Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Black-white formulation for treating insomnia

A preparation, black and white technology, applied in the field of black and white preparations, to achieve the effect of preventing cardiovascular and cerebrovascular diseases, low toxicity, and reducing the risk of cardiovascular and cerebrovascular diseases

Inactive Publication Date: 2007-02-14
陈彦方
View PDF1 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, so far, there is no sleeping drug that fully meets the above conditions

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

Embodiment approach 1

[0024] 1. Dissolve 3mg of melatonin in dilute ethanol and mix it with 500mg of xylooligosaccharide to granulate;

[0025] 2. Dissolve 100mg of 5-hydroxytryptophan in dilute ethanol and mix it with 500mg of xylooligosaccharide to granulate;

[0026] 3. Dissolve 25mg of diphenhydramine in dilute ethanol and mix it with 500mg of xylooligosaccharide to granulate;

[0027] 4. Mix the obtained melatonin granules, 5-hydroxytryptophan granules and diphenhydramine granules with magnesium stearate, dry them, mix them with a lubricant, and fill them into capsules.

Embodiment approach 2

[0029] 1. Combine 5-hydroxytryptophan 200mg, melatonin 6mg, and vitamin B 6 6 mg was dissolved in dilute ethanol and then granulated and dried.

[0030] 2. mix 75mg diphenhydramine hydrochloride, 100mg crystalline cellulose, 700mg lactose, 20mg cross carmellose sodium, 50mg light silicon dioxide, add the ethanol solution of 240mg10% hydroxypropyl cellulose, stir, prepare Grain and dry.

[0031] 3. Mix the granules obtained in 1 and 2 evenly. Tablet.

Embodiment approach 3

[0033] Weigh 50g 5-hydroxytryptophan, 2g melatonin, 6g and vitamin B 6 , 10g diphenhydramine hydrochloride (the above components are used to prepare 1000 bags of granules), add 1420g sucrose, 100g starch and 100g dextrin, make wetting agent with 75% ethanol, granulate with 16 mesh sieves, drying temperature at 60°C for 2 hours, after drying, sieve the granules with a 14-mesh sieve in a swing-type granulator, pack into bags and divide into granules to obtain granules.

[0034] Preparation of white preparation:

[0035] Implementation plan one:

[0036]1. Mix 50mg of caffeine and microcrystalline cellulose with equal increment method, then mix with pregelatinized starch evenly, add 5% PVPK30 solution to make soft material, sieve and granulate to dry or directly use one-step granulation mechanism grain.

[0037] 2. Pass 50 mg of aspirin, ethyl cellulose microcrystalline cellulose, and starch through an 80-mesh sieve and mix well. Using 1.5% ethyl cellulose ethanol solution as...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention provides a black and a white preparation for treating insomnia, wherein the formula of the black preparation comprises 5-hydroxytryptophane, melatonin, diphenhydramine, and its acid addition salts, the formula of the white preparation comprises aspirin and caffeine. The black preparation can be used for treating insomnia and the white preparation can be used for eliminating hangover.

Description

technical field [0001] The invention relates to a black and white preparation, in particular to a black and white preparation for treating insomnia, adjusting sleep rhythm and reducing jet lag. Background technique [0002] The most basic definition of insomnia is sleep disturbance and refers to the frequent inability to get normal sleep. Researchers believe that insomnia is insufficient sleep, or sleep is not deep, not familiar, generally presents three characteristics of initial insomnia, intermittent insomnia and terminal insomnia. Occasional insomnia doesn't matter much, and only those who can't sleep for a long time are considered to have insomnia. The incidence of insomnia is very high. According to foreign data surveys, the incidence of insomnia in the American population is 32% to 35%, and that in Japan is 20%. There are also a large number of insomnia patients in China, especially the number of middle-aged and elderly people who suffer from insomnia. Foreign stat...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/405A61K31/4045A61K31/522A61K31/616A61P25/20
Inventor 陈彦方汪光亮
Owner 陈彦方
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com