Dispersible tablet of erigeron breviscapus effective component extracts and preparation method thereof

Abstract

The invention relates to a medicinal preparation whose main medicinal constituent is the extract of active fleabane ingredient, and its preparing process, wherein the dispersible tablet comprises 10-80 wt% of the extract micro powder of active fleabane ingredient and balancing medicinal auxiliary materials, the preparation can be used for activating blood circulation, removing stasis, improving heart and brain blood circulation, and increasing anoxybiotic tolerant capacity, thus is mainly suitable for treating cardiovascular and cerebrovascular diseases and their after-effects, eyeground retina venous clogging, vasculitis skin diseases and rheumatosis.

Description

technical field

[0001] The invention relates to a pharmaceutical preparation which takes active ingredient extract of breviscapine as the main medicinal ingredient and a preparation method thereof. technical background

[0002] Erigeron breviseapus (Vant.) Hand.-Mazz is the dry whole herb of Erigeron breviseapus (Vant.) Hand.-Mazz. The folks in Yunnan call it Erigeron breviscapus, Erigeron breviscapus, and Asarum elegans, which have been included in the national standard. The original breviscapine extract products, Yimaikang and breviscapine capsules, are all based on the determination of the total flavonoids of breviscapine. The total flavonoids of breviscapine are isolated and extracted from breviscapine, mainly flavonoids, and the main components are scutellarin (scutellarin), scutellarin, apigenin, luteolin, baicalein, etc. The products extracted from Erigeron breviscapus are: the implementation standard is WS 3 -B-3823-98 Erigeron injection, the implementation standa...

Examples

Embodiment 1

[0046] Erigeron breviscapus extract micropowder 100g

[0047] Mannitol 90g

[0048] Starch 130g

[0049] Microcrystalline Cellulose 189g

[0050] Sodium Alginate 23g

[0051] Phospholipids 1g

[0052] Polyethylene glycol (2000~6000) 2g

[0053] Micronized silica gel 2g

[0054] Take Erigeron breviscapus that meets the drug standard, grind it into coarse powder, pass through a 10-20 mesh sieve, extract 3 times with 6, 5, and 5 times the amount of 40% ethanol, combine the extracts, and clarify with clarifiers such as chitin. Filtrate, concentrate at <60°C, recover ethanol, concentrate to a thick paste, dry, and perform ultra-fine processing such as airflow milling and ball milling to obtain micropowder of breviscapine extract with a particle size of less than 150 μm.

[0055] Preparation method of dispersible tablets:

[0056] 1. The processing of raw materials The fineness requirements of auxiliary materials: over 80 mesh, the particle size of the extract after ultra-fin...

Embodiment 2

[0070] Erigeron extract micronized powder 50g

[0071] Sorbitol 98g

[0072] 100g pregelatinized starch

[0073] Microcrystalline Cellulose 180g

[0074] Colloidal Magnesium Aluminum Silicate 23g

[0075] Perilla oil 1g

[0076] Magnesium Lauryl Sulfate 1g

[0077] Micronized silica gel 2g

[0078] Take Erigeron breviscapus that meets the drug standards, grind it into coarse powder, pass through a 10-20 mesh sieve, extract 3 times with 70% of 6, 5, and 5 times the amount respectively, combine the extracts, clarify with clarifiers such as chitin, and filter , concentrate and recover ethanol until the alcohol content is less than 20%, first filter once with medium-speed filter paper, then filter once with hollow fiber column, and filter once with 0.4 μm membrane, concentrate the filtrate until the solid content is below 10%, control Spray drying is carried out under the liquid inlet volume, and the inlet temperature is controlled at 75°C to 95°C, and the outlet temperature...

Embodiment 3

[0080] Erigeron Extract Micronized Powder 180g

[0081] Xylitol 77g

[0082] Lactose 150g

[0083] Microcrystalline Cellulose 171g

[0084] Cross-linked polyvinylpyrrolidone 28g

[0085] Alpha-linolenic acid 1g

[0086] Make the finished product of dispersible tablet by embodiment 1.

technical field

[0001] The invention relates to a pharmaceutical preparation which takes active ingredient extract of breviscapine as the main medicinal ingredient and a preparation method thereof. technical background

[0002] Erigeron breviseapus (Vant.) Hand.-Mazz is the dry whole herb of Erigeron breviseapus (Vant.) Hand.-Mazz. The folks in Yunnan call it Erigeron breviscapus, Erigeron breviscapus, and Asarum elegans, which have been included in the national standard. The original breviscapine extract products, Yimaikang and breviscapine capsules, are all based on the determination of the total flavonoids of breviscapine. The total flavonoids of breviscapine are isolated and extracted from breviscapine, mainly flavonoids, and the main components are scutellarin (scutellarin), scutellarin, apigenin, luteolin, baicalein, etc. The products extracted from Erigeron breviscapus are: the implementation standard is WS 3 -B-3823-98 Erigeron injection, the implementation standa...

Examples

Embodiment 1

[0046] Erigeron breviscapus extract micropowder 100g

[0047] Mannitol 90g

[0048] Starch 130g

[0049] Microcrystalline Cellulose 189g

[0050] Sodium Alginate 23g

[0051] Phospholipids 1g

[0052] Polyethylene glycol (2000~6000) 2g

[0053] Micronized silica gel 2g

[0054] Take Erigeron breviscapus that meets the drug standard, grind it into coarse powder, pass through a 10-20 mesh sieve, extract 3 times with 6, 5, and 5 times the amount of 40% ethanol, combine the extracts, and clarify with clarifiers such as chitin. Filtrate, concentrate at <60°C, recover ethanol, concentrate to a thick paste, dry, and perform ultra-fine processing such as airflow milling and ball milling to obtain micropowder of breviscapine extract with a particle size of less than 150 μm.

[0055] Preparation method of dispersible tablets:

[0056] 1. The processing of raw materials The fineness requirements of auxiliary materials: over 80 mesh, the particle size of the extract after ultra-fin...

Embodiment 2

[0070] Erigeron extract micronized powder 50g

[0071] Sorbitol 98g

[0072] 100g pregelatinized starch

[0073] Microcrystalline Cellulose 180g

[0074] Colloidal Magnesium Aluminum Silicate 23g

[0075] Perilla oil 1g

[0076] Magnesium Lauryl Sulfate 1g

[0077] Micronized silica gel 2g

[0078] Take Erigeron breviscapus that meets the drug standards, grind it into coarse powder, pass through a 10-20 mesh sieve, extract 3 times with 70% of 6, 5, and 5 times the amount respectively, combine the extracts, clarify with clarifiers such as chitin, and filter , concentrate and recover ethanol until the alcohol content is less than 20%, first filter once with medium-speed filter paper, then filter once with hollow fiber column, and filter once with 0.4 μm membrane, concentrate the filtrate until the solid content is below 10%, control Spray drying is carried out under the liquid inlet volume, and the inlet temperature is controlled at 75°C to 95°C, and the outlet temperature...

Embodiment 3

[0080] Erigeron Extract Micronized Powder 180g

[0081] Xylitol 77g

[0082] Lactose 150g

[0083] Microcrystalline Cellulose 171g

[0084] Cross-linked polyvinylpyrrolidone 28g

[0085] Alpha-linolenic acid 1g

[0086] Make the finished product of dispersible tablet by embodiment 1.