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Soft capsule of'Yu Feng Ning Xin' and preparation thereof

A technology of soft capsule and soft capsule shell, which can be used in capsule delivery, testing of pharmaceutical preparations, cardiovascular system diseases, etc.

Inactive Publication Date: 2006-05-10
北京创立科创医药技术开发有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Since the kudzu root extract in Yufeng Ningxin Tablets is obtained by reflux extraction of 80% to 90% alcohol, the product is easy to absorb moisture after being made into tablets, which will affect the curative effect of the product; during the production process of tablets, hardness, weight, etc. often appear. Differences, unqualified disintegration time limit and other quality problems, backward technology and quality standards, difficult disintegration, poor absorption, low bioavailability
Moreover, it is difficult to swallow the tablet, and the patient's compliance is poor, resulting in the inability to take the medicine according to the doctor's advice, resulting in ineffective treatment

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0063] Contents Prescription

[0064] Pueraria 1250g made into 1000 grains Soybean oil as diluent, beeswax as suspending agent, polysorbate 80 as wetting agent

[0065] Capsule Prescription

[0066] Gelatin 416g Purified water 416g Glycerin 145.6g Polyethylene glycol 40020.8g

[0067] Brown iron oxide 0.832g Ethylparaben 0.832g Propylparaben 0.832g

[0068] Made into 1000g

[0069] method

[0070] Take 187.5g of kudzu root, crush it into fine powder, take another 1062.5g of kudzu root, heat and reflux three times with 80%-90% ethanol, the first time is 4 hours, the amount of alcohol added is 8 times the amount, the second and third time are 3 hours each, add The amount of alcohol is 6 times the amount, filter, combine the filtrates, recover ethanol, concentrate under reduced pressure to a clear paste with a relative density of 1.40 (50°C). Take the clear paste, mix it with Pueraria root fine powder, dry, crush, pass through a...

Embodiment 2

[0072] Contents Prescription:

[0073] Pueraria 1666g made into 1000 grains of soybean oil as diluent, beeswax as suspending agent, polysorbate 80 as wetting agent

[0074] Capsule Prescription

[0075] Gelatin 416g Purified water 416g Glycerin 145.6g Polyethylene glycol 40020.8g

[0076] Brown iron oxide 0.832g Ethylparaben 0.832g Propylparaben 0.832g

[0077] Made into 1000g

[0078] method

[0079] Take 250g of kudzu root, crush it into fine powder, and take the rest of kudzu root, heat and reflux three times with 80% to 90% ethanol. 6 times the amount, filtered, combined filtrates, recovered ethanol, and concentrated under reduced pressure to a clear paste with a relative density of 1.40 (50°C). Take the clear cream, mix it with Pueraria root fine powder, dry, pulverize, pass through a 100-mesh sieve to get fine powder, and set aside; take another 3g of beeswax, put it in 146g of soybean oil, heat to dissolve, let it coo...

Embodiment 3

[0081] Contents Prescription:

[0082] Pueraria 937g made into 1000 grains of soybean oil as diluent, beeswax as suspending agent, polysorbate 80 as wetting agent

[0083] Capsule Prescription

[0084] Gelatin 416g Purified water 416g Glycerin 145.6g Polyethylene glycol 40020.8g

[0085] Brown iron oxide 0.832g Ethylparaben 0.832g Propylparaben 0.832g

[0086] Made into 1000g

[0087] method

[0088] Take 140g of kudzu root, crush it into fine powder, and take the rest of kudzu root, and heat and reflux three times with 80% to 90% ethanol. 6 times the amount, filtered, combined filtrates, recovered ethanol, and concentrated under reduced pressure to a clear paste with a relative density of 1.40 (50°C). Take the clear paste, mix it with kudzu root fine powder, dry, crush, pass through a 100-mesh sieve to get fine powder, and set aside; take another 11g of beeswax, put it in 500g of soybean oil, heat to dissolve, let it cool, add polysor...

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Abstract

The invention relates to a soft capsule and method of preparation, wherein the soft capsule is prepared from 1250g of kudzuvine root and capsule shell, the capsule shell comprises gelatin 416g, pure water 416g, glycerin 145.6g, polyethylene glycol 400 20.8g, ferric oxide 0.832g, ethylparaben 0.832g, and propylparaben 0.832g.

Description

Technical field: [0001] The invention relates to a traditional Chinese medicine preparation, in particular to the reformation of the dosage form of Yufeng Ningxin Tablets, which is transformed into Yufeng Ningxin Soft Capsules. The soft capsules are made of 1250g of kudzu root and a soft capsule shell. The softgel capsule shell consists of: [0002] Gelatin 416g Purified water 416g Glycerin 145.6g Polyethylene glycol 400 20.8g [0003] Brown iron oxide 0.832g, ethylparaben 0.832g, propylparaben 0.832g. Background technique: [0004] Yufeng Ningxin Soft Capsule is reformed from Yufeng Ningxin Tablet. Yufeng Ningxin Tablet is a variety recorded in the 2000 edition of "Chinese Pharmacopoeia". Its function is to relieve spasm and relieve pain, and enhance cerebral and coronary blood flow. For high blood pressure dizziness, headache, neck pain, coronary heart disease, angina pectoris, nervous headache, early sudden deafness and other diseases. [0005] Since the kudzu root ex...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/488A61K9/48A61P9/10A61P9/12A61P25/04G01N30/02G01N33/15
Inventor 和芳胡玉霞何渭清
Owner 北京创立科创医药技术开发有限公司
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