Method for preparing slow release micro pill of aspirin

A technology of aspirin and pellets, which is applied in the field of slow-release pellet preparations of aspirin prepared by using the mother-nucleus-free amplification technology, which can solve the problems of high cost and high market price of pellet preparations, and achieve low production costs and reduced capsule content The effect of reducing the weight of the product and reducing the volume of the capsule

Inactive Publication Date: 2004-12-15
TIANJIN PACIFIC PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, most of the existing micropill preparations are made by using blank micropills through enlarging coating, and the price of blank micropills is relatively high, generally 30-60 yuan / kg, which makes the cost high, resulting in a high market price of micropill preparations, giving a The large number of patients brings economic pressure

Method used

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  • Method for preparing slow release micro pill of aspirin
  • Method for preparing slow release micro pill of aspirin

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Embodiment 1: Preparation of drug-containing pellets

[0033] Preparation of prescription: (per 1000 capsules)

[0034] Aspirin 75g

[0035] Starch 15g

[0036] Sucrose 75g

[0037] Dextrin 30g

[0038] Povidone K30 8g

[0039] 95% ethanol 150g

[0040] Preparation:

[0041] Crush aspirin and sucrose through a 100-mesh sieve, and mix the starch and dextrin evenly in proportion after passing through a 100-mesh sieve. Put half of the mixed powder into the cutting-jet granulator, start the equipment, and adjust the air intake to 700M 3 / h, the air inlet temperature is 45°C, the air inlet slit is about 0.5cm, the turntable speed is 45rpm, then start the spray gun, adjust the air injection pressure to 0.2Mpa, and the peristaltic pump speed is 15rpm, spray the adhesive, until the diameter of the pellet When it reaches 400-600um, stop spraying liquid, take it out after drying for about 10 minutes, sieve the 400-600um pellets and put them into the...

Embodiment 2

[0042] Embodiment 2: the preparation of drug-containing pellets

[0043] Preparation of prescription: (per 1000 capsules)

[0044] Aspirin 75g

[0045] Starch 10g

[0046] Lactose 55g

[0047] Microcrystalline Cellulose 50g

[0048] Hypromellose 5g

[0049]95% ethanol 150g

[0050] Preparation:

[0051] Crush aspirin through a 100-mesh sieve, starch, lactose, and microcrystalline cellulose through a 100-mesh sieve and mix evenly in proportion, put half of the mixed powder into the cutting spray granulator, start the equipment, and adjust the air intake to 700M 3 / h, the air inlet temperature is 45°C, the air inlet slit is about 0.5cm, the turntable speed is 45rpm, then start the spray gun, adjust the air injection pressure to 0.2Mpa, and the peristaltic pump speed is 15rpm, spray the adhesive, until the diameter of the pellet When it reaches 400-600um, stop spraying liquid, take it out after drying for about 10 minutes, sieve the 400-600um pellets an...

Embodiment 3

[0052] Embodiment 3: the coating of drug-containing pellet

[0053] To prepare a prescription:

[0054] Contains pills 1000g

[0055] Acrylic resin No. II 50g

[0056] Tween ~ 80 15g

[0057] 95% ethanol 1000g

[0058] Talc 20g

[0059] Preparation:

[0060] Soak and dissolve the prescribed amount of acrylic resin No. II and Tween-80 in 95% ethanol, let it stand for 12 hours, and stir evenly for later use. Put the pills into the coating machine, adjust the speed to 50rpm, and the air intake to 800M 3 / h, the air inlet temperature is 50°C, the atomization pressure is 0.2Mpa, and then the spray gun is started, the peristaltic pump speed is 15rpm, and the coating solution is sprayed. Sprinkle a small amount of talc in time according to the static electricity generation during coating to remove static electricity and ensure the coating effect. Continue to dry for 15 minutes after the coating is finished. Take out the pellets and place them in a drying ...

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Abstract

The slow releasing micro pill of aspirin has the recipe comprising aspirin, cane sugar or lactose, starch, dextrin or avicel, povidone or hydroxypropyl methyl cellulose, ethanol, Tween-80, acrylic resin and talcum powder. The preparation process includes processing the main material and supplementary material, mixing in certain proportion, pelletizing to form medicine containing micro pill and coating. The present invention has low production cost.

Description

technical field [0001] The invention relates to a sustained and controlled release pellet preparation of aspirin, in particular to a method for preparing the slow and controlled release pellet preparation of aspirin by using a mother-nucleus-free amplification technology. Background technique [0002] Aspirin is a drug that has been used for nearly a hundred years. Its main pharmacological effect is antipyretic and anti-inflammatory in large doses, and it has a clear anticoagulant effect at 50-150 mg, so it is used as a commonly used drug to prevent various types of thrombosis. But the side effects of aspirin, mainly gastrointestinal irritation, are also significant. It is especially noticeable with high doses or long-term use. There have been many medical reports about gastric ulcer and gastric bleeding caused by heavy use of aspirin. Aspirin enteric-coated tablets have been produced and sold to reduce gastric irritation, but the tablets are greatly affected by the gastri...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/16A61K31/616A61P29/00
Inventor 宋德成
Owner TIANJIN PACIFIC PHARMA
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