanium sheet, 0.3 mmol DHTA, 1 mmol Zn(NO 3 ) 2 ·6H 2 O and 15 mL of DMF were added to the Teflon reactor (microwave assisted heating) and heated at 130 °C for 24 h. The titanium sheet pretreatment method and the cleaning and drying method of Zn-MOF-74 are cons...

Embodiment 3

[0125] Example 3 Mg / Zn-MOF-74@Fe 3 O 4 Structural characterization of

[0126] Prepare Mg / Zn-MOF-74@Fe by the method of Example 1 3 O 4 .

[0127] (1) Characterization by scanning electron microscope (SEM)

[0128] image 3 for Fe 3 O 4 and Mg / Zn-MOF-74@Fe 3 O 4 scanning electron microscope image. like image 3 shown, Fe 3 O 4 The cross-linking and bonding between the nanoparticles and the Mg / Zn-MOF-74 metal framework formed a clear regular hexagonal cluster structure with a size of about 380-480 nm. The size of the regular hexagonal cluster structure in each region is different, which is presumed to be obvious crystal growth during the high-temperature synthesis process. The above electron microscope directly proves that Mg / Zn-MOF-74@Fe 3 O 4 Synthesis. This shows that Fe 3 O 4 The nanoparticles were successfully incorporated into the Mg / Zn-MOF-74 metal framework.

[0129] (2) Energy Dispersion (EDS) Characterization

[0130] Table 2 shows Mg / Zn-MOF-74@Fe ...

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Abstract

The invention discloses an Mg / Zn-MOF-74 (at) Fe3O4 magnetic composite material and an application of the Mg / Zn-MOF-74 (at) Fe3O4 magnetic composite material in enrichment of aflatoxin. According to the preparation method, the Fe3O4 magnetic nanoparticles with uniform particle size and relatively strong magnetic responsiveness are successfully prepared by adopting a hydrothermal method. Then synthesizing a hollow-structure organic framework material Mg / Zn-MOF-74 mixed with Mg / Zn metal by utilizing an ion exchange method, compounding amino on the surface of Fe3O4 with the Mg / Zn metal of the metal framework material by utilizing a layer-by-layer assembly method, and rapidly synthesizing Mg / Zn-MOF-74-coated Fe3O4 under the microwave-assisted action. Zn < 2 + > in the material and beta-dicarbonyl in an aflatoxin B1 structure can generate a stable chemical bonding effect, so that when the material is applied to magnetic solid-phase extraction, efficient adsorption of aflatoxin B1 in food can be realized, and the maximum adsorption capacity can reach 8.921 mg / g. Compared with the traditional pretreatment method, the prepared Mg / Zn-MOF-74-coated Fe3O4 has the advantages of high separation speed, high extraction efficiency, environment friendliness, low price and the like.

Description

technical field [0001] The invention belongs to the fields of food safety and magnetic nanomaterials, in particular to a Mg / Zn-MOF-74@Fe 3 O 4 Magnetic composites and their application in enrichment of aflatoxins. Background technique [0002] Food is the basis for human survival, and food safety is of great significance to people's health and the national economy. However, food is highly susceptible to fungal contamination during storage, transportation and sale, producing mycotoxins with strong teratogenic, carcinogenic and mutagenic properties. At present, more than hundreds of mycotoxins with different morphological structures have been discovered, among which aflatoxin B 1 (AFB 1 ) is a small molecule metabolite produced by Aspergillus flavus and Aspergillus parasiticus and is considered to be the strongest carcinogen discovered so far. However, AFB 1 Usually exists in food samples in trace or ultra-trace form, and there are a lot of starch, protein and fat in foo...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08L87/00C08K3/22C08G83/00B01D15/38B01D15/42H01F1/34
CPCC08K3/22C08G83/008B01D15/3885B01D15/424H01F1/344C08K2003/2275C08K2201/01C08K2201/011C08L87/00
Inventor 陈翊平黄伟杨宏李晓晗
Owner HUAZHONG AGRI UNIV
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