Medication combination of Xuefu Zhuyu in application for preparing hypolipidemic

A technology of Xuefu Zhuyu and composition, which is applied in the application field of Xuefu Zhuyu pharmaceutical composition in the preparation of blood lipid-lowering drugs, can solve the problems of blood lipid lowering not mentioned, and achieve remarkable curative effect, safe and reliable effect, good The effect of prevention and treatment

Inactive Publication Date: 2006-02-01
TIANJIN HONGRENTANG PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0014] It has not been mentioned in the above prior art that the Xuefu Zhuyu pharmaceutical composition has the indications of lowering blood fat and treating hyperlipidemia, blood vessels and traumatic headaches

Method used

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Examples

Experimental program
Comparison scheme
Effect test

experiment example 1

[0022] Experimental Example 1: Effect of Xuefu Zhuyu Capsules on Hemorheology

[0023] Test purposes:

[0024] To observe the effects of repeated intragastric administration of Xuefu Zhuyu Capsules on the whole blood viscosity of rats with hyperviscosity caused by polymer dextran and the specific viscosity of blood plasma in rats with blood stasis caused by adrenaline hydrochloride.

[0025] Test material drugs:

[0026] Xuefu Zhuyu Capsule—provided by Tianjin Hongrentang Pharmaceutical Co., Ltd., each capsule contains 0.4g of powder. Lot number 010301. The following test doses are calculated according to the amount of powder. 1% CMC was used to make a suspension with a suitable concentration for intragastric administration to rats.

[0027] Compound Danshen Tablets—produced by Shijiazhuang Hualong Pharmaceutical Co., Ltd. Lot number 201001. 1% CMC was used to make a suspension with a suitable concentration for intragastric administration to rats....

experiment example 2

[0045] Experimental Example 2: Pharmacodynamics Test Report of Xuefu Zhuyu Capsules

[0046] Abstract OBJECTIVE: To observe the effects of Xuefu Zhuyu Capsules on lipid-lowering, microcirculation, hemorheology and other aspects of experimental animals, so as to confirm the clinical lipid-lowering effect of Xuefu Zhuyu Capsules. The results showed that Xuefu Zhuyu Capsules (4, 2, 1g / kg) could reduce serum cholesterol (TC) and serum triglyceride (TG) to hyperlipidemia rats by oral administration for 20 days. ) and elevated high-density lipoprotein cholesterol (HDL-C) levels. Improve mouse auricle circulation, there is a tendency to reduce blood viscosity in rats, but Xuefu Zhuyu Capsules (4, 2, 1g / kg) have no significant effect on blood lipid levels in normal mice after oral gavage for 14 days.

[0047]1. Experimental materials

[0048] 1.1 Drugs and reagents:

[0049] Xuefu Zhuyu Capsule: Provided by Tianjin Hongrentang Pharmaceutical Co., Ltd. Batch number: 040220

[0050...

experiment example 3

[0090] Experimental Example 3: Clinical Observation Report of Honghua Brand Xuefu Zhuyu Capsules

[0091] Abstract: The purpose of the experiment: To observe the curative effect and safety of Honghua Xuefu Zhuyu Capsules in treating blood stasis, and to evaluate the curative effect of Honghua Xuefu Zhuyu Capsules in treating angina pectoris of coronary heart disease. Experimental method: outpatients were randomly divided into treatment group and control group, followed up and comparative observation. Test results: Honghua Xuefu Zhuyu Capsules have statistically significant improvement in blood stasis syndromes such as headache, insomnia, chest tightness, menstrual disorders, and tongue purpura. Compared with the control group, the improvement of symptoms, tongue quality, electrocardiogram, blood rheology, platelets and other laboratory indicators in patients with coronary heart disease and angina pectoris has a significant statistical difference. No adverse reactions were see...

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PUM

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Abstract

A Chinese medicine for decreasing fat in blood and treating hyperlipemia and the vascular and traumatic headache is prepared from 11 Chinese-medicinal materials including peach kernel, Chinese angelica root, Chuan-xiong rhizome, safflower, etc.

Description

technical field [0001] The invention relates to a new medical application of a Chinese patent medicine, in particular to the application of a Xuefu Zhuyu pharmaceutical composition in the preparation of blood lipid-lowering medicine. Background technique [0002] Xuefu Zhuyu Capsule is a classic Chinese patent medicine, the Ministry of Health standard WS 3 -B-0928-91 [0003] Record the prescription: [0004] 200g peach kernel (stir-fried), 150g angelica, 100g aurantium husk (stir-fried bran), 75g Chuanxiong, 50g Bupleurum, 150g safflower, 150g Achyranthes bidentata, 100g red peony root, 150g rehmannia root, 75g bellflower, 50g licorice [0005] Functions and indications: promoting blood circulation and removing blood stasis, promoting qi and relieving pain. Used for blood stasis internal resistance, chest pain or headache, internal heat and depression, insomnia and dreaminess, palpitations, irritability and anger. [0006] In addition, the application date is 2001.1.5, ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/00A61P3/06A61P25/04A61P29/02
Inventor 朱晓晶李永仓李凤阁马洪波温艳娜喆
Owner TIANJIN HONGRENTANG PHARM CO LTD
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