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Hemostatic agent and its preparing method

A technology of medicament and quartz powder, which is applied in the direction of medical formula, blood disease, drug combination, etc., can solve the problems of long time required for hemostatic effect, high price, high cost, etc., to achieve full utilization of resources, simple production process, The effect of low production cost

Inactive Publication Date: 2007-07-25
汕头市金丰医疗器械科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Hemostatic powder, Yunnan Baiyao and other topical hemostatic drugs that were often used in the past have been gradually abandoned because they cannot quickly achieve the hemostatic effect
In recent years, snake venom thrombin-like hemostatic drugs produced from snake venom extracts that have been used or developed at home and abroad are mainly used for pre-operation hemostasis by intravenous injection, intramuscular injection or subcutaneous injection, etc., but its hemostatic efficacy The time required is long, and the price is expensive and not easy to be generally accepted by users
The hemostatic drug in a new type of hemostatic bandage developed by the United States in recent years is made of shrimp shells, and its hemostatic speed is relatively fast, but it needs more than 20 series of chemical reactions to complete its production process, and the process is complicated. The cost is high and the price is relatively expensive
A recent hemostatic product in the United States, that is, a spray preparation made of mineral particles by Z-Medica, the hemostatic effect has been greatly improved, and the price is relatively low, but its price is still unaffordable for ordinary users

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Take the viscera and brains of livestock and poultry (such as pigs, cattle brains, liver, lungs, large intestine lining, spleen, etc.) semi-solid crude product, then the obtained crude product is extracted with a solvent (the temperature is 45~60 ℃), and then vacuum-dried to obtain polyphosphoric acid ester, the solvent used in the above soaking and extraction process is all acetone, diethyl ether and A mixture of petroleum ether prepared in a weight ratio of 1:1:1;

[0020] The mixture of phosphate soil and quartz powder (wherein the weight ratio of phosphate soil and quartz powder is 1:1) is crushed and sieved to make the particle size reach 150 mesh, and then extracted with pure water to remove water-soluble impurities and ion, then carry out vacuum drying and high pressure treatment (pressure is 10 atmospheres), obtain the negatively charged phosphate soil and quartz powder mixture of purification;

[0021] The polyphosphate ester that above-mentioned steps obtains...

Embodiment 2

[0024] Take the viscera and brains of livestock and poultry (such as the brains of pigs and cattle, liver, lungs, large intestine lining, spleen, etc.) The semi-solid crude product is then extracted with a solvent (the temperature can be 60-70°C), and then vacuum-dried to obtain polyphosphoric acid ester. The solvents used in the above soaking and extraction processes are all acetone, diethyl ether A mixture prepared with petroleum ether in a weight ratio of 0.8:1.1:1.1;

[0025] The mixture of phosphate soil and quartz powder (wherein the weight ratio of phosphate soil and quartz powder is 1.05:0.95) is crushed and sieved to make the particle size reach 150 mesh, and then extracted with pure water to remove water-soluble impurities and ion, then carry out vacuum drying and high pressure treatment (pressure is 20 atmospheres), obtain the negatively charged phosphate soil and quartz powder mixture of purification;

[0026] The polyphosphate ester that above-mentioned steps obt...

Embodiment 3

[0029] Take the viscera and brains of livestock and poultry (such as pigs, cattle brains, liver, lungs, large intestine lining, spleen, etc.) The semi-solid crude product is then extracted with a solvent (the temperature can be 70-85° C.), and then vacuum-dried to obtain polyphosphoric acid ester. The solvents used in the above soaking and extraction processes are all acetone, diethyl ether A mixture prepared with petroleum ether in a weight ratio of 1.2:0.9:0.9;

[0030] The negatively charged phosphate soil and quartz powder mixture (wherein the weight ratio of phosphate soil and quartz powder is 0.95:1.05) is crushed and sieved to make the particle size reach 150 mesh, and then extracted with pure water to remove the Water-soluble impurities and ions, then carry out vacuum drying and high-pressure treatment (pressure is 15 atmospheres), obtain the negatively charged phosphorus soil and quartz powder mixture of purification;

[0031] The polyphosphate ester that above-menti...

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PUM

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Abstract

The hemostatic preparation consists of polyphosphate ester, mixture of negatively charged kaolin and quartz powder and chitosan in the weight ratio of 0.8-1.2 to 0.9-1.1 to 0.9-1.1. The preparation process includes the following steps: preparing polyphosphate ester with internal organ and / or encephalon of farm animal; mixing, purifying and negatively charging kaolin and quartz powder; mixing polyphosphate ester, mixture of negatively charged kaolin and quartz powder and chitosan and vacuum drying. The hemostatic preparation has fast hemostatic speed, high hemostatic effect and no side effect, and may be prepared into various forms. The hemostatic preparation is suitable for various hemorrhagic diseases and trauma hemorrhage.

Description

technical field [0001] The invention relates to a hemostatic agent and a preparation method thereof. Background technique [0002] At present, hemostatic agents are mainly used for the treatment of various bleeding diseases, as well as for the hemostasis of surgical operations and traumatic bleeding and the prevention of bleeding before operations. The methods of oral administration, intramuscular injection, intravenous injection and external application are usually adopted when they are used. It takes a long time. Hemostatic powder, Yunnan Baiyao and other topical hemostatic drugs that were often used in the past have been gradually abandoned because they cannot quickly achieve the hemostatic effect. In recent years, snake venom thrombin-like hemostatic drugs produced from snake venom extracts have been used or developed at home and abroad. They are mainly used for pre-operation hemostasis by intravenous injection, intramuscular injection or subcutaneous injection, etc., b...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K33/42A61K31/80A61K33/00A61K31/722A61P7/04
Inventor 黄广雄王富华
Owner 汕头市金丰医疗器械科技有限公司