Water soluble spherical holing agent and its preparing process and use

Abstract

The present invention provides a kind of water soluble spherical pore-creating agent of size 100-1000 micron and comprising sodium chlorate, succinimide, urea, sodium thiocyanate, potassium thiocyanate, or their mixture. The water soluble spherical pore-creating agent may be used in preparing large 3D biodegradable rack with high porosity, spherical and communicating pores capable of being artificially controlled in pore size and communicating channel size.

Description

technical field [0001] The invention relates to the field of materials, more specifically to a water-soluble porogen that can be used to prepare a three-dimensional scaffold for tissue engineering, its preparation method and application. Background technique [0002] The loss or dysfunction of tissues and organs is one of the main hazards faced by human health, and it is also one of the most important causes of human disease and death. The number of cases of tissue, organ loss or dysfunction caused by trauma and disease in my country ranks first in the world, which has become a heavy burden for the country and patients. The emerging tissue engineering technology provides a brand-new means of repairing and manufacturing organs, and brings a new way of treatment for patients with organ defects and necrosis. [0003] Tissue engineering involves three aspects: seed cells, biodegradable materials and tissue construction. Among them, biodegradable materials are one of the import...

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Problems solved by technology

[0014] Particle leaching method combined with phase separation technology [Chantar E. Hawley, Molly S. Shoichet, John E. Davis, biodegradable polymer scaffold, CN1285757A] preparation method, Three-dimensional scaffolds with good permeability can be obtained, but the channels between the pores are small and difficult to control, which is not conducive to cell migration

The salt dissolution method [Murphy, W L, Dennis R G, Kileny J L, and Mooney D J, Salt Fusion: an approach to improve pore interconnectivity within tissue engineering scaffolds, Tissue Engineering, 2002, 8 (1): 43-52] can improve the inter-pore interconnectivity. Connectivity, however, the channel shape and size of the pores connected are not easy to control, and the pores are cube-shaped; the particle leaching method after bonding spherical paraffin particles by thermal fusion [Ma P X, Choi J W, Biodegradable polymer scaffolds with well- defined interconnected spherical porenetwork, Tissue Engineering, 2001, 7(1): 23-33], a three-dimensional scaffold with high porosity and interconnected spherical pores can be obtained, but paraffin particles are water-insoluble porogens, which limit The range of solvent selection for polymers. In the experiment, pyridine, which has an unacceptable smell, was used as the solvent for polymers. On the other hand, due to the problem of temperature gradient in hot-melt bonding, this method cannot prepare large-volume three-dimensional scaffolds.

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