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Cefadroxil oral disintegrant tablet, and its prepn. method

A cefadroxil oral cavity and cefadroxil technology are applied in the field of cefadroxil oral disintegrating tablets and their preparation fields, and can solve the problems of not being able to fully meet the medication needs of all patients, difficulty in swallowing patients taking the medicine, and children being unable to take it by themselves, and the like. The effect of shortening the dissolution time, increasing the absorption point, and good compliance

Active Publication Date: 2005-05-25
CSPC ZHONGQI PHARM TECH (SHIJIAZHUANG) CO LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The dosage forms of cefadroxil currently in clinical use include tablets, capsules, and granules. These oral dosage forms need to be taken with water, and it will be difficult for patients who have difficulty swallowing or inconvenient water intake; although granules are specially designed for children. However, since most children cannot drink it by themselves, and it is inconvenient to take granules in schools or kindergartens, these dosage forms cannot fully meet the medication needs of all patients

Method used

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  • Cefadroxil oral disintegrant tablet, and its prepn. method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0046] Embodiment 1: Cefadroxil orally disintegrating tablet

[0047] Component Weight Weight %

[0048] Cefadroxil 132g (equivalent to cefadroxil 44% (equivalent to cefadroxil

[0049] Ampicillin Anhydrate 125g) Ampicillin Anhydrate 41.7%)

[0050] Mannitol 93g 31%

[0051] Aspartame 1.5g 0.5%

[0052] Menthol 1g 0.33%

[0053] Sweet Orange Powder Flavor 6g 4.55%

[0054] 5% povidone 95% ethanol appropriate amount

[0055] the solution

[0056]Low substituted hydroxypropyl cellulose 12g 4%

[0057] Microcrystalline Cellulose 48g 16%

[0058] Tartaric acid 1.5g 0.5%

[0059] Sodium bicarbonate 1.5g 0.5%

[0060] Magnesium Stearate 3g 1%

[0061] Total weight 300g

[0062] A total of 1000 pieces were made

[0063] Concrete preparation method is as follows:

[0064] Weigh cefadroxil, mannitol, aspartame, menthol, sweet orange powder essence and part of low-substituted hydroxypropyl cellulose that have passed through a 100-mesh sieve, mix well and a...

Embodiment 2

[0065] Embodiment 2: Cefadroxil orally disintegrating tablet

[0066] Component Weight Weight %

[0067] Cefadroxil 132g (equivalent to cefadroxil 26.4% (equivalent to cefadroxil

[0068] Amoxycillin Anhydrous 125g) Amoxycillin Anhydrous 25%)

[0069] Erythrose 180g 60%

[0070] Aspartame 2.5g 0.5%

[0071] Menthol 1g 0.2%

[0072] Sweet Orange Powder Flavor 12g 2.4%

[0073] 50% ethanol appropriate amount

[0074] Mannitol Powder 60g 12%

[0075] Low-substituted hydroxypropyl cellulose 20g 4%

[0076] Microcrystalline Cellulose 80g 16%

[0077] Citric acid 5g 1%

[0078] Sodium bicarbonate 2.5g 0.5%

[0079] Magnesium Stearate 5g 1%

[0080] Total weight 500g

[0081] A total of 1000 pieces were made

[0082] Concrete preparation method is as follows:

[0083] Weigh cefadroxil, erythrose, aspartame, menthol, sweet orange powder essence and part of low-substituted hydroxypropyl cellulose that have passed through a 100-mesh sieve, mix well, add ...

Embodiment 3

[0084] Embodiment 3: Cefadroxil orally disintegrating tablet

[0085] Component Weight Weight %

[0086] Cefadroxil 264g (equivalent to cefadroxil 44% (equivalent to cefadroxil

[0087] Ampicillin Anhydrate 250g) Ampicillin Anhydrate 41.7%)

[0088] Erythrose 184g 30.7%

[0089] Aspartame 3g 0.5%

[0090] Menthol 2g 0.33%

[0091] Sweet Orange Powder Flavor 12g 2%

[0092] 50% ethanol appropriate amount

[0093] Crospovidone 40g 6.7%

[0094] Microcrystalline Cellulose 80g 13.3%

[0095] Citric acid 6g 1%

[0096] Sodium bicarbonate 3g 0.5%

[0097] Magnesium Stearate 6g 1%

[0098] Total weight 600g

[0099] A total of 1000 pieces were made

[0100] Concrete preparation method is as follows:

[0101] Weigh cefadroxil, erythrose, aspartame, menthol, sweet orange powder essence and part of cross-linked povidone that passed through a 100-mesh sieve, mix well, add an appropriate amount of 50% ethanol to granulate, and mix the rest Crospovidone, citric ...

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Abstract

An oral disintegrating tablet of dracefal contains dracefal and the medicinal excipient (water-soluble filler, disintegrant, lubricant, wetting agent, or adhesive). Its preparing process is also disclosed. Its advantages are high disintegrating speed, quickly taking its effect, less residue and low by-effect.

Description

technical field [0001] The invention relates to a cefadroxil orally disintegrating tablet and a preparation method thereof. technical background [0002] Cefadroxil is a broad-spectrum antibiotic with high antibacterial activity against Staphylococcus aureus, various streptococci and anaerobic cocci. It also has a strong antibacterial effect on certain Enterobacteriaceae. Its bactericidal mechanism is similar to other β-lactam antibiotics, and it is achieved by inhibiting the formation of bacterial cell walls. The drug has the advantages of broad antibacterial spectrum, strong bactericidal effect, long half-life and the like. It is clinically used for respiratory tract, urinary tract, skin, and soft tissue infections caused by sensitive bacteria. Its adverse reactions are few and mild, mainly gastrointestinal reactions. [0003] The structural formula of cefadroxil is as follows: [0004] [0005] The dosage forms of cefadroxil currently in clini...

Claims

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Application Information

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IPC IPC(8): A61K9/20A61K31/545A61P31/04
Inventor 刘立云陈素锐陈玉洁闫随朝申东民陈晓鹏
Owner CSPC ZHONGQI PHARM TECH (SHIJIAZHUANG) CO LTD
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