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Injectable light-cured sodium alginate hydrogel and application thereof

A technology of sodium alginate and hydrogel, which is applied in the direction of prosthesis, medical science, etc., can solve the problems of insufficient mild cross-linking mode, poor mechanical properties and stability of hydrogel, and achieve good operability and strong stability. , the effect of low toxicity biocompatibility

Pending Publication Date: 2022-08-05
NANJING UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The present invention aims at the problems that the existing hydrogel cross-linking method is not mild enough, and the mechanical properties and stability are poor, and provides an injectable photocurable sodium alginate hydrogel and its application

Method used

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  • Injectable light-cured sodium alginate hydrogel and application thereof
  • Injectable light-cured sodium alginate hydrogel and application thereof
  • Injectable light-cured sodium alginate hydrogel and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] (1) Dissolve 1 g of sodium alginate in 100 mL of deionized water, use a magnetic stirrer to stir until completely dissolved to obtain a 1% (w / v) sodium alginate solution; add 1 mol / L of hydroxide to the sodium alginate solution Sodium, adjust the pH of the solution to 10.0; then add glycidyl methacrylate dropwise to the sodium alginate solution to ensure that the molar ratio of sodium alginate to glycidyl methacrylate is 1:3; place the solution at 60°C In a magnetic stirring water bath, under nitrogen protection, the reaction was stirred for 8h. After the reaction, use an 8kDa dialysis bag to thoroughly dialysis in deionized water for 72h at room temperature for purification, and freeze-dry using a freeze dryer to obtain Alg-GMA, which is ready for use.

[0034] (2) Completely dissolving 0.01 g of Alg-GMA in 1 mL of deionized water containing 0.5% (w / v) photoinitiator I2959 to obtain a 1% (w / v) Alg-GMA precursor solution; then adding 0.005 g of silicic acid Magnesium-l...

Embodiment 2

[0038] (1) Dissolve 1 g of sodium alginate in 100 mL of deionized water, use a magnetic stirrer to stir until completely dissolved to obtain a 1% (w / v) sodium alginate solution; add 1 mol / L of hydroxide to the sodium alginate solution Sodium, adjust the pH of the solution to 10.5; then add glycidyl methacrylate dropwise to the sodium alginate solution to ensure that the molar ratio of sodium alginate to glycidyl methacrylate is 1:2; place the solution at 60°C In a magnetic stirring water bath, under nitrogen protection, the reaction was stirred for 8h. After the reaction, use an 8kDa dialysis bag to thoroughly dialysis in deionized water for 72h at room temperature for purification, and freeze-dry using a freeze dryer to obtain Alg-GMA, which is ready for use.

[0039] (2) 0.02g Alg-GMA was completely dissolved in 1mL deionized water containing 1% (w / v) photoinitiator I2959 to obtain 2% (w / v) Alg-GMA precursor solution; then 0.01g silicic acid was added Magnesium-lithium, ult...

Embodiment 3

[0043](1) Dissolve 1 g of sodium alginate in 100 mL of deionized water, use a magnetic stirrer to stir until completely dissolved to obtain a 1% (w / v) sodium alginate solution; add 1 mol / L of hydroxide to the sodium alginate solution Sodium, adjust the pH of the solution to 10.5; then add glycidyl methacrylate dropwise to the sodium alginate solution to ensure that the molar ratio of sodium alginate to glycidyl methacrylate is 1:1; place the solution at 60°C In a magnetic stirring water bath, under nitrogen protection, the reaction was stirred for 6 h. After the reaction, use an 8kDa dialysis bag to thoroughly dialysis in deionized water for 72h at room temperature for purification, and freeze-dry using a freeze dryer to obtain Alg-GMA, which is ready for use.

[0044] (2) 0.02g Alg-GMA was completely dissolved in 1mL deionized water containing 0.5% (w / v) photoinitiator I2959 to obtain 2% (w / v) Alg-GMA precursor solution; then 0.005g silicic acid was added Magnesium-lithium, ...

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Abstract

The invention belongs to the field of biomedical polymer materials and medical instruments, and particularly relates to injectable light-cured sodium alginate hydrogel and application thereof. The preparation method comprises the following steps: grafting glycidyl methacrylate to a macromolecular chain segment of sodium alginate in a ring opening manner, and introducing a double-bond group to obtain the photocurable modified sodium alginate polymer. By introducing magnesium lithium silicate, magnesium ions released by the magnesium lithium silicate are crosslinked with the modified sodium alginate polymer to form pregel, and the pregel can be injected to a wound part and is highly attached to the shape of the wound; and under the irradiation of ultraviolet light, free radicals are induced to polymerize in situ to form a second layer of hydrogel network, so that the mechanical property of the hydrogel network is further enhanced. By adjusting the solid content of the polymer and the concentration of the magnesium lithium silicate, the swelling degradation performance, the compression resistance and other mechanical properties of the tissue engineering scaffold can be remarkably regulated and controlled. The sodium alginate hydrogel is easy to operate, low in cost and easy to obtain, has the characteristics of mild reaction conditions, high stability, good mechanical properties, excellent biocompatibility and the like, and can be widely applied to the fields of medical dressings, 3D printing and tissue engineering.

Description

technical field [0001] The invention belongs to the field of biomedical polymer materials and medical equipment, and particularly relates to an injectable photocurable sodium alginate hydrogel and its application. Background technique [0002] As a three-dimensional network scaffold material with high water content, hydrogel can maintain the moist environment of wounds, absorb wound exudate, and at the same time have a high similarity with the natural extracellular matrix, which can provide adhesion and adhesion of fibroblasts and keratinocytes. Migration provides additional support, further helping to regenerate new tissue. Injectable hydrogels are widely used in the field of tissue engineering due to their advantages of minimally invasive injection operation and high matching of any defect shape. [0003] The mechanical properties of hydrogels play important roles in regulating cell-matrix interactions and regulating various biological processes such as cell proliferation...

Claims

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Application Information

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IPC IPC(8): C08J3/075C08L5/04C08B37/04A61L27/02A61L27/20A61L27/50A61L27/52A61L27/54
CPCC08J3/075C08B37/0084A61L27/52A61L27/20A61L27/54A61L27/025A61L27/507C08J2305/04A61L2400/06A61L2300/102A61L2300/418A61L2300/404A61L2300/412C08L5/04
Inventor 迟波祁靖杰余定华张文杰王鹏辉
Owner NANJING UNIV OF TECH
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