Methylamino avermectin benzoate water dispersant granule and preparation method thereof

A technology of emamectin and benzoate, which is applied in the field of pesticide preparation and can solve the problem of single dosage form

Inactive Publication Date: 2005-09-21
武汉绿世纪生物工程有限责任公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, at present, the commercial dosage form of emamectin emamectin salt is relatively single, mainly emulsifiable oil and microemulsion, and water-dispersible granules have not been reported and no patent application has been seen yet.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] Example 1 Preparation of 1% emamectin emamectin saline dispersible granules

[0017] The solvent is made by mixing methanol and ethyl acetate in equal proportions, the emulsifier is made by mixing Span-80 and calcium dodecylbenzenesulfonate in equal proportions, and the coating agent is made of bleached tea dry powder, lauryl Sodium benzenesulfonate and dextrin (3:3:4) were thoroughly mixed and then pulverized to more than 400 mesh with a jet mill.

[0018] First add 1.0 kg of emamectin emamectin salt (press B 1 100% calculation of the components) is dissolved in 5 kg of solvent, and then 12 kg of emulsifier is added to the solution, fully mixed to form a mixed solution of emamectin benzoate. Weigh 79 kilograms of carrier (white granulated sugar crystals), and load it into a rotary granulator (Beijing Telijie Machinery Technology Co., Ltd. TLJ-125 type). Start the motor to rotate the drum at a speed of 80rpm. Spray the prepared emamectin emamectin salt mixed solution...

Embodiment 2

[0019] Example 2 Preparation of 1.5% emamectin emamectin saline dispersible granules

[0020] The solvent is a single solvent, namely 95% ethanol. The emulsifier is prepared by mixing Tween-60 and sodium dodecylbenzenesulfonate in a ratio of 2:3. The coating agent is composed of sodium dodecyl sulfonate, mica powder and soluble starch (4:3:3), and then pulverized with a jet mill to more than 400 mesh for later use.

[0021] Accurately weigh 1.5 kg of emamectin benzoate (according to B 1 The component content is calculated by 100 percent), and dissolved with 6 kilograms of 95% ethanol to obtain an ethanol solution of emamectin emamectin. Add 12 kilograms of emulsifiers in the solution again, fully mix. Then weigh the carrier (urea and KCl, 1:1, w / w) to make up to 90 kg of solids, and put it into a self-made stirring granulator. Start stirring and adjust the stirring speed to 120 rpm. Slowly add the drug mantle material into the granulator through the pipeline, spread it on...

Embodiment 3

[0022] Example 3 Preparation of 2% emamectin emamectin saline dispersible granules

[0023] The solvent is prepared by mixing absolute ethanol, isopropanol and dimethyl sulfoxide (6:3:1). The emulsifier is made by thoroughly mixing Tween 80 and sodium dodecylsuccinate benzene sulfonate (2:3). The coating agent is prepared by mixing saponin powder, dextrin, sodium dodecylbenzenesulfonate and white carbon black (1:2:4:3), and pulverizing to more than 400 mesh with a jet mill.

[0024] Accurately weigh 2 kg of emamectin emamectin salt (press B 1 The component content is calculated by 100 percent), and it is set aside. Then take by weighing 8 kilograms of solvents and 15 kilograms of emulsifiers. After the two are fully mixed, 2 kilograms of emamectin benzoate are added therein, and the stirring is continued for more than 1 hour until the emamectin benzoate is completely dissolved and becomes a drug substance. Weigh the carrier (NaNO 3 crystallization) about 72 kg, the carrier...

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PUM

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Abstract

The invention discloses a water dispersing pelletized granule of methylamino avermectin benzoate and its preparing method. The water dispersing palletized granule is the crystal of saccharide compounds such as sucrose and lactose, the preparing method is:adopt crystal of the water-soluble compound like the inorganic salt such as KCl, NaCl, NH4Cl, NaSO4, (NH4)2SO4, NaNO3, KNO3, KH2PO4, K2HPO4 and NH4H2PO4 or the chemical fertilizer such as aquacare to be the carrier of the granula, then cover the surface with miscible liquids of formiate, emulsifier and high penetrating agent, finally, lagging cover the granula when it is wet with powdered lagging cover agent.

Description

technical field [0001] The invention belongs to the field of pesticide preparation, in particular to a water-dispersible granule of emamectin benzoate and a preparation method thereof. Background technique [0002] Abamectin benzoate (hereinafter referred to as "amamectin salt") is the abamectin B1 a A high-efficiency insecticidal compound obtained after structural modification. Its insecticidal activity, especially against Noctuidae pests such as cotton bollworm, beet armyworm and Spodoptera litura than abamectin B1 a Greatly improved, while the toxicity to mammals is greatly reduced. Therefore, emamectin benzoate has become an important pesticide variety for preventing and controlling agricultural pests. But at present, emamectin emamectin salt commercial dosage form is relatively single, mainly contains emulsifiable concentrate and microemulsion, and water dispersible granule has not been reported yet and has not seen to have patent application. [0003] The conventio...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A01N25/14A01N43/90
Inventor 谢九皋林开春张国安
Owner 武汉绿世纪生物工程有限责任公司
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