Water soluble spherical holing agent and its preparing process and use

A porogen and water-soluble technology, applied in the field of materials, can solve the problems of small channels, inability to prepare large-volume three-dimensional scaffolds, and difficult control of channel shape and size

Inactive Publication Date: 2004-07-14
上海组织工程研究与开发中心
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  • Summary
  • Abstract
  • Description
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Problems solved by technology

[0014] Particle leaching method combined with phase separation technology [Chantar E. Hawley, Molly S. Shoichet, John E. Davis, biodegradable polymer scaffold, CN1285757A] preparation method, Three-dimensional scaffolds with good permeability can be obtained, but the channels between the pores are small and difficult to control, which is not conducive to cell migration
The salt dissolution method [Murphy, W L, Dennis R G, Kileny J L, and Mooney D J, Salt Fusion: an approach to improve pore interconnectivity within tissue engineering scaffolds, Tissue Engineering, 2002, 8 (1): 43-52] can improve the inter-pore interconnectivity. Connectivity, however, the channel shape and size of the pores connected are not easy to cont...

Method used

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  • Water soluble spherical holing agent and its preparing process and use
  • Water soluble spherical holing agent and its preparing process and use
  • Water soluble spherical holing agent and its preparing process and use

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preparation example Construction

[0053] The invention provides a method for preparing a spherical water-soluble porogen, which comprises the steps of:

[0054] (a) Mix the porogen raw material with the dispersant to form a mixture

[0055] The selection criteria that can be used for the porogen raw material of the present invention are: the porogen raw material has crystalline properties, good water solubility, suitable hygroscopicity, suitable melting point (preferably lower than 260 degrees), non-toxic or low toxicity , a wide range of sources, low cost, insoluble in organic solvents, relatively stable chemical properties. Suitable porogen raw materials are compounds selected from the group consisting of sodium chlorate, succinimide, urea, sodium thiocyanate, potassium thiocyanate, or mixtures thereof. The melting point of the porogen raw material is T1.

[0056] The dispersant that can be used in the present invention is an organic solvent whose flash point T2 is 50-100° C. higher than the melting point ...

Embodiment 1

[0088] Preparation of spherical porogen (porogen raw material is sodium chlorate)

[0089] 1. In a 500ml beaker, add 400ml H-201 methyl silicone oil (flash point greater than 300°C, specific gravity 0.96-0.975 / 25°C, viscosity 500cp / 25°C. Purchased from the Affiliated Factory of Hangzhou Normal University) and 10-20g chlorine Sodium acid, place the beaker on a temperature-controlled heating device, and install a mechanical stirring device. Adjust the stirring speed to 200 rpm. Under stirring, slowly heat the methyl silicone oil to 260-270°C [not higher than 280°C], so that the sodium chlorate becomes liquid microspheres; then, keep the stirring speed constant, Slowly cool down to 246°C at a rate of 2°C / min. At this moment, the liquid sodium chlorate microspheres are converted into solid state microspheres, and the stirring is stopped. Sodium chlorate) deposition, the methyl silicone oil in the upper layer is poured off, and the spherical porogen can be obtained by suction filt...

Embodiment 2

[0095] Preparation of spherical porogen (porogen raw material is succinimide)

[0096] The steps of Example 1 were repeated, except that 10-20 grams of succinimide was used to replace sodium chlorate, and the heating temperature was 130-140° C.

[0097] After drying the spherical porogen, sieve the sample with a sieve with a pore size of 600 μm, 450 μm, 355 μm, 220 μm and 100 μm to obtain a diameter of 600μm spherical porogen, sealed and stored in a desiccator.

[0098] As a result, spherical porogens with a diameter of 100-600 microns were also obtained.

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Abstract

The present invention provides a kind of water soluble spherical pore-creating agent of size 100-1000 micron and comprising sodium chlorate, succinimide, urea, sodium thiocyanate, potassium thiocyanate, or their mixture. The water soluble spherical pore-creating agent may be used in preparing large 3D biodegradable rack with high porosity, spherical and communicating pores capable of being artificially controlled in pore size and communicating channel size.

Description

technical field [0001] The invention relates to the field of materials, more specifically to a water-soluble porogen that can be used to prepare a three-dimensional scaffold for tissue engineering, its preparation method and application. Background technique [0002] The loss or dysfunction of tissues and organs is one of the main hazards faced by human health, and it is also one of the most important causes of human disease and death. The number of cases of tissue, organ loss or dysfunction caused by trauma and disease in my country ranks first in the world, which has become a heavy burden for the country and patients. The emerging tissue engineering technology provides a brand-new means of repairing and manufacturing organs, and brings a new way of treatment for patients with organ defects and necrosis. [0003] Tissue engineering involves three aspects: seed cells, biodegradable materials and tissue construction. Among them, biodegradable materials are one of the import...

Claims

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Application Information

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IPC IPC(8): A61F2/00A61L27/00A61L31/06
Inventor 曹谊林陈际达崔磊刘伟
Owner 上海组织工程研究与开发中心
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