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Super paramagnetic ferric oxide composite nanometre particle preparation method

A technology of superparamagnetic iron oxide and composite nanoparticles, which is applied in the direction of iron oxide, nanostructure manufacturing, iron oxide/iron hydroxide, etc., can solve problems such as difficulty, reduce yield, simplify process steps, and promote production Nuclear and outgrowth effects

Inactive Publication Date: 2006-02-22
HUAZHONG UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although chain molecules such as oleic acid are introduced after the synthesis of SPION by chemical coprecipitation, SPION dispersed in the oil phase can also be obtained; but if an ionic surface stabilizer is introduced, it is difficult to obtain completely dispersed and stable SPION in the water phase. not easy

Method used

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  • Super paramagnetic ferric oxide composite nanometre particle preparation method
  • Super paramagnetic ferric oxide composite nanometre particle preparation method
  • Super paramagnetic ferric oxide composite nanometre particle preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] 1.1. Add 4.64 g of FeCl 3 ·6H 2 O (17mmol) and 1.70 g FeCl 2 4H 2 O (8.5mmol) dissolved in 250ml deoxygenated deionized water (18.2MΩ·cm -1 ), put it into a 500ml three-necked round-bottom reaction flask equipped with a mechanical stirring rod, and be protected by a nitrogen atmosphere; the concentration of 100ml of ammonia water 100ml of 1MOL / L and the deionized water preparation of deoxidation is the sodium citrate of 1MOL / L After mixing 19ml of the solution, drop it into the rapidly stirred iron and ferrous salt solution at a rate of 4ml / min; the color of the solution gradually turns brown, and finally dark black; after the addition of the mixed solution is completed, the stirring reaction continues for more than 30 minutes; During the whole reaction process, the temperature is always controlled at about 50°C; the obtained superparamagnetic iron oxide nanoparticle ferrofluid is quickly moved into a container and sealed for storage;

[0043] 1.2. Add 200ml of sodi...

Embodiment 2

[0045] 2.1. Add 3.712 grams of FeCl 3 ·6H 2 O (13.6 mmol) and 1.368 g FeCl 2 4H 2 After O (6.8mmol) was dissolved in 50ml deoxygenated deionized water, put it into a 100ml three-necked round-bottomed reaction bottle equipped with a mechanical stirring bar, and be protected by a nitrogen atmosphere; prepare 67ml of ammonia water with a concentration of 3MOL / L and deoxidized deionized water After mixing 5.1ml of sodium citrate solution with a concentration of 3MOL / L, drop it into the rapidly stirred iron and ferrous salt solution at a rate of 2ml / min; the color of the solution gradually turns brown, and finally dark black; the mixture is added dropwise After completion, the stirring reaction continued for more than 30 minutes; during the entire reaction process, the temperature was always controlled at about 80°C; the obtained superparamagnetic iron oxide nanoparticle ferrofluid was quickly moved into a container and sealed for storage;

[0046] 2.2. Add 100ml concentration t...

Embodiment 3

[0048] 3.1. Add 2.784 g of FeCl 3 ·6H 2 O (10.2 mmol) and 1.02 g FeCl 2 4H 2 After O (5.1mmol) was dissolved in 200ml deoxidized deionized water, put it into a 500ml three-necked round-bottom reaction flask equipped with a mechanical stirring bar, and be protected by a nitrogen atmosphere; After mixing 20ml of sodium citrate solution with a concentration of 0.5MOL / L prepared by nanopure water, drop it into the rapidly stirred iron and ferrous salt solution at a rate of 5ml / min; the color of the solution gradually becomes dark black; the mixed droplet After the addition is complete, the stirring reaction continues for more than 30 minutes; during the entire reaction process, the temperature is always controlled at about 40°C; the obtained superparamagnetic iron oxide nanoparticle magnetic fluid is quickly moved into a container and sealed for storage;

[0049] 3.2. Add 250ml of sodium citrate solution with a concentration of 4.85mMOL / L to a 500ml three-necked round-bottomed ...

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Abstract

The invention discloses a preparation method for composite nano particcle of superparamagnetic ferric oxide. Wherein, adding ammonia and sodium citrate synchronously and speed controlled to make ions of Fe3+ and Fe2+ coprecipitate and form Fe3O4 nano particle with water-phase dispersion surface adsorbed by citric acid radical that can be substituted by multi chemical functional group on basic condition as crystal seed for sodium citrate-goden chloric acid reduction reaction and form SPION nano particle.

Description

technical field [0001] The invention belongs to the technical field of nano magnetic materials, and relates to a preparation method of magnetic composite nanoparticles dispersed in water phase. Background technique [0002] Nanoscale materials have become a hot research field in materials science because of their unique physical and chemical properties different from their bulk materials. The core content of nanoscience and technology is to study the peculiar physical properties and mechanism of nanomaterials, and to make use of their characteristics. In recent years, the research progress of nanomaterials, especially the application of nanoparticles in the field of biomedicine, has made nanobiotechnology in the magnetic separation of proteins and cells, quantum dots instead of fluorescein, nuclear magnetic resonance contrast agents, and DNA medical diagnosis. exciting results. [0003] Since its appearance in 1960, superparamagnetic iron oxide nanoparticles (SPION) and it...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C01G49/06B82B3/00
Inventor 姚凯伦卢强华刘祖黎宁琴习东罗小平
Owner HUAZHONG UNIV OF SCI & TECH
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