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Metal bone cement, porous metal microspheres and preparation method of porous metal microspheres

A porous metal and microsphere technology, applied in the field of bone defect repair, can solve problems such as poor mechanical properties, affecting the implantation effect of bone filling materials, poor stability, etc., achieve high precision, realize the integration of function and structure, and ensure stability. Effect

Active Publication Date: 2022-08-05
UNIV OF SCI & TECH BEIJING
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although ceramics and polymer materials have good biodegradability and bioactivity, their mechanical properties are poor
In addition, the existing bone particles are difficult to inject into bone defects through minimally invasive surgery, and the stability after implantation is poor, which affects the implantation effect of bone filling materials

Method used

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  • Metal bone cement, porous metal microspheres and preparation method of porous metal microspheres
  • Metal bone cement, porous metal microspheres and preparation method of porous metal microspheres
  • Metal bone cement, porous metal microspheres and preparation method of porous metal microspheres

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preparation example Construction

[0041] see Figure 4A , Figure 4A It is a schematic diagram of a preparation method according to an embodiment of the present invention. The forming method of porous metal microspheres of the present invention comprises the following steps:

[0042] Step S100, select a degradable metal powder material as required, the metal powder material is magnesium-based metal, zinc-based metal, iron-based metal or molybdenum-based metal, the degradable metal powder is preferably spherical powder, and the powder particle size is in the range of 15 -53μm;

[0043] Step S200, heating and drying the degradable metal powder material in a vacuum drying oven, the heating temperature is 60-150°C, and the drying time is 3-6 hours;

[0044] Step S300 , selecting an alloy with the same composition as the metal powder material as a substrate, and preheating the substrate, and the preheating temperature is 100-200° C.;

[0045] Step S400, designing a three-dimensional model of the porous metal mi...

Embodiment 1

[0053] see Figure 5 , Figure 5 It is the porous pure zinc microsphere of Example 1 of the present invention. In this example, degradable porous pure zinc microspheres with body-centered cubic cell structure were prepared.

[0054] Porous microspheres with an external dimension of 2 mm were designed using Magics software. The interior of the porous microspheres was a body-centered cubic beam-rod cell structure with a rod diameter of 0.3 mm. The porous microsphere model was saved in STL format.

[0055] Select aerosolized spherical pure zinc powder with a particle size distribution of 15-53μm. Put the powder into a vacuum drying oven, the heating temperature is 60°C, and the drying time is 4 hours.

[0056] A pure zinc substrate is selected, and the substrate is preheated at 200°C.

[0057] The porous microsphere STL model was imported into the layering software, supports were added, and sliced ​​at 30 μm per layer.

[0058] Set the laser powder bed fusion printing parame...

Embodiment 2

[0063] see Image 6 , Image 6 It is the porous zinc-magnesium alloy microsphere polyhedron of Example 2 of the present invention. In this example, a degradable porous zinc-magnesium alloy tetrahedron with a diamond cell structure was prepared.

[0064] Magics software was used to design a porous cube with an external dimension of 2 mm. The interior of the porous cube was a diamond beam-rod cell structure with a rod diameter of 0.4 mm. The porous microsphere model was saved in STL format.

[0065] The gas-atomized spherical Zn-3Mg alloy powder is selected, and the particle size distribution of the powder is 15-53 μm. Put the powder into a vacuum drying oven, the heating temperature is 60°C, and the drying time is 4 hours.

[0066] A zinc-magnesium alloy substrate is selected, and the substrate is preheated at 200°C.

[0067] The porous microsphere STL model was imported into the layering software, supports were added, and sliced ​​at 30 μm per layer.

[0068] Set the lase...

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Abstract

The invention relates to metal bone cement, porous metal microspheres and a preparation method thereof, the metal bone cement is used for bone defect repair, the metal bone cement is prepared by mixing the porous metal microspheres and hydrogel, the volume ratio of the porous metal microspheres to the hydrogel is 0.1-2, the porosity of the metal bone cement is 50-90%, and the metal bone cement is degradable and injectable; the shape of the porous metal microsphere is a regular or irregular sphere, the interior of the porous metal microsphere is of an internally-communicated porous cell structure, the irregular sphere comprises an ellipsoid and a polyhedron structure, and the porous cell structure comprises a beam-column cell structure and a surface cell structure. The invention also provides a preparation method of the porous metal microsphere. The porous metal microspheres are fine in structure, free of cracks, good in fluidity and good in biocompatibility and can promote adhesion, proliferation or differentiation of osteoblasts in the porous metal microspheres, the injectability of the porous metal microspheres is achieved through the metal bone cement, and the mechanical property and stability of the bone filling material are improved.

Description

technical field [0001] The invention relates to bone defect repair technology, in particular to a porous degradable and injectable metal bone cement and porous metal microspheres for repairing bone defects and a preparation method thereof. Background technique [0002] Bone defect caused by bone trauma and bone disease is a common clinical disease. Large-scale bone defects usually cannot heal by themselves, which is one of the biggest clinical challenges in orthopaedics. Treatment of large bone defects usually includes autologous bone grafting and allogeneic bone grafting. However, allogeneic bone grafting carries the risk of disease transmission, and autologous bone grafting as the gold standard also has the limitations of limited supply, multiple surgeries, and inability to match the anatomical model of the bone defect. Therefore, artificial bone filling materials came into being. At present, the commonly used artificial bone filling materials are bioceramics or degradab...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B22F1/0655B22F10/28B22F10/62B33Y80/00
CPCB22F10/28B22F10/62B33Y80/00Y02P10/25
Inventor 李亚庚王鲁宁王磊
Owner UNIV OF SCI & TECH BEIJING
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