Porous calcium carbonate-hydroxyapatite gradient material and preparing method thereof

A technology of hydroxyapatite and porous calcium carbonate, which is applied in the field of medical materials, can solve problems such as non-degradability, and achieve the effects of simple production process, reduced production cost, and strict controllable conditions

Inactive Publication Date: 2004-09-15
上海惠谷生物技术开发有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although the conversion product has good compatibility and porosity, it cannot be degraded and will remain as a foreign body for a long time after implantation

Method used

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  • Porous calcium carbonate-hydroxyapatite gradient material and preparing method thereof
  • Porous calcium carbonate-hydroxyapatite gradient material and preparing method thereof
  • Porous calcium carbonate-hydroxyapatite gradient material and preparing method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] The mechanism of water heat exchange reaction is (taking (NH4)2HPO4 as phosphate as an example):

[0036]

[0037] 10×100 6×136 2×18 1028 6×96 4×62

[0038] It can be seen that 1000 grams of CaCO3 is converted into Ca10(PO4)6(OH)2, (NH4)2HPO4816 grams are needed, therefore, by adjusting the reaction system (NH 4 ) 2 HPO 4 Gradient materials with different conversion ratios can be obtained.

[0039] Take by weighing (NH4) 2HPO4 4.08 grams (0.03mol) (sample 1), 8.16 grams (0.06mol) (sample 2), 16.32 grams (0.12mol) (sample 3), 32.64 grams (0.24mol) (test Sample 4), dissolved in triple-distilled water, reacted with 100 g (1 mol) of porous CaCO3 in a closed container at 280°C for 12 hours to obtain different samples, also weighed (NH4)2HPO4 and porous CaCO3, and reacted at 140°C After 96 hours, samples 5, 6, 7, and 8 were obtained. The samples were taken out, washed in boiling water, and dried for later use.

Embodiment 2

[0041] The coral calcium carbonate used in the experiment was ground into a fine powder, and mixed with the commercially available analytical pure hydroxyapatite powder at intervals of 10% (the ratios of hydroxyapatite and calcium carbonate were 100:0; 90:10; 80:20 ; 70:30; 60:40; 50:50; 40:60; 30:70; 20:80; 10:90; 0:100), X-ray diffraction analysis was carried out to obtain the X-ray diffraction peaks of the two Intensity ratio, draw the curve of hydroxyapatite content and peak intensity ratio ( figure 1 ). The sample obtained in Example 1 is ground into fine powder, dried, and X-ray diffraction analysis is carried out to determine its composition ( figure 2 ), and compared with the curve of hydroxyapatite content and peak intensity ratio, the content of hydroxyapatite in the sample was obtained (Table 1).

[0042] Table 1 is the curve of hydroxyapatite-calcium carbonate peak intensity ratio and hydroxyapatite content.

[0043] The abscissa is the hydroxyapatite content (...

Embodiment 3

[0062] The sample 2 sample obtained in embodiment 1, get section and carry out X-ray energy spectrum analysis, the result shows, sample surface ( image 3 Middle point A) The atomic ratio of calcium to phosphorus is 1.88 ( Figure 4 ),central( image 3 Middle B point) no phosphorus atom, still CaCO3 ( Figure 5 ). It shows that the hydroxyapatite formed after transformation covers the inner calcium carbonate in a thin coat. At the same time, the obtained product still maintains a good three-dimensional pore structure ( image 3 ).

[0063] image 3 This is the cross section of Sample 2 obtained in Example 1.

[0064] Figure 4 is the line spectrum analysis result of point A.

[0065] Figure 5 is the line spectrum analysis result of point B.

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Abstract

The invention discloses a multihole calcium carbonate-hydroxyapatite gradient material as well as its preparing method. It converts the calcium carbonate into the base of hydrothermal reaction of the hydroxyapatite and changes the content of the calcium carbonate and phosphate to obtain biomaterials of different conversion ratios. Its surface has a hydroxyapatite thin coat layer and its center has the calcium carbonate- hydroxyapatite with the content gradient 4.5%-33.8%. It has good biocompatibility, high-degree and multihole, and has controllable biodegrading speed.

Description

Technical field: [0001] The invention belongs to the technical field of medical materials. Specifically relates to a porous calcium carbonate-hydroxyapatite gradient material and a preparation method. Background technique: [0002] Artificial bone graft materials are divided into two categories: organic materials and inorganic materials. Natural organic materials such as collagen and chitin have good biocompatibility, but they degrade quickly in vivo, have poor mechanical strength, and are not easy to shape, so they are currently mainly used as carriers of cells and growth factors. Synthetic organic materials mainly include polyglycolide, polylactide and their copolymers. The degradation rate in vivo can be controlled. Such high-molecular-weight materials have good mechanical strength, but they easily cause non-specific inflammatory reactions when they remain in the body and affect bone tissue. organization formation. Inorganic materials mainly include hydroxyapatite, tri...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/12
Inventor 孙家驹
Owner 上海惠谷生物技术开发有限公司
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