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Breviscapine oral rapidly disintegrating formulation and its preparing process

A technology for breviscapine and oral fast disintegrating tablets, which is applied in the directions of pill delivery, pharmaceutical formulations, and medical preparations containing active ingredients, etc., can solve the problems of poor disintegration performance, shorten the drug dissolution time, etc. Good appearance, good absorption effect

Inactive Publication Date: 2005-07-06
YUNNAN INST OF MATERIA MEDICA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

It overcomes the disadvantages of poor disintegration performance of existing general tablets, making it convenient for patients with dysphagia and patients in an anhydrous or inconvenient drinking environment to take medicine. The dissolution time of the drug is improved, which helps the drug to take effect quickly

Method used

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  • Breviscapine oral rapidly disintegrating formulation and its preparing process

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0024] Example 1: Formula Breviscapine 20.10g

[0025] Microcrystalline Cellulose 45g

[0026] Low-substituted hydroxypropyl cellulose 5g

[0027] Micronized silica gel 2g

[0028] Magnesium Stearate 1g

[0029] Protein sugar 2g

[0030] Starch 25g

[0031] Preparation method: Weigh the main drug and other auxiliary materials except magnesium stearate and 1 / 2 low-substituted hydroxypropyl cellulose according to the formula ratio, mix them thoroughly, pass through a 100-mesh sieve, and add an appropriate amount of distilled water to prepare a soft material , pass through a 20-mesh sieve to granulate, dry at 40-50°C, and sieve the granules and fine powder between 20-80 mesh, add the reserved low-substituted hydroxypropyl cellulose and magnesium stearate, mix well and press piece.

example 2

[0032] Example 2: Formula Breviscapine 20.10g

[0033] Microcrystalline Cellulose 60g

[0034] Low-substituted hydroxypropyl cellulose 6g

[0035] Micronized silica gel 2g

[0036] Magnesium stearate 0.5g

[0037] Protein sugar 3g

[0038] Starch 8.5g

[0039] Preparation method: Weigh the main drug and other auxiliary materials according to the formula ratio, pass through a 100-mesh sieve, fully mix, and directly compress the whole powder into tablets.

example 3

[0040] Example 3: Formula Breviscapine 23.0g

[0041] Microcrystalline Cellulose 54g

[0042] Low-substituted hydroxypropyl cellulose 5g

[0043] Micronized silica gel 1g

[0044] Magnesium stearate 0.5g

[0045] Protein sugar 2g

[0046] Starch 14.5g

[0047]Preparation method: Weigh the main drug and other auxiliary materials except magnesium stearate and 1 / 2 low-substituted hydroxypropyl cellulose according to the formula ratio, mix thoroughly, pass through a 100-mesh sieve, and add an appropriate amount of 60% ethanol to prepare Soft materials, granulated through a 20-mesh sieve, dried at 40-50°C, and granules and fine powders between 20-mesh and 80-mesh were sieved, added with low-substituted hydroxypropyl cellulose and magnesium stearate, and mixed well After compression.

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Abstract

The invention relates to an orally disintegrating tablet containing active component extract of Breviscapine, a medicinal herb, and the process for preparation, wherein the tablet comprises extract of reactive constituents and medicinal adjuvant, including 20.01-25.50 wt% of Breviscapine flavones active constituents, 45-60% of crystalline cellulose, 5-7% of low substituted methylcellulose propylene glycol ether, 1-3% of miropowdered silica gel, 0.25-1% of magnesium stearate, 2-3% of egg white sweet, and balancing starch.

Description

technical field [0001] The invention relates to an orally rapidly disintegrating tablet made from scutellarin, an active component extract of natural medicinal plants, and a preparation method thereof. Background technique [0002] The active ingredient, breviscapusvaut, is extracted and refined from Yunnan specialty medicinal material Erigeron breviscapusvaut, Hand Mazz. Pharmacological experiments and clinical use have proved that the drug has the functions of dilating microvessels, improving microcirculation, reducing blood viscosity, anti-platelet aggregation, promoting fibrinolysis, anti-thrombolysis, increasing tissue perfusion, scavenging free radicals, lowering blood sugar, lowering It is clinically used to treat cerebral thrombosis, paralysis caused by cerebral hemorrhage and sequelae of traumatic cranial trauma. Coronary heart disease, angina pectoris, myocardial infarction, hyperlipidemia, retinal vein occlusion and microcirculation disturbance. The preparations...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K31/7048A61P3/06A61P9/10
Inventor 周莹赵洪伟孙媛马定仕彭红琼段丽萍闫晓丹
Owner YUNNAN INST OF MATERIA MEDICA
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