Synthesis of geranyl geraniol

A technology of geranylgeraniol and its synthesis method, which is applied in chemical instruments and methods, preparation of hydroxyl compounds, preparation of organic compounds, etc., and can solve problems such as lack of practical application value
CN1218918CInactive Publication Date: 2005-09-14ZHEJIANG UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
ZHEJIANG UNIV
Publication Date
2005-09-14
Estimated Expiration
Not applicable · inactive patent

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Abstract

A process for synthesizing geranylgeraniol includes such steps as selectively oxidizing (E)-methyl of geranyl acetate by SeO2-tert-butyl hydrogen peroxide in dichloromethane to obtain mixed oxide, reducting by sodium borohydride in emthanol to obtain 8-geranyl hydroxy acetate, reacting on phosphorus tribromide in anhydrous ether under existance of pyridine to obtain trans-8-geranyl bromoacetate, condensation reacting on geranyl sulfone in N,N-dimethyl methylamide under existance of tert-butanol potassium to obtain 9-sulfogeranyl geraniol, and reducting by lithium in methylamine.
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Description

technical field

[0001] The invention relates to a method for synthesizing geranylgeraniol. Background technique

[0002] Geranyl geraniol (all-trans-Geranylgeraniol, 3, 7, 11, 15-tetramethylhexadeca-2E, 6E, 10E, 14-tetraenol) is a straight-chain diterpenoid, and its molecular structure is:

[0003]

[0004] Geranylgeraniol itself has a wide range of physiological activities, such as anti-virus, anti-virus and anti-tumor, etc., and has therapeutic effects on many diseases, such as ulcers, neurasthenia, skin aging, thrombosis, atherosclerosis and immune deficiency, etc. (U.S. Patent No. 20030092144).

[0005] Geranylgeraniol is a biosynthetic precursor for a variety of biochemically important products, such as terpenoids, carotene, steroids, cholesterol, and paclitaxel (Taxol  )Wait.

[0006] Geranylgeraniol is also an important organic synthesis intermediate of various drugs, such as coenzyme Q n (I), vitamin K (II and III) series compounds, ...

Claims

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