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A kind of multi-layer degradable pipe material, bracket and preparation method thereof

A technology for pipes and degrading polymers, applied in the field of medical devices, can solve the problems of insufficient radial strength of composite pipes, reducing effective components of drugs, and being prone to brittle fracture. Compatibility effect

Active Publication Date: 2019-02-15
SHANGHAI MICROPORT MEDICAL (GROUP) CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The disadvantage of this method is that the radial strength of the injection-molded composite pipe is insufficient, and it is easy to produce silver streaks when directly used in the preparation of the stent or the stent is prone to brittle fracture during the expansion process.
And the drug may reduce the active ingredient of the drug by melting and mixing in the polymer instead of coating on the surface of the stent

Method used

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  • A kind of multi-layer degradable pipe material, bracket and preparation method thereof
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  • A kind of multi-layer degradable pipe material, bracket and preparation method thereof

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preparation example Construction

[0042] The preparation method of the multilayer degradable pipe provided by the present invention includes the following steps:

[0043] a) Select the polymer materials of the inner layer and the outer layer with a crystallinity of less than 20%, and obtain the original pipe through multi-layer extrusion; preferably, the polymer materials of the inner layer and the outer layer are placed in Multi-layer extrusion is carried out in the barrel of the layer extruder.

[0044] b) Put the original pipe into a tubular mold with good thermal conductivity and not easy to deform, the inner diameter of the mold is equal to the required outer diameter of the pipe after expansion;

[0045] c) Heating the original pipe and tubular mold to a temperature T, the range of the temperature T is: higher than the highest glass transition temperature Tg of the polymer (ie the highest glass transition temperature of all layers of polymer), lower than the polymer The lowest melting temperature Tm of the mat...

Embodiment 1

[0050] (1) In this embodiment, the original extruded pipe has two layers inside and outside; figure 1 with figure 2 As shown, the polymer material of the outer layer 3 is L-polylactic acid, and the polymer material of the inner layer 1 is a polylactic acid-caprolactone copolymer. The ratio of the polylactic acid-caprolactone copolymer is polylactic acid / caprolactone= 90 / 10.

[0051] (2) Place the inner and outer polymer materials in the barrel of the multilayer extruder respectively, and obtain the original multilayer extruded pipe with an outer diameter of 1.45 mm and a wall thickness of 0.515 mm through extrusion. Among them, the outer polymer wall thickness is 0.192mm, and the inner polymer wall thickness is 0.323mm.

[0052] (3) Inflate radially and axially stretch the pipe to an outer diameter of 3.0mm and an inner diameter of 2.7mm. Processing temperature is 80℃;

[0053] (4) Using femtosecond laser cutting technology to prepare a double-layer biodegradable scaffold. After ...

Embodiment 2

[0058] (1) In this embodiment, the original extruded pipe has two layers inside and outside, such as figure 1 with figure 2 As shown, the polymer material of the outer layer 3 is L-polylactic acid, and the polymer material of the inner layer 1 is a copolymer of polylactic acid and caprolactone. The ratio of the copolymer of polylactic acid and caprolactone is polylactic acid / caprolactone=70 / 30.

[0059] (2) Place the inner and outer layer polymer materials in the barrel of the multilayer extruder, and obtain the original multilayer extruded pipe with an outer diameter of 1.45 mm and a wall thickness of 0.515 mm through extrusion. Among them, the outer polymer wall thickness is 0.192mm, and the inner polymer wall thickness is 0.323mm.

[0060] (3) Inflate radially and axially stretch the pipe to an outer diameter of 3.0mm and an inner diameter of 2.7mm. Processing temperature is 80℃;

[0061] (4) Using femtosecond laser cutting technology to prepare a double-layer biodegradable sc...

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Abstract

The invention discloses a multilayer degradable tube and stent and a preparation method thereof. The tube is tubular and at least comprises two layers, wherein all the different layers of the tube are made of biodegradable polymer material. The tube at least comprises an inner layer and an outer layer, the molecular weight of a material of the outer layer is higher that of a material of the inner layer. The degradable stent is made by cutting the multilayer degradable tube, the degrading rate of the degradable tube decreases sequentially from the inner layer to the outer layer, the outer layer is made of the material high in mechanical strength and long in degrading time, and the material can support a blood vessel for a long enough time; the inner layer is good in biocompatibility, the material short in degrading time can improve the compatibility of the stent with blood, the inner layer degrades first so that mass degrading debris produced during overall disintegrating of the stent is reduced, and tubular area at a vascular position will increase gradually with degrading of the inner layer.

Description

Technical field [0001] The present invention relates to the field of medical devices, in particular to a multilayer degradable pipe, a stent, and a preparation method and application thereof. Background technique [0002] As we all know, coronary heart disease is the most common heart disease in China, and it is the main cause of death of heart disease patients. Coronary heart disease is a disease caused by the deposition of cholesterol or other lipids on the inner walls of coronary arteries to form "plaques", resulting in narrowing or blockage of blood vessels. Over time, this layer of silt-up "plaque" will slow down the blood flow to the heart, which can induce chest pain. If the blood vessels are completely blocked and oxygen cannot enter the heart, the patient will suffer a heart attack / myocardial infarction or damage to the heart tissue due to lack of oxygen in the heart. [0003] Stent implantation is to implant a stent into a blocked blood vessel under the guidance of a ca...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L31/12A61L31/16A61L31/14
Inventor 高晨光陈树国孟娟
Owner SHANGHAI MICROPORT MEDICAL (GROUP) CO LTD
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