Green synthesis method of 4-pyridine sulfonic acid

Abstract

The invention discloses a green synthesis method of 4-pyridine sulfonic acid, which comprises the following steps: by taking 4-chloropyridine as a raw material, hydrogen peroxide as an oxidant and water as a reaction solvent, carrying out oxidation reaction under the catalytic action of a titanium silicalite molecular sieve to generate 4-chloropyridine nitrogen oxide; the method comprises the following steps: by taking water as a reaction solvent, reacting 4-chloropyridine nitrogen oxide with sulfinate to obtain 4-sulfonate pyridine nitrogen oxide; under the catalytic action of a metal catalyst, the 4-pyridine sulfonate oxynitride and hydrogen are subjected to a reduction reaction to obtain 4-pyridine sulfonate, after the reaction is finished, the pH of a reaction solution is adjusted to be neutral, filtering and drying are conducted, and 4-pyridine sulfonate is obtained. 4-chloropyridine is taken as a starting raw material, the raw material is simple and easy to obtain, a product of each step of reaction does not need to be separated and is directly used as a raw material of the next step of reaction, use of a large amount of strong acid and strong alkali is avoided, a large amount of waste water and waste residues cannot be generated, pollution is basically avoided, and the development requirement of green chemistry is met.

Description

technical field [0001] The invention belongs to the fields of chemical industry and medicine, and relates to a green synthesis method of 4-pyridinesulfonic acid. Background technique [0002] 4-Pyridinesulfonic acid is widely used and can be used as organic synthesis intermediates and raw materials, such as intermediates for sulfonamide and other drugs, and 4-hydroxypyridine can also be prepared; 4-pyridinesulfonic acid is also used as water-soluble Reactive dyes; 4-pyridine sulfonic acid can also be applied to the field of electrochemistry, which has the effect of improving the precipitation performance of the electrodeposition bath during the electroplating process. 4-Pyridinesulfonic acid is an irritant substance that is irritating to the eyes, respiratory system and skin. [0003] The synthesis of 4-pyridinesulfonic acid mainly includes the following methods: [0004] (1) Using 4-mercaptopyridine as a raw material, in a hydrogen peroxide and acetic acid system, the rea...

AI Technical Summary

Problems solved by technology

The raw material conversion rate and yield of this method are all low, and 4-mercaptopyridine is not easy to obtain, and the pungent taste is bigger;

[0005] (2), using bispyridinethione as a raw material, in a hydrogen peroxide and acetic acid system, react to obtain 4-pyridine sulfonate, with a yield of 49%, but bispyridinethione is not easy to obtain and difficult to prepare;