New monomeric insulin and its medicinal composition and prepn process

A technology of insulin and monomers, applied in the fields of medicine and pharmacy, can solve problems such as chemical side reactions, difficulty in large-scale production, and complicated process flow
CN1468864AInactive Publication Date: 2004-01-21SHANGHAI C A S SHENGLONGDA BIOTECH GRP
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
SHANGHAI C A S SHENGLONGDA BIOTECH GRP
Publication Date
2004-01-21
Estimated Expiration
Not applicable · inactive patent

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Abstract

The present invention provides new insulin strand B, monomeric insulin containing strand B, medicinal composition containing the monomeric insulin and their preparation process and use. The insulin analog B27K-DTrI sample of high purity is obtained via enzymatic semi-synthesis process and is proved to have the property of monomeric insulin and overall insulin activity 80 % of that of normal insulin. The monomeric insulin precursor is secreted and expressed in yeast expressing system and enzyme cut to obtain B27K-DTrI, and the enzymatic peptide converting step is omitted to raise the final yield and suit for industrial production.
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Description

technical field

[0001] The present invention relates to the fields of medicine and pharmacy. More specifically, the present invention relates to a novel insulin B chain, a monomeric insulin containing the B chain, a pharmaceutical composition containing the monomeric insulin, and its preparation method and use. Background technique

[0002] The incidence of diabetes is increasing year by year, and it can cause death from cardiovascular disease. It is one of the major diseases threatening human health today. Hyperglycemia is the cause of various diabetic complications, and strictly controlling the blood sugar concentration within the normal range 24 hours a day is the most critical factor to prevent and delay the complications of late diabetes.

[0003] Insulin has been an irreplaceable drug since it was used to treat diabetes in the 1920s. However, the secretion of insulin in a normal human body is regulated by the blood sugar concentration. Generally, the blood insulin co...

Claims

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