Bactericidal/disinfectant peracetic composition

A technology of peracetic acid and phosphate, used in the field of decontamination, can solve the problems of skin itching, weakened unpleasant odor, unpleasant odor, and itchy skin.

Inactive Publication Date: 2001-12-19
更家株式会社
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] High concentrations of peracetic acid can cause skin itching and a bad smell, but when diluted into a practical solution (generally containing 0.2-0.35% peracetic acid), the resulting skin itching and bad smell will be reduced. relatively weakened

Method used

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  • Bactericidal/disinfectant peracetic composition
  • Bactericidal/disinfectant peracetic composition
  • Bactericidal/disinfectant peracetic composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0074] A 0.33% aqueous solution of peracetic acid (pH 4.0) containing 1% sodium thiosulfate and 0.05% of one of the nonionic surfactants listed in Table 1 was prepared. The aqueous peracetic acid solution was placed in a glass beaker and stored at room temperature (25°C) for 2 weeks. Samples of the aqueous peracetic acid solutions were withdrawn periodically during storage, and the concentrations of peracetic acid in the sample solutions were measured according to the method described by Sully, B.D. and Williams, P.L., Analytical 1962;87:653-657.

[0075] Table 1 nonionic surface active additive 1.Newdet PE85 (polyoxyethylene / polyoxypropylene block polymer, Sanyo Chemical Industries Co., Ltd.) 2.Ionet T-60C (polyoxyethylene sorbitol fatty acid, Sanyo Chemical Industries Co, Ltd.) 3 Emulmin 70 (polyoxyethylene alkyl ether, Sanyo Chemical Industries Co, Ltd.) 4. Nonipole 100 (polyoxyethylene nonylphenyl ether, Sanyo Chemical Industries Co., Ltd.) 5 . Noygen ET-190 (polyethylene...

Embodiment 2

[0080] Dipotassium hydrogen phosphate was added to the 0.3% peracetic acid solution to make the final concentration 0.296% (pH3.5). The prepared solution was divided into 6 parts, and each part was added with surfactant, reactant and mixture thereof (① to ⑥ in Table 2) to form a test solution. The test solutions were stored at room temperature (25°C). The concentration of peracetic acid in the test solution and the effect of the test solution on bacterial spores were measured every day.

[0081] Table 2 Additives

[0082] ① No additives (comparison 1)

[0083] ② Newdet PE85 0.05%

[0084] ③Newpole PE64 0.05%

[0085] ④Nonipole 100 0.05%

[0086] ⑤Newdet PE85 0.05%+EDTA2Na 0.025%

[0087] +EDTA4Na 0.025%

[0088] ⑥EDTA2Na 0.025%+EDTA4Na 0.025% (comparison 2)

[0089] Figures 2 and 3 show the results of measurements of the concentration of peracetic acid in each sample.

[0090] As shown in Figures 2 and 3, after 10 days of storage at room temperatur...

Embodiment 3

[0097] The following two formulations were prepared:

[0098] first reactant

[0099] Peracetic acid 6%

[0100] Hydrogen Peroxide 8%

[0101] Acetic acid 32%

[0102] Phosphate type stabilizer 0.2%

[0103] water balance

[0104] Second reactant

[0105] Dipotassium Phosphate 6%

[0106] Newdet PE85 (Sanyo Chemical Industries Co., Ltd.) 1%

[0107] EDTA2Na 0.5%

[0108] EDTA4Na 0.5%

[0109] water balance

[0110] The first and second reagents were mixed in equal amounts and diluted 10 times by volume to make a test solution. The solution contained about 0.33% peracetic acid.

[0111] The test solution was used to sterilize and disinfect endoscopes using a newly developed automatic endoscope cleaner for this purpose.

[0112] The biopsy forceps (Olympus GIF type XQ240; Olympus Optical Industries, Co., Ltd.) of the flexible endoscope used in the upper gastrointestinal tract were supplied by an automatic endoscope cleaner (Olympus EW-30; Olympus Optical Industries, ...

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Abstract

A bactericidal preparation mainly composed of peracetic acid, containing peracetic acid, at least one phosphate and at least one nonionic surfactant. The bactericidal preparation can be diluted into a working solution containing peracetic acid, and the concentration of peracetic acid can destroy bacterial spores and acid-resistant bacteria, while maintaining the concentration of the working solution for at least 7 days.

Description

field of invention [0001] The present invention relates to the field of decontamination. More specifically, the present invention relates to a bactericide / disinfectant for use in medical instruments such as medical instruments and endoscopes, gauze and other articles. Background of the invention [0002] Now, preparations with glutaraldehyde as the active ingredient are commonly used for sterilization and disinfection of medical devices. However, it has been recently reported that glutaraldehyde preparations have a weak bactericidal effect on acid-resistant bacteria. Furthermore, allergic reactions to glutaraldehyde preparations frequently occur in Western countries. Therefore, glutaraldehyde-free formulations have been gradually developed and marketed. [0003] High concentrations of peracetic acid can cause skin itching and a bad smell, but when diluted into a practical solution (generally containing 0.2-0.35% peracetic acid), the resulting skin itching and bad smell wi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A01N37/16
CPCA01N37/16A01N59/26A01N59/00A01N37/02A01N25/30A01N2300/00A61L2202/24
Inventor 安原亨吉田惠美子
Owner 更家株式会社
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